Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T35824 Target Info
Target Name Matrix metalloproteinase-16 (MMP-16)
Synonyms Membrane-type-3 matrix metalloproteinase; Membrane-type matrix metalloproteinase 3; MTMMP3; MT3MMP; MT3-MMP; MT-MMP 3; MMPX2; MMP-X2; C8orf57
Target Type Literature-reported Target
Gene Name MMP16
Biochemical Class Peptidase
UniProt ID
MMP16_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Batimastat Ligand Info
Structure Description Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features PDB:1RM8
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
GQKWQHKHIT
133
YSIKNVTPKV
143
GDPETRKAIR
153
RAFDVWQNVT
163
PLTFEEVPYS
173

ELENGKRDVD
183
ITIIFASGFH
193
GDSSPFDGEG
203
GFLAHAYFPG
213
PGIGGDTHFD
223

SDEPWTLGNP
233
NHDGNDLFLV
243
AVHELGHALG
253
LEHSNDPTAI
263
MAPFYQYMET
273

DNFKLPNDDL
283
QGIQKIYGP
Residue
Distance (Å)
GLY204
2.980
PHE205
3.203
LEU206
2.789
ALA207
2.910
HIS208
3.867
ALA209
4.582
ASN238
4.912
VAL243
3.832
Residue
Distance (Å)
HIS246
3.143
GLU247
2.672
HIS250
2.997
HIS256
2.687
ALA265
3.736
PRO266
2.960
PHE267
3.484
TYR268
2.813
References  Top
REF 1 Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features. J Mol Biol. 2004 Feb 6;336(1):213-25.

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