Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T58178 Target Info
Target Name Glutamate receptor ionotropic kainate 2 (GRIK2)
Synonyms Glutamate receptor ionotropic, kainate 2; Glutamate receptor 6; GluR6; GluR-6; GluK2; Excitatory amino acid receptor 4; EAA4
Target Type Literature-reported Target
Gene Name GRIK2
Biochemical Class Glutamate-gated ion channel
UniProt ID
GRIK2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2r,3ar,6r,7r,7ar)-2-[(2s)-2-Amino-2-Carboxyethyl]-6,7-Dihydroxyhexahydro-2h-Furo[3,2-B]pyran-2-Carboxylic Acid Ligand Info
Structure Description Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A PDB:3QXM
Method X-ray diffraction Resolution 1.65 Å Mutation No [1]
PDB Sequence
RSLIVTTILE
409
EPYVLFKKSD
419
KPLYGNDRFE
429
GYCIDLLREL
439
STILGFTYEI
449

RLVEDGKYGA
459
QDDANGQWNG
469
MVRELIDHKA
479
DLAVAPLAIT
489
YVREKVIDFS
499

KPFMTLGISI
509
LYRKGTPIDS
639
ADDLAKQTKI
649
EYGAVEDGAT
659
MTFFKKSKIS
669

TYDKMWAFMS
679
SRRQSVLVKS
689
NEEGIQRVLT
699
SDYAFLMEST
709
TIEFVTQRNC
719

NLTQIGGLID
729
SKGYGVGTPM
739
GSPYRDKITI
749
AILQLQEEGK
759
LHMMKEKWWR
769
Residue
Distance (Å)
GLU409
3.548
TYR412
4.474
TYR457
3.269
PRO485
2.831
LEU486
3.527
ALA487
2.862
ARG492
2.733
VAL654
3.420
ASP656
4.925
GLY657
3.495
Residue
Distance (Å)
ALA658
2.813
THR659
2.628
MET660
4.597
ASN690
3.294
PHE704
3.940
MET706
3.495
GLU707
2.763
THR710
2.681
TYR733
3.860
References  Top
REF 1 Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors. J Mol Biol. 2011 Oct 28;413(3):667-83.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.