Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57291 | Target Info | |||
| Target Name | PP2A B subunit isoform R5-alpha (PPP2R5A) | ||||
| Synonyms | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; Protein phosphatase-2A; PR61alpha; PP2A, B subunit, R5 alpha isoform; PP2A, B subunit, PR61 alpha isoform; PP2A, B subunit, B56 alpha isoform; PP2A, B subunit, B' alpha isoform; PP2A B subunit isoform PR61-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform B'-alpha | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PPP2R5A | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Methyl L-leucinate | Ligand Info | |||||
| Structure Description | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | PDB:6NTS | ||||
| Method | Electron microscopy | Resolution | 3.63 Å | Mutation | No | [1] |
| PDB Sequence |
QELFCQKLQQ
77 CCILFDFMDS87 VSDLKSKEIK97 RATLNELVEY107 VSTNRGVIVE117 SAYSDIVKMI 127 SANIFRTLPP137 SDNPDFDPEE147 DEPTLEASWP157 HIQLVYEFFL167 RFLESPDFQP 177 SIAKRYIDQK187 FVQQLLELFD197 SEDPRERDFL207 KTVLHRIYGK217 FLGLRAFIRK 227 QINNIFLRFI237 YETEHFNGVA247 ELLEILGSII257 NGFALPLKAE267 HKQFLMKVLI 277 PMHTAKGLAL287 FHAQLAYCVV297 QFLEKDTTLT307 EPVIRGLLKF317 WPKTCSQKEV 327 MFLGEIEEIL337 DVIEPTQFKK347 IEEPLFKQIS357 KCVSSSHFQV367 AERALYFWNN 377 EYILSLIEEN387 IDKILPIMFA397 SLYKISKEHW407 NPTIVALVYN417 VLKTLMEMNG 427 K
|
|||||
|
|
||||||
| Ligand Name: N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide | Ligand Info | |||||
| Structure Description | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | PDB:6NTS | ||||
| Method | Electron microscopy | Resolution | 3.63 Å | Mutation | No | [1] |
| PDB Sequence |
QELFCQKLQQ
77 CCILFDFMDS87 VSDLKSKEIK97 RATLNELVEY107 VSTNRGVIVE117 SAYSDIVKMI 127 SANIFRTLPP137 SDNPDFDPEE147 DEPTLEASWP157 HIQLVYEFFL167 RFLESPDFQP 177 SIAKRYIDQK187 FVQQLLELFD197 SEDPRERDFL207 KTVLHRIYGK217 FLGLRAFIRK 227 QINNIFLRFI237 YETEHFNGVA247 ELLEILGSII257 NGFALPLKAE267 HKQFLMKVLI 277 PMHTAKGLAL287 FHAQLAYCVV297 QFLEKDTTLT307 EPVIRGLLKF317 WPKTCSQKEV 327 MFLGEIEEIL337 DVIEPTQFKK347 IEEPLFKQIS357 KCVSSSHFQV367 AERALYFWNN 377 EYILSLIEEN387 IDKILPIMFA397 SLYKISKEHW407 NPTIVALVYN417 VLKTLMEMNG 427 K
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell. 2020 Apr 30;181(3):688-701.e16. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.