Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T60930 Target Info
Target Name Insulin-like growth factor-I (IGF1)
Synonyms SomatomedinC; Somatomedin-C; Mechano growth factor; Insulin-like growth factor I; IGFI; IGF-I
Target Type Clinical trial Target
Gene Name IGF1
UniProt ID
IGF1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Deoxy-Bigchap Ligand Info
Structure Description 1.8 Angstrom crystal structure of IGF-1 PDB:1IMX
Method X-ray diffraction Resolution 1.82 Å Mutation No [1]
PDB Sequence
ETLCGAELVD
12
ALQFVCGDRG
22
FYFNKPTGYG
32
SSTGIVDECC
48
FRSCDLRRLE
58

MYCAPL
Residue
Distance (Å)
GLU3
3.065
THR4
3.628
LEU5
3.426
ASP12
3.910
ALA13
3.825
PHE16
3.556
Residue
Distance (Å)
VAL17
3.804
CYS47
4.916
CYS52
3.535
ASP53
4.378
LEU54
3.777
LEU57
3.958
References  Top
REF 1 Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions. Biochemistry. 2001 Sep 18;40(37):11022-9.

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