Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23984 | Target Info | |||
| Target Name | Bromodomain-containing protein 7 (BRD7) | ||||
| Synonyms | Protein CELTIX-1; CELTIX1; BP75; 75 kDa bromodomain protein | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BRD7 | ||||
| Biochemical Class | Bromodomain | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Bromosporine | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of human BRD7 bound to bromosporine | PDB:6V1H | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMA
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| Ligand Name: BI 7273 | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of human BRD7 bound to BI7273 | PDB:6V1E | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMADL
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| Ligand Name: TG003 | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of human BRD7 bound to TG003 | PDB:6V0Q | ||||
| Method | X-ray diffraction | Resolution | 1.69 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMADL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EAE or .EAE2 or .EAE3 or :3EAE;style chemicals stick;color identity;select .A:155 or .A:156 or .A:160 or .A:164 or .A:165 or .A:168 or .A:207 or .A:210 or .A:211 or .A:217; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: I-BRD9 | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of human BRD7 bound to I-BRD9 | PDB:6V17 | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMADL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H1B or .H1B2 or .H1B3 or :3H1B;style chemicals stick;color identity;select .A:154 or .A:155 or .A:156 or .A:160 or .A:164 or .A:165 or .A:166 or .A:168 or .A:207 or .A:210 or .A:211 or .A:212 or .A:215 or .A:217; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of human BRD7 bound to TP472 | PDB:6V16 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMAD
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QMG or .QMG2 or .QMG3 or :3QMG;style chemicals stick;color identity;select .A:154 or .A:155 or .A:156 or .A:158 or .A:159 or .A:160 or .A:164 or .A:165 or .A:168 or .A:207 or .A:210 or .A:211 or .A:216 or .A:217; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One | Ligand Info | |||||
| Structure Description | Crystal structure of the BRD7 bromodomain in complex with BI-9564 | PDB:5MQ1 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [2] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5U6 or .5U62 or .5U63 or :35U6;style chemicals stick;color identity;select .A:153 or .A:154 or .A:155 or .A:156 or .A:158 or .A:159 or .A:160 or .A:164 or .A:165 or .A:168 or .A:207 or .A:210 or .A:211 or .A:217; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J Med Chem. 2020 Mar 26;63(6):3227-3237. | ||||
| REF 2 | Crystal structure of the BRD7 bromodomain in complex with BI-9564 | ||||
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