Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59729 | Target Info | |||
| Target Name | Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2) | ||||
| Synonyms | asd2; L-Aspartate-beta-semialdehyde dehydrogenase; ASADH; ASA dehydrogenase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Bact asd2 | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (4S)-4-{[(2S)-2-Amino-3-oxopropyl]sulfanyl}-L-homoserine | Ligand Info | |||||
| Structure Description | crystal structure of aspartate semialdehyde dehydrogenase II complexed with ASA from vibrio cholerae | PDB:2R00 | ||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [1] |
| PDB Sequence |
SQQFNVAIFG
12 ATGAVGETML22 EVLQEREFPV32 DELFLLASER42 SEGKTYRFNG52 KTVRVQNVEE 62 FDWSQVHIAL72 FSAGGELSAK82 WAPIAAEAGV92 VVIDNTSHFR102 YDYDIPLVVP 112 EVNPEAIAEF122 RNRNIIANPN132 STIQMLVALK143 PIYDAVGIER153 INVTTYQSVS 163 GAGKAGIDEL173 AGQTAKLLNG183 YPAETNTFSQ193 QIAFNCIPQI203 DQFMDNGYTK 213 EEMKMVWETQ223 KIFNDPSIMV233 NPTCVRVPVF243 YGHAEAVHVE253 TRAPIDAEQV 263 MDMLEQTDGI273 ELFRGADFPT283 QVRDAGGKDH293 VLVGRVRNDI303 SHHSGINLWV 313 VADNVRKGAA323 TNAVQIAELL333 VRDYF
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| Ligand Name: Diglycolic acid | Ligand Info | |||||
| Structure Description | crystal structure of aspartate semialdehyde dehydrogenase II complexed with ASA from vibrio cholerae | PDB:2R00 | ||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [1] |
| PDB Sequence |
SQQFNVAIFG
12 ATGAVGETML22 EVLQEREFPV32 DELFLLASER42 SEGKTYRFNG52 KTVRVQNVEE 62 FDWSQVHIAL72 FSAGGELSAK82 WAPIAAEAGV92 VVIDNTSHFR102 YDYDIPLVVP 112 EVNPEAIAEF122 RNRNIIANPN132 STIQMLVALK143 PIYDAVGIER153 INVTTYQSVS 163 GAGKAGIDEL173 AGQTAKLLNG183 YPAETNTFSQ193 QIAFNCIPQI203 DQFMDNGYTK 213 EEMKMVWETQ223 KIFNDPSIMV233 NPTCVRVPVF243 YGHAEAVHVE253 TRAPIDAEQV 263 MDMLEQTDGI273 ELFRGADFPT283 QVRDAGGKDH293 VLVGRVRNDI303 SHHSGINLWV 313 VADNVRKGAA323 TNAVQIAELL333 VRDYF
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):321-30. | ||||
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