Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30784 | Target Info | |||
| Target Name | Thrombospondin-1 (THBS1) | ||||
| Synonyms | TSP1; TSP; Glycoprotein G | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | THBS1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Beta-L-fucose | Ligand Info | |||||
| Structure Description | Crystal Structure of the Thrombospondin-1 Type 1 Repeats | PDB:1LSL | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
QDGGWSHWSP
425 WSSCSVTCGD435 GVITRIRLCN445 SPSPQMNGKP455 CEGEARETKA465 CKKDACPING 475 GWGPWSPWDI485 CSVTCGGGVQ495 KRSRLCNNPT505 PQFGGKDCVG515 DVTENQICNK 525 QDC
|
|||||
|
|
||||||
| Ligand Name: Selenomethionine | Ligand Info | |||||
| Structure Description | Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra | PDB:1ZA4 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
SVFDIFELTG
20 AARKGSGRRL30 VKGPDPSSPA40 FRIEDANLIP50 PVPDDKFQDL60 VDAVRTEKGF 70 LLLASLRQKK81 TRGTLLALER91 KDHSGQVFSV101 VSNGKAGTLD111 LSLTVQGKQH 121 VVSVEEALLA131 TGQWKSITLF141 VQEDRAQLYI151 DCEKENAELD162 VPIQSVFTRD 172 LASIARLRIA182 KGGVNDNFQG192 VLQNVRFVFG202 TTPEDILRNK212 GCS |
|||||
|
|
||||||
| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Crystal Structure of the Thrombospondin-1 Type 1 Repeats | PDB:1LSL | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
QDGGWSHWSP
425 WSSCSVTCGD435 GVITRIRLCN445 SPSPQMNGKP455 CEGEARETKA465 CKKDACPING 475 GWGPWSPWDI485 CSVTCGGGVQ495 KRSRLCNNPT505 PQFGGKDCVG515 DVTENQICNK 525 QDC
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FUC or .FUC2 or .FUC3 or :3FUC;style chemicals stick;color identity;select .A:489 or .A:490 or .A:528; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol. 2002 Oct 28;159(2):373-82. | ||||
| REF 2 | The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.