Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T72319 Target Info
Target Name Chromobox protein homolog 7 (CBX7)
Synonyms Chromobox 7
Target Type Literature-reported Target
Gene Name CBX7
UniProt ID
CBX7_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N-Trimethyllysine Ligand Info
Structure Description Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7) PDB:4MN3
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
GEQVFAVESI
10
RKKRVRKGKV
20
EYLVKWKGWP
30
PKYSTWEPEE
40
HILDPRLVMA
50

YEEKEE
Residue
Distance (Å)
GLU2
3.611
GLN3
2.986
PHE5
3.469
TRP26
3.677
TRP29
3.559
Residue
Distance (Å)
TYR33
3.373
THR35
4.331
GLU37
3.524
HIS41
4.402
Ligand Name: 3,6,9,12,15,18-Hexaoxaicosane-1,20-diol Ligand Info
Structure Description Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7) PDB:4MN3
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
GEQVFAVESI
10
RKKRVRKGKV
20
EYLVKWKGWP
30
PKYSTWEPEE
40
HILDPRLVMA
50

YEEKEE
Residue
Distance (Å)
LYS13
2.804
VAL15
3.605
VAL20
3.960
TYR22
4.973
Residue
Distance (Å)
TYR51
4.953
GLU52
3.993
GLU55
3.062
References  Top
REF 1 Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem. 2014 Apr 10;57(7):2874-83.

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