Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T30790 Target Info
Target Name Calcium-release activated calcium channel (CRACM)
Synonyms Transmembrane protein 142A; TMEM142A; Protein orai-1; Calcium release-activated calcium channel protein 1; CRACM1
Target Type Clinical trial Target
Gene Name ORAI1
UniProt ID
CRCM1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: gamma-butyrolactone Ligand Info
Structure Description Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode PDB:4EHQ
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
HSMQALSWRK
78
LYLSRAKLKA
88
Residue
Distance (Å)
LEU74
3.547
SER75
4.284
LYS78
3.354
Residue
Distance (Å)
LEU79
3.204
SER82
2.910
References  Top
REF 1 Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. J Biol Chem. 2012 Dec 14;287(51):43030-41.

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