Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44515 | Target Info | |||
| Target Name | Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC) | ||||
| Synonyms | nadC; Quinolinic acid phosphoribosyltransferase; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MycB nadC | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-Phosphoribosyl-1-(Beta-Methylene) Pyrophosphate | Ligand Info | |||||
| Structure Description | QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP | PDB:1QPR | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [1] |
| PDB Sequence |
GLSDWELAAA
11 RAAIARGLDE21 DLRYGPDVTT31 LATVPASATT41 TASLVTREAG51 VVAGLDVALL 61 TLNEVLGTNG71 YRVLDRVEDG81 ARVPPGEALM91 TLEAQTRGLL101 TAERTMLNLV 111 GHLSGIATAT121 AAWVDAVRGT131 KAKIRDTRKT141 LPGLRALQKY151 AVRTGGGVNH 161 RLGLGDAALI171 KDNHVAAAGS181 VVDALRAVRN191 AAPDLPCEVE201 VDSLEQLDAV 211 LPEKPELILL221 DNFAVWQTQT231 AVQRRDSRAP241 TVMLESSGGL251 SLQTAATYAE 261 TGVDYLAVGA271 LTHSVRVLDI281 GLDM
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| Ligand Name: Phthalic acid | Ligand Info | |||||
| Structure Description | QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP | PDB:1QPR | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [1] |
| PDB Sequence |
GLSDWELAAA
11 RAAIARGLDE21 DLRYGPDVTT31 LATVPASATT41 TASLVTREAG51 VVAGLDVALL 61 TLNEVLGTNG71 YRVLDRVEDG81 ARVPPGEALM91 TLEAQTRGLL101 TAERTMLNLV 111 GHLSGIATAT121 AAWVDAVRGT131 KAKIRDTRKT141 LPGLRALQKY151 AVRTGGGVNH 161 RLGLGDAALI171 KDNHVAAAGS181 VVDALRAVRN191 AAPDLPCEVE201 VDSLEQLDAV 211 LPEKPELILL221 DNFAVWQTQT231 AVQRRDSRAP241 TVMLESSGGL251 SLQTAATYAE 261 TGVDYLAVGA271 LTHSVRVLDI281 GLDM
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| Ligand Name: Quinolinic acid | Ligand Info | |||||
| Structure Description | Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target | PDB:1QPQ | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [1] |
| PDB Sequence |
GLSDWELAAA
11 RAAIARGLDE21 DLRYGPDVTT31 LATVPASATT41 TASLVTREAG51 VVAGLDVALL 61 TLNEVLGTNG71 YRVLDRVEDG81 ARVPPGEALM91 TLEAQTRGLL101 TAERTMLNLV 111 GHLSGIATAT121 AAWVDAVRGT131 KAKIRDTRKT141 LPGLRALQKY151 AVRTGGGVNH 161 RLGLGDAALI171 KDNHVAAAGS181 VVDALRAVRN191 AAPDLPCEVE201 VDSLEQLDAV 211 LPEKPELILL221 DNFAVWQTQT231 AVQRRDSRAP241 TVMLESSGGL251 SLQTAATYAE 261 TGVDYLAVGA271 LTHSVRVLDI281 GLDM
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NTM or .NTM2 or .NTM3 or :3NTM;style chemicals stick;color identity;select .A:137 or .A:138 or .A:139 or .A:140 or .A:161 or .A:162 or .A:170 or .A:172 or .A:220 or .A:248 or .A:268; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Namn | Ligand Info | |||||
| Structure Description | Quinolinate Phosphoribosyl Transferase from Mycobacterium Tuberculosis in Complex with NCNN | PDB:1QPN | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
GLSDWELAAA
11 RAAIARGLDE21 DLRYGPDVTT31 LATVPASATT41 TASLVTREAG51 VVAGLDVALL 61 TLNEVLGTNG71 YRVLDRVEDG81 ARVPPGEALM91 TLEAQTRGLL101 TAERTMLNLV 111 GHLSGIATAT121 AAWVDAVRGT131 KAKIRDTRKT141 LPGLRALQKY151 AVRTGGGVNH 161 RLGLGDAALI171 KDNHVAAAGS181 VVDALRAVRN191 AAPDLPCEVE201 VDSLEQLDAV 211 LPEKPELILL221 DNFAVWQTQT231 AVQRRDSRAP241 TVMLESSGGL251 SLQTAATYAE 261 TGVDYLAVGA271 LTHSVRVLDI281 GLDM
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NCN or .NCN2 or .NCN3 or :3NCN;style chemicals stick;color identity;select .A:137 or .A:138 or .A:139 or .A:140 or .A:161 or .A:162 or .A:201 or .A:220 or .A:222 or .A:246 or .A:248 or .A:249 or .A:268 or .A:269 or .A:270 or .A:271 or .A:274; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure. 1998 Dec 15;6(12):1587-99. | ||||
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