Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66903 | Target Info | |||
| Target Name | Fascin (FSCN1) | ||||
| Synonyms | Singed-like protein; SNL; HSN; FAN1; 55 kDa actin-bundling protein; 55 kDa actin bundling protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | FSCN1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-[(3,4-dichlorophenyl)methyl]-4-oxo-1-piperidin-4-yl-N-pyridin-4-ylpyrazolo[4,3-c]pyridine-7-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176 | PDB:6I18 | ||||
| Method | X-ray diffraction | Resolution | 1.49 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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| Ligand Name: 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-6-piperidin-4-yl-2,7-naphthyridine-4-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24 | PDB:6I17 | ||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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| Ligand Name: 2-[(4-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 5 | PDB:6I12 | ||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H08 or .H082 or .H083 or :3H08;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:62 or .A:93 or .A:94 or .A:95 or .A:101 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217 or .A:224; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-benzyl-N-(1-methyl-1H-pyrazol-4-yl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3 | PDB:6I11 | ||||
| Method | X-ray diffraction | Resolution | 1.67 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H0H or .H0H2 or .H0H3 or :3H0H;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:50 or .A:60 or .A:93 or .A:94 or .A:95 or .A:101 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217 or .A:224; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9 | PDB:6I14 | ||||
| Method | X-ray diffraction | Resolution | 1.73 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GZN or .GZN2 or .GZN3 or :3GZN;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:62 or .A:93 or .A:94 or .A:95 or .A:101 or .A:102 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217 or .A:224; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(2,4-dichlorophenyl)-N-methylacetamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1 | PDB:6I0Z | ||||
| Method | X-ray diffraction | Resolution | 1.77 Å | Mutation | No | [1] |
| PDB Sequence |
TAEAVQIQFG
15 LINCGNKYLT25 AEAFGFKVNA35 SASSLKKKQI45 WTLEQPPDEA55 GSAAVCLRSH 65 LGRYLAADKD75 GNVTCEREVP85 GPDCRFLIVA95 HDDGRWSLQS105 EAHRRYFGGT 115 EDRLSCFAQT125 VSPAEKWSVH135 IAMHPQVNIY145 SVTRKRYAHL155 SARPADEIAV 165 DRDVPWGVDS175 LITLAFQDQR185 YSVQTADHRF195 LRHDGRLVAR205 PEPATGYTLE 215 FRSGKVAFRD225 CEGRYLAPSG235 PSGTLKAGKA245 TKVGKDELFA255 LEQSCAQVVL 265 QAANERNVST275 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GZQ or .GZQ2 or .GZQ3 or :3GZQ;style chemicals stick;color identity;select .A:12 or .A:14 or .A:16 or .A:48 or .A:62 or .A:93 or .A:101 or .A:103 or .A:134 or .A:136 or .A:181 or .A:186 or .A:213 or .A:214 or .A:216; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 2-[(3-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7 | PDB:6I13 | ||||
| Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H0Q or .H0Q2 or .H0Q3 or :3H0Q;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:93 or .A:94 or .A:95 or .A:101 or .A:102 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-N-methyl-2-oxo-1,2-dihydro-3-pyridinecarboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11 | PDB:6I15 | ||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GZT or .GZT2 or .GZT3 or :3GZT;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:60 or .A:93 or .A:101 or .A:102 or .A:103 or .A:132 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 15 | PDB:6I16 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
