Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T40488 Target Info
Target Name Matrix metalloproteinase-10 (MMP-10)
Synonyms Transin-2; Stromelysin-2; STMY2; SL-2
Target Type Patented-recorded Target
Gene Name MMP10
Biochemical Class Peptidase
UniProt ID
MMP10_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid Ligand Info
Structure Description Crystal structure of the catalytic domain of human matrix metalloproteinase 10 PDB:1Q3A
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [1]
PDB Sequence
MPKWRKTHLT
114
YRIVNYTPDL
124
PRDAVDSAIE
134
KALKVWEEVT
144
PLTFSRLYEG
154

EADIMISFAV
164
KEHGDNYSFD
174
GPGHSLAHAY
184
PPGPGLYGDI
194
HFDDDEKWTE
204

DASGTNLFLV
214
AAHELGHSLG
224
LFHSANTEAL
234
MYPLYNSLAQ
247
FRLSQDDVNG
257

IQSLYG
Residue
Distance (Å)
HIS178
3.492
SER179
3.042
LEU180
2.172
ALA181
2.567
HIS182
4.003
LEU213
3.661
VAL214
3.720
HIS217
3.101
GLU218
2.407
Residue
Distance (Å)
HIS221
3.568
HIS227
3.003
LEU234
3.920
TYR236
4.243
PRO237
3.180
LEU238
4.013
TYR239
4.105
SER241
2.965
References  Top
REF 1 Crystal structure of the catalytic domain of human matrix metalloproteinase 10. J Mol Biol. 2004 Feb 20;336(3):707-16.

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