Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53468 | Target Info | |||
| Target Name | WNK lysine-deficient protein kinase 3 (WNK3) | ||||
| Synonyms | Serine/threonine-protein kinase WNK3; Protein kinase with no lysine 3; Protein kinase lysine-deficient 3; KIAA1566 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | WNK3 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: PP121 | Ligand Info | |||||
| Structure Description | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121 | PDB:5O2B | ||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [1] |
| PDB Sequence |
MEAEMKAVAT
140 SPSGRFLKFD150 IELGRGAFKT160 VYKGLDTETW170 VEVAWCELQL183 TKAEQQRFKE 193 EAEMLKGLQH203 PNIVRFYDSW213 ESIKCIVLVT227 ELMTSGTLKT237 YLKRFKVMKP 247 KVLRSWCRQI257 LKGLQFLHTR267 TPPIIHRDLK277 CDNIFITGPT287 GSVKIGDLGL 297 ATLMIGTPEF315 MAPEMYEEHY325 DESVDVYAFG335 MCMLEMATSE345 YPYSECQNAA 355 QIYRKVTSGI365 KPASFNKVTD375 PEVKEIIEGC385 IRQNKSERLS395 IRDLLNHAFF 405 AEDTGLRVE
|
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GLY154
3.996
ARG155
3.920
GLY156
4.013
LYS159
2.807
VAL161
3.502
ALA174
3.643
CYS176
4.109
VAL207
3.969
LEU225
3.789
THR227
2.996
|
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| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ | PDB:5O26 | ||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | No | [2] |
| PDB Sequence |
MKAVATSPSG
144 RFLKFDIELG154 RGAFKTVYKG164 LDTETWVEVA174 WCELQDTKAE187 QQRFKEEAEM 197 LKGLQHPNIV207 RFYDSWESIK221 CIVLVTELMT231 SGTLKTYLKR241 FKVMKPKVLR 251 SWCRQILKGL261 QFLHTRTPPI271 IHRDLKCDNI281 FITGPTGSVK291 IGDLGLATLM 301 RTFAKVIGTP313 EFMAPEMYEE323 HYDESVDVYA333 FGMCMLEMAT343 SEYPYSECQN 353 AAQIYRKVTS363 GIKPASFNKV373 TDPEVKEIIE383 GCIRQNKSER393 LSIRDLLNHA 403 FFAEDTGLRV413 E
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GLY154
3.777
ARG155
3.706
GLY156
3.377
ALA157
2.966
PHE158
2.824
LYS159
2.933
VAL161
3.418
ALA174
3.823
CYS176
4.801
THR227
4.053
GLU228
3.161
|
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| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ | PDB:5O26 | ||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | No | [2] |
| PDB Sequence |
MKAVATSPSG
144 RFLKFDIELG154 RGAFKTVYKG164 LDTETWVEVA174 WCELQDTKAE187 QQRFKEEAEM 197 LKGLQHPNIV207 RFYDSWESIK221 CIVLVTELMT231 SGTLKTYLKR241 FKVMKPKVLR 251 SWCRQILKGL261 QFLHTRTPPI271 IHRDLKCDNI281 FITGPTGSVK291 IGDLGLATLM 301 RTFAKVIGTP313 EFMAPEMYEE323 HYDESVDVYA333 FGMCMLEMAT343 SEYPYSECQN 353 AAQIYRKVTS363 GIKPASFNKV373 TDPEVKEIIE383 GCIRQNKSER393 LSIRDLLNHA 403 FFAEDTGLRV413 E
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121 | ||||
| REF 2 | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ | ||||
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