Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T47351 Target Info
Target Name ADP-ribosylation factor 1 (ARF1)
Synonyms PVNH8
Target Type Literature-reported Target
Gene Name ARF1
Biochemical Class Small GTPase
UniProt ID
ARF1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Diphosphate Ligand Info
Structure Description HUMAN ADP-RIBOSYLATION FACTOR 1 COMPLEXED WITH GDP, FULL LENGTH NON-MYRISTOYLATED PDB:1HUR
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
GNIFANLFKG
11
LFGKKEMRIL
21
MVGLDAAGKT
31
TILYKLKLGE
41
IVTTIPTIGF
51

NVETVEYKNI
61
SFTVWDVGGQ
71
DKIRPLWRHY
81
FQNTQGLIFV
91
VDSNDRERVN
101

EAREELMRML
111
AEDELRDAVL
121
LVFANKQDLP
131
NAMNAAEITD
141
KLGLHSLRHR
151

NWYIQATCAT
161
SGDGLYEGLD
171
WLSNQLRNQK
181
Residue
Distance (Å)
LEU25
4.141
ASP26
3.566
ALA27
2.481
ALA28
2.814
GLY29
2.928
LYS30
3.028
THR31
2.961
THR32
2.765
GLU54
4.576
ASP67
4.222
Residue
Distance (Å)
ASN126
3.147
LYS127
3.142
GLN128
4.481
ASP129
2.746
LEU130
3.553
THR158
4.538
CYS159
3.226
ALA160
2.986
THR161
3.721
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Ligand Name: Guanosine-5'-Triphosphate Ligand Info
Structure Description phospho-STING binding to adaptor protein complex-1 PDB:7R4H
Method Electron microscopy Resolution 2.34 Å Mutation Yes [2]
PDB Sequence
EMRILMVGLD
26
AAGKTTILYK
36
LKLGEIVTTI
46
PTIGFNVETV
56
EYKNISFTVW
66

DVGGLDKIRP
76
LWRHYFQNTQ
86
GLIFVVDSND
96
RERVNEAREE
106
LMRMLAEDEL
116

RDAVLLVFAN
126
KQDLPNAMNA
136
AEITDKLGLH
146
SLRHRNWYIQ
156
ATCATSGDGL
166

YEGLDWLSNQ
176
LRNQK
Residue
Distance (Å)
LEU25
3.230
ASP26
3.357
ALA27
2.712
ALA28
3.621
GLY29
2.197
LYS30
1.300
THR31
2.885
THR32
3.761
ILE42
3.488
THR45
3.395
ILE46
3.995
PRO47
3.479
Residue
Distance (Å)
THR48
1.374
ILE49
4.936
ASP67
4.247
VAL68
4.858
GLY69
3.558
GLY70
3.713
LEU71
3.826
LYS127
1.349
ASP129
4.611
CYS159
4.975
ALA160
1.375
THR161
3.932
Ligand Name: brefeldin A Ligand Info
Structure Description Structure of ARF1-GDP bound to Sec7 domain complexed with Brefeldin A PDB:1RE0
Method X-ray diffraction Resolution 2.40 Å Mutation No [3]
PDB Sequence
MRILMVGLDA
27
AGKTTILYKL
37
KLGEIVTTIP
47
TIGFNVETVE
57
YKNISFTVWD
67

VGGQDKIRPL
77
WRHYFQNTQG
87
LIFVVDSNDR
97
ERVNEAREEL
107
MRMLAEDELR
117

DAVLLVFANK
127
QDLPNAMNAA
137
EITDKLGLHS
147
LRHRNWYIQA
157
TCATSGDGLY
167

EGLDWLSNQL
177
RN
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Residue
Distance (Å)
PHE51
3.737
ASN52
3.922
VAL53
3.445
GLU54
4.400
THR64
3.682
VAL65
3.481
Residue
Distance (Å)
TRP66
3.312
ASP67
3.157
GLY69
4.550
ILE74
3.472
TRP78
3.083
TYR81
3.535
References  Top
REF 1 Structure of the human ADP-ribosylation factor 1 complexed with GDP. Nature. 1994 Dec 15;372(6507):704-8.
REF 2 Clathrin-associated AP-1 controls termination of STING signalling. Nature. 2022 Oct;610(7933):761-767.
REF 3 Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell. 2003 Dec;12(6):1403-11.

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