VQIQFGLINC
19 GNKYLTAEAF29 GFKVNASASS39 LKKKQIWTLE49 QPPDEAGSAA59 VCLRSHLGRY 69 LAADKDGNVT79 CEREVPGPDC89 RFLIVAHDDG99 RWSLQSEAHR109 RYFGGTEDRL 119 SCFAQTVSPA129 EKWSVHIAMH139 PQVNIYSVTR149 KRYAHLSARP159 ADEIAVDRDV 169 PWGVDSLITL179 AFQDQRYSVQ189 TADHRFLRHD199 GRLVARPEPA209 TGYTLEFRSG 219 KVAFRDCEGR229 YLAPSGPSGT239 LKAGKATKVG249 KDELFALEQS259 CAQVVLQAAN 269 ERNVSTRQGM279 DLSANQDEET289 DQETFQLEID299 RDTKKCAFRT309 HTGKYWTLTA 319 TGGVQSTASS329 KNASCYFDIE339 WRDRRITLRA349 SNGKFVTSKK359 NGQLAASVET 369 AGDSELFLMK379 LINRPIIVFR389 GEHGFIGCRK399 VTGTLDANRS409 SYDVFQLEFN 419 DGAYNIKDST429 GKYWTVGSDS439 AVTSSGDTPV449 DFFFEFCDYN459 KVAIKVGGRY 469 LKGDHAGVLK479 ASAETVDPAS489 LWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H0B or .H0B2 or .H0B3 or :3H0B;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:50 or .A:56 or .A:57 or .A:58 or .A:60 or .A:62 or .A:93 or .A:101 or .A:102 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 2 | PDB:6I10 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
QIQFGLINCG
20 NKYLTAEAFG30 FKVNASASSL40 KKKQIWTLEQ50 PPDEAGSAAV60 CLRSHLGRYL 70 AADKDGNVTC80 EREVPGPDCR90 FLIVAHDDGR100 WSLQSEAHRR110 YFGGTEDRLS 120 CFAQTVSPAE130 KWSVHIAMHP140 QVNIYSVTRK150 RYAHLSARPA160 DEIAVDRDVP 170 WGVDSLITLA180 FQDQRYSVQT190 ADHRFLRHDG200 RLVARPEPAT210 GYTLEFRSGK 220 VAFRDCEGRY230 LAPSGPSGTL240 KAGKATKVGK250 DELFALEQSC260 AQVVLQAANE 270 RNVSTRQGMD280 LSANQDEETD290 QETFQLEIDR300 DTKKCAFRTH310 TGKYWTLTAT 320 GGVQSTASSK330 NASCYFDIEW340 RDRRITLRAS350 NGKFVTSKKN360 GQLAASVETA 370 GDSELFLMKL380 INRPIIVFRG390 EHGFIGCRKV400 TGTLDANRSS410 YDVFQLEFND 420 GAYNIKDSTG430 KYWTVGSDSA440 VTSSGDTPVD450 FFFEFCDYNK460 VAIKVGGRYL 470 KGDHAGVLKA480 SAETVDPASL490 WEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GZK or .GZK2 or .GZK3 or :3GZK;style chemicals stick;color identity;select .A:14 or .A:16 or .A:48 or .A:58 or .A:60 or .A:62 or .A:93 or .A:101 or .A:102 or .A:103 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide | Ligand Info | |||||
| Structure Description | Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule | PDB:6B0T | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
AEAVQIQFGL
16 INCGNKYLTA26 EAFGFKVNAS36 ASSLKKKQIW46 TLEQPPDEAG56 SAAVCLRSHL 66 GRYLAADKDG76 NVTCEREVPG86 PDCRFLIVAH96 DDGRWSLQSE106 AHRRYFGGTE 116 DRLSCFAQTV126 SPAEKWSVHI136 AMHPQVNIYS146 VTRKRYAHLS156 ARPADEIAVD 166 RDVPWGVDSL176 ITLAFQDQRY186 SVQTADHRFL196 RHDGRLVARP206 EPATGYTLEF 216 RSGKVAFRDC226 EGRYLAPSGP236 SGTLKAGKAT246 KVGKDELFAL256 EQSCAQVVLQ 266 AANERNVSTR276 QGMDLSANQD286 EETDQETFQL296 EIDRDTKKCA306 FRTHTGKYWT 316 LTATGGVQST326 ASSKNASCYF336 DIEWRDRRIT346 LRASNGKFVT356 SKKNGQLAAS 366 VETAGDSELF376 LMKLINRPII386 VFRGEHGFIG396 CRKVTGTLDA406 NRSSYDVFQL 416 EFNDGAYNIK426 DSTGKYWTVG436 SDSAVTSSGD446 TPVDFFFEFC456 DYNKVAIKVG 466 GRYLKGDHAG476 VLKASAETVD486 PASLWEY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .C7V or .C7V2 or .C7V3 or :3C7V;style chemicals stick;color identity;select .A:11 or .A:14 or .A:16 or .A:48 or .A:49 or .A:50 or .A:60 or .A:62 or .A:93 or .A:95 or .A:101 or .A:102 or .A:103 or .A:132 or .A:134 or .A:214 or .A:215 or .A:216 or .A:217 or .A:218 or .A:219; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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GLN11
3.781
PHE14
2.429
LEU16
2.455
LEU48
2.238
GLU49
4.127
GLN50
1.758
VAL60
3.406
LEU62
2.745
ILE93
3.040
ALA95
4.530
TRP101
2.660
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg Med Chem Lett. 2019 Apr 15;29(8):1023-1029. | ||||
| REF 2 | Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor. J Mol Biol. 2018 Apr 27;430(9):1324-1335. | ||||
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