Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T27918 Target Info
Target Name ATP-dependent RNA helicase DDX5 (DDX5)
Synonyms RNA helicase p68; Probable ATP-dependent RNA helicase DDX5; HLR1; HELR; G17P1; DEAD box protein 5
Target Type Clinical trial Target
Gene Name DDX5
UniProt ID
DDX5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Human DEAD-BOX RNA helicase DDX5 (P68), conserved domain I in complex with ADP PDB:3FE2
Method X-ray diffraction Resolution 2.60 Å Mutation No [1]
PDB Sequence
QEVETYRRSK
80
EITVRGHNCP
90
KPVLNFYEAN
100
FPANVMDVIA
110
RQNFTEPTAI
120

QAQGWPVALS
130
GLDMVGVAQT
140
GSGKTLSYLL
150
PAIVHINHQP
160
FLERGDGPIC
170

LVLAPTRELA
180
QQVQQVAAEY
190
CRACRLKSTC
200
IYGGAPKGPQ
210
IRDLERGVEI
220

CIATPGRLID
230
FLECGKTNLR
240
RTTYLVLDEA
250
DRMLDMGFEP
260
QIRKIVDQIR
270

PDRQTLMWSA
280
TWPKEVRQLA
290
EDFLKDYIHI
300
NIGA
Residue
Distance (Å)
PHE96
3.645
PHE114
3.306
THR115
4.972
GLU116
2.712
PRO117
3.824
THR118
3.474
GLN121
2.818
GLN139
3.667
Residue
Distance (Å)
THR140
3.394
GLY141
2.484
SER142
3.145
GLY143
2.992
LYS144
2.746
THR145
2.350
LEU146
3.788
References  Top
REF 1 Comparative structural analysis of human DEAD-box RNA helicases. PLoS One. 2010 Sep 30;5(9):e12791.

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