Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57006 Target Info
Target Name Ephrin type-A receptor 7 (EPHA7)
Synonyms hEK11; EPH-like kinase 11; EPH homology kinase 3; EK11; EHK3; EHK-3
Target Type Literature-reported Target
Gene Name EPHA7
Biochemical Class Kinase
UniProt ID
EPHA7_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 5-[(2-Methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Ligand Info
Structure Description Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7 PDB:3DKO
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
TYIDPETYED
616
PNRAVHQFAK
626
ELDASCIKIE
636
RVIGAEFGEV
647
CSGRLKLPGK
657

RDVAVAIKTL
667
KVGYTEKQRR
677
DFLCEASIMG
687
QFDHPNVVHL
697
EGVVTRGKPV
707

MIVIEFMENG
717
ALDAFLRKHD
727
GQFTVIQLVG
737
MLRGIAAGMR
747
YLADMGYVHR
757

DLAARNILVN
767
SNLVCKVSDF
777
GPVRWTAPEA
807
IQYRKFTSAS
817
DVWSYGIVMW
827

EVMSYGERPY
837
WDMSNQDVIK
847
AIEEGYRLPA
857
PMDCPAGLHQ
867
LMLDCWQKER
877

AERPKFEQIV
887
GILDKMIRNP
897
NSAHH
Residue
Distance (Å)
ILE639
4.024
VAL647
3.281
ALA663
3.345
LYS665
3.862
GLU682
2.751
ILE685
4.105
MET686
3.563
PHE689
3.602
VAL694
3.735
VAL695
3.332
ILE711
3.692
GLU712
3.409
Residue
Distance (Å)
PHE713
3.983
MET714
3.021
GLY717
3.906
ALA718
4.959
LEU749
4.734
TYR754
3.680
HIS756
4.053
LEU765
3.390
VAL774
3.579
SER775
2.837
ASP776
2.903
PHE777
3.672
References  Top
REF 1 Kinase domain of human ephrin type-a receptor 7 (epha7) in complex with ALW-II-49-7

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