Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53562 | Target Info | |||
| Target Name | X-ray repair cross-complementing 5 (Ku80) | ||||
| Synonyms | X-ray repair cross-complementing protein 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); Thyroid-lupus autoantigen; TLAA; Nuclear factor IV; Lupus Ku autoantigen protein p86; Ku86; G22P2; DNA repair protein XRCC5; CTCBF; CTC85; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; 86 kDa subunit of Ku antigen | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | XRCC5 | ||||
| Biochemical Class | Acid anhydride hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Myo-inositol hexaphosphate | Ligand Info | |||||
| Structure Description | DNA-PK complex of DNA end processing | PDB:7SGL | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NKAAVVLCMD
15 VGFTMSNSIP25 GIESPFEQAK35 KVITMFVQRQ45 VFAENKDEIA55 LVLFGTDGTD 65 NPLSGGDQYQ75 NITVHRHLML85 PDFDLLEDIE95 SKIQPGSQQA105 DFLDALIVSM 115 DVIQHETIGK125 KFEKRHIEIF135 TDLSSRFSKS145 QLDIIIHSLK155 KCDISLQFFL 165 PFSLPFRLGG187 HGPSFPLKGI197 TEQQKEGLEI207 VKMVMISLEG217 EDGLDEIYSF 227 SESLRKLCVF237 KKIERHSIHW247 PCRLTIGSNL257 SIRIAAYKSI267 LQERVKKTWT 277 VVDAKTLKKE287 DIQKETVYCL297 NDDDETEVLK307 EDIIQGFRYG317 SDIVPFSKVD 327 EEQMKYKSEG337 KCFSVLGFCK347 SSQVQRRFFM357 GNQVLKVFAA367 RDDEAAAVAL 377 SSLIHALDDL387 DMVAIVRYAY397 DKRANPQVGV407 AFPHIKHNYE417 CLVYVQLPFM 427 EDLRQYMFSS437 LKNSKKYAPT447 EAQLNAVDAL457 IDSMSLAKKD467 EKTDTLEDLF 477 PTTKIPNPRF487 QRLFQCLLHR497 ALHPREPLPP507 IQQHIWNMLN517 PPAEVTTKSQ 527 IPLSKIKTLF537 PLIEAKKKDQ547 VTAQEIFQAE596 NFRVLVKQKK606 ASFEEASNQL 616 INHIEQFLDT626 NETPYFMKSI636 DCIRAFREEA646 IKFSEEQRFN656 NFLKALQEKV 666 EIKQLNHFWE676 IVDVDDLLDM731 I
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol Cell. 2022 Jan 6;82(1):177-189.e4. | ||||
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