Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T27457 Target Info
Target Name Gamma-actin (ACTG)
Synonyms Actin, cytoplasmic 2; ACTG
Target Type Literature-reported Target
Gene Name ACTG1
UniProt ID
ACTG_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Ademetionine Ligand Info
Structure Description SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine PDB:6WK2
Method X-ray diffraction Resolution 1.76 Å Mutation Yes [1]
PDB Sequence
TLKYPIEMGI
75
VTNWDDMEK
Residue
Distance (Å)
MET73
3.388
Residue
Distance (Å)
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution PDB:5JLH
Method Electron microscopy Resolution 3.90 Å Mutation No [2]
PDB Sequence
EEEIAALVID
10
NGSGMCKAGF
20
AGDDAPRAVF
30
PSIVGRPRHQ
40
GVMVGMGQKD
50

SYVGDEAQSK
60
RGILTLKYPI
70
EHGIVTNWDD
80
MEKIWHHTFY
90
NELRVAPEEH
100

PVLLTEAPLN
110
PKANREKMTQ
120
IMFETFNTPA
130
MYVAIQAVLS
140
LYASGRTTGI
150

VMDSGDGVTH
160
TVPIYEGYAL
170
PHAILRLDLA
180
GRDLTDYLMK
190
ILTERGYSFT
200

TTAEREIVRD
210
IKEKLCYVAL
220
DFEQEMATAA
230
SSSSLEKSYE
240
LPDGQVITIG
250

NERFRCPEAL
260
FQPSFLGMES
270
CGIHETTFNS
280
IMKCDVDIRK
290
DLYANTVLSG
300

GTTMYPGIAD
310
RMQKEITALA
320
PSTMKIKIIA
330
PPERKYSVWI
340
GGSILASLST
350

FQQMWISKQE
360
YDESGPSIVH
370
RKCF
Residue
Distance (Å)
ASP10
3.469
ASN11
4.797
GLY12
2.817
SER13
2.427
GLY14
4.433
MET15
3.496
LYS17
3.227
GLN136
4.335
GLY155
3.078
ASP156
2.560
GLY157
4.497
GLY181
3.417
Residue
Distance (Å)
ARG182
4.718
THR185
4.599
ARG209
3.653
LYS212
2.664
GLU213
2.945
LYS214
4.804
GLY300
3.778
GLY301
2.770
THR302
3.277
MET304
3.585
TYR305
3.052
LYS335
2.897
References  Top
REF 1 Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J Biol Chem. 2020 Aug 7;295(32):10901-10910.
REF 2 Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature. 2016 Jun 30;534(7609):724-8.

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