Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T38134 Target Info
Target Name CaM-kinase IV kinase (CAMKK1)
Synonyms Calcium/calmodulin-dependent protein kinase kinase alpha; Calcium/calmodulin-dependent protein kinase kinase 1; CaMKK alpha; CaMKK 1; CaM-kinase kinase alpha; CaM-kinase kinase 1; CaM-KK alpha; CaM-KK 1; CAMKKA
Target Type Literature-reported Target
Gene Name CAMKK1
Biochemical Class Kinase
UniProt ID
KKCC1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: GSK-650394 Ligand Info
Structure Description Crystal Structure of the Human CAMKK1A in complex with GSK650394 PDB:6CD6
Method X-ray diffraction Resolution 2.20 Å Mutation No [1]
PDB Sequence
LNQYKLQSEI
134
GKGAYGVVRL
144
AYNESEDRHY
154
AMKVLSKKKL
164
LKQQLLPLER
195

VYQEIAILKK
205
LDHVNVVKLI
215
EVLDDPAEDN
225
LYLVFDLLRK
235
GPVMEVPCDK
245

PFSEEQARLY
255
LRDVILGLEY
265
LHCQKIVHRD
275
IKPSNLLLGD
285
DGHVKIADFG
295

VSNQFEGNDA
305
QLSSTAGTPA
315
FMAPEAISGQ
327
SFSGKALDVW
337
ATGVTLYCFV
347

YGKCPFIDDF
357
ILALHRKIKN
367
EPVVFPEEPE
377
ISEELKDLIL
387
KMLDKNPETR
397

IGVPDIKLHP
407
WVTK
Residue
Distance (Å)
ILE134
3.211
GLY135
3.919
LYS136
3.894
GLY137
3.568
ALA138
4.426
TYR139
3.934
VAL142
3.513
ALA155
3.274
LYS157
2.831
GLU199
4.184
VAL212
4.248
PHE230
3.447
ASP231
2.948
Residue
Distance (Å)
LEU232
3.680
LEU233
2.949
ARG234
4.248
LYS235
4.648
GLY236
3.455
PRO237
3.512
SER279
3.790
ASN280
3.704
LEU282
3.298
ALA292
4.153
ASP293
3.014
PHE294
4.092
GLY295
4.935
Ligand Name: N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE Ligand Info
Structure Description Crystal Structure of the Human CAMKK1A in complex with Hesperadin PDB:6CCF
Method X-ray diffraction Resolution 2.10 Å Mutation No [2]
PDB Sequence
MQLNQYKLQS
132
EIGKGAYGVV
142
RLAYNESEDR
152
HYAMKVLSKK
162
KLERVYQEIA
201

ILKKLDHVNV
211
VKLIEVLDDP
221
AEDNLYLVFD
231
LLRKGPVMEV
241
PCDKPFSEEQ
251

ARLYLRDVIL
261
GLEYLHCQKI
271
VHRDIKPSNL
281
LLGDDGHVKI
291
ADFGVSNQFE
301

GNDAQLSSTA
311
GTPAFMAPEA
321
ISDSGQSFSG
331
KALDVWATGV
341
TLYCFVYGKC
351

PFIDDFILAL
361
HRKIKNEPVV
371
FPEEPEISEE
381
LKDLILKMLD
391
KNPETRIGVP
401

DIKLHPWVTK
411
Residue
Distance (Å)
ILE134
3.459
GLY135
3.820
TYR139
3.714
VAL142
3.467
ALA155
3.402
LYS157
2.820
VAL212
3.649
PHE230
3.416
ASP231
2.953
LEU232
3.473
Residue
Distance (Å)
LEU233
2.832
ARG234
3.375
LYS235
4.642
GLY236
3.640
PRO237
3.942
SER279
4.240
ASN280
3.527
LEU282
3.508
ALA292
3.989
ASP293
3.334
References  Top
REF 1 Crystal Structure of the Human CAMKK1A in complex with GSK650394
REF 2 Crystal Structure of the Human CAMKK1A in complex with Hesperadin

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