Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T42025 Target Info
Target Name Estrogen-related receptor-beta (ESRRB)
Synonyms Steroid hormone receptor ERR2; Nuclear receptor subfamily 3 group B member 2; NR3B2; Estrogen-related receptor beta; Estrogen receptor-like 2; ESRL2; ERRB2; ERR-beta; ERR beta-2
Target Type Literature-reported Target
Gene Name ESRRB
Biochemical Class Nuclear hormone receptor
UniProt ID
ERR2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Bisphenol A Ligand Info
Structure Description Estrogen-related receptor beta(ERR2) in complex with BPA PDB:6LIT
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [1]
PDB Sequence
GDIKALTTLC
244
DLADRELVVI
254
IGWAKHIPGF
264
SSLSLGDQMS
274
LLQSAWMEIL
284

ILGIVYRSLP
294
YDDKLVYAED
304
YIMDEEHSRL
314
AGLLELYRAI
324
LQLVRRYKKL
334

KVEKEEFVTL
344
KALALANSDS
354
MHIEDLEAVQ
364
KLQDLLHEAL
374
QDYELSQHHE
384

EPWRTGKLLL
394
TLPLLRQTAA
404
KAVQHFYSVK
414
LQGKVPMHKL
424
FLEMLEAK
Residue
Distance (Å)
LEU243
3.138
CYS244
4.305
LEU246
3.959
ALA247
3.603
GLU250
3.810
MET281
3.517
LEU284
4.052
ILE288
3.559
ARG291
3.181
Residue
Distance (Å)
TYR301
3.095
LEU317
4.140
LEU320
3.340
TYR321
4.688
ILE324
3.693
ALA406
4.179
PHE410
3.464
PHE425
4.205
References  Top
REF 1 Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta. J Mol Biol. 2020 Sep 4;432(19):5460-5472.

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