Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68547 | Target Info | |||
| Target Name | Histone deacetylase 1 (HDAC1) | ||||
| Synonyms | RPD3L1; HD1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | HDAC1 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Myo-inositol hexaphosphate | Ligand Info | |||||
| Structure Description | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | PDB:5ICN | ||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
RRKVCYYYDG
17 DVGNYYYGQG27 HPMKPHRIRM37 THNLLLNYGL47 YRKMEIYRPH57 KANAEEMTKY 67 HSDDYIKFLR77 SIRPDNMSEY87 SKQMQRFNVG97 EDCPVFDGLF107 EFCQLSTGGS 117 VASAVKLNKQ127 QTDIAVNWAG137 GLHHAKKSEA147 SGFCYVNDIV157 LAILELLKYH 167 QRVLYIDIDI177 HHGDGVEEAF187 YTTDRVMTVS197 FHKYGEYFPG207 TGDLRDIGAG 217 KGKYYAVNYP227 LRDGIDDESY237 EAIFKPVMSK247 VMEMFQPSAV257 VLQCGSDSLS 267 GDRLGCFNLT277 IKGHAKCVEF287 VKSFNLPMLM297 LGGGGYTIRN307 VARCWTYETA 317 VALDTEIPNE327 LPYNDYFEYF337 GPDFKLHISP347 SNMTNQNTNE357 YLEKIKQRLF 367 ENLRMLPHA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2S)-2-amino-8-(hydroxyamino)-8-oxooctanoic acid | Ligand Info | |||||
| Structure Description | HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | PDB:5ICN | ||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
RRKVCYYYDG
17 DVGNYYYGQG27 HPMKPHRIRM37 THNLLLNYGL47 YRKMEIYRPH57 KANAEEMTKY 67 HSDDYIKFLR77 SIRPDNMSEY87 SKQMQRFNVG97 EDCPVFDGLF107 EFCQLSTGGS 117 VASAVKLNKQ127 QTDIAVNWAG137 GLHHAKKSEA147 SGFCYVNDIV157 LAILELLKYH 167 QRVLYIDIDI177 HHGDGVEEAF187 YTTDRVMTVS197 FHKYGEYFPG207 TGDLRDIGAG 217 KGKYYAVNYP227 LRDGIDDESY237 EAIFKPVMSK247 VMEMFQPSAV257 VLQCGSDSLS 267 GDRLGCFNLT277 IKGHAKCVEF287 VKSFNLPMLM297 LGGGGYTIRN307 VARCWTYETA 317 VALDTEIPNE327 LPYNDYFEYF337 GPDFKLHISP347 SNMTNQNTNE357 YLEKIKQRLF 367 ENLRMLPHA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nat Commun. 2016 Apr 25;7:11262. | ||||
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