Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T46781 Target Info
Target Name Aurora kinase B (AURKB)
Synonyms Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; STK5; STK12; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK2; ARK-2; AIRK2; AIM1; AIM-1; AIK2
Target Type Clinical trial Target
Gene Name AURKB
Biochemical Class Kinase
UniProt ID
AURKB_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: VX-680 Ligand Info
Structure Description Human Aurora B Kinase in complex with INCENP and VX-680 PDB:4AF3
Method X-ray diffraction Resolution 2.75 Å Mutation Yes [1]
PDB Sequence
RHFTIDDFEI
79
GRPLGKGKFG
89
NVYLAREKKS
99
HFIVALKVLF
109
KSQIEKEGVE
119

HQLRREIEIQ
129
AHLHHPNILR
139
LYNYFYDRRR
149
IYLILEYAPR
159
GELYKELQKS
169

CTFDEQRTAT
179
IMEELADALM
189
YCHGKKVIHR
199
DIKPENLLLG
209
LKGELKIADF
219

GLDYLPPEMI
245
EGRMHNEKVD
255
LWCIGVLCYE
265
LLVGNPPFES
275
ASHNETYRRI
285

VKVDLKFPAS
295
VPTGAQDLIS
305
KLLRHNPSER
315
LPLAQVSAHP
325
WVRANSRRVL
335

PPS
Residue
Distance (Å)
LEU83
3.369
GLY84
4.112
PHE88
3.208
VAL91
3.704
ALA104
3.407
LYS106
3.359
LEU138
3.958
LEU154
3.922
GLU155
2.882
TYR156
3.242
Residue
Distance (Å)
ALA157
2.889
PRO158
3.086
ARG159
4.077
GLY160
3.350
GLU161
3.976
GLU204
4.861
LEU207
3.481
ALA217
4.255
ASP218
4.918
PHE219
3.991
References  Top
REF 1 Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem. 2012 Sep 13;55(17):7841-8.

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