Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27602 | Target Info | |||
| Target Name | Cationic trypsinogen (PRSS1) | ||||
| Synonyms | Trypsin-1; Trypsin I; TRYP1; TRY1; TRP1; Serine protease 1; Beta-trypsin | ||||
| Target Type | Successful Target | ||||
| Gene Name | PRSS1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Phosphonotyrosine | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151 | PDB:1TRN | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
IVGGYNCEEN
25 SVPYQVSLNS37 GYHFCGGSLI47 NEQWVVSAGH57 CYKSRIQVRL67 GEHNIEVLEG 78 NEQFINAAKI88 IRHPQYDRKT98 LNNDIMLIKL108 SSRAVINARV118 STISLPTAPP 129 ATGTKCLISG140 WGNTASSGAD150 PDELQCLDAP161 VLSQAKCEAS171 YPGKITSNMF 181 CVGFLEGGKD189 SCQGDSGGPV199 VCNGQLQGVV213 SWGDGCAQKN223 KPGVYTKVYN 233 YVKWIKNTIA243 ANS
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| Ligand Name: Isopropyl dihydrogen phosphate | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151 | PDB:1TRN | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
IVGGYNCEEN
25 SVPYQVSLNS37 GYHFCGGSLI47 NEQWVVSAGH57 CYKSRIQVRL67 GEHNIEVLEG 78 NEQFINAAKI88 IRHPQYDRKT98 LNNDIMLIKL108 SSRAVINARV118 STISLPTAPP 129 ATGTKCLISG140 WGNTASSGAD150 PDELQCLDAP161 VLSQAKCEAS171 YPGKITSNMF 181 CVGFLEGGKD189 SCQGDSGGPV199 VCNGQLQGVV213 SWGDGCAQKN223 KPGVYTKVYN 233 YVKWIKNTIA243 ANS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. J Mol Biol. 1996 Jun 28;259(5):995-1010. | ||||
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