Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74483 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv7.2 (KCNQ2) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel alpha subunit KvLQT2; Neuroblastoma-specific potassium channel KQT-like 2; KQT-like 2; KCNQ2; K+ channel KCNQ2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KCNQ2 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Retigabine | Ligand Info | |||||
| Structure Description | human KCNQ2 in complex with retigabine | PDB:7CR2 | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
RNAFYRKLQN
79 FLYNVLERPR89 GWAFIYHAYV99 FLLVFSCLVL109 SVFSTIKEYE119 KSSEGALYIL 129 EIVTIVVFGV139 EYFVRIWAAG149 CCCRYRGWRG159 RLKFARKPFC169 VIDIMVLIAS 179 IAVLASALRS199 LRFLQILRMI209 RMDRRGGTWK219 LLGSVVYAHS229 KELVTAWYIG 239 FLCLILASFL249 VYLAEKGEND259 HFDTYADALW269 WGLITLTTIG279 YGDKYPQTWN 289 GRLLAATFTL299 IGVSFFALPA309 GILGSGFALK319 VQEQHRQKHF329 E |
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| Ligand Name: ZTZ240 | Ligand Info | |||||
| Structure Description | human KCNQ2 in complex with ztz240 | PDB:7CR1 | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
RNAFYRKLQN
79 FLYNVLERPR89 GWAFIYHAYV99 FLLVFSCLVL109 SVFSTIKEYE119 KSSEGALYIL 129 EIVTIVVFGV139 EYFVRIWAAG149 CCCRYRGWRG159 RLKFARKPFC169 VIDIMVLIAS 179 IAVLASALRS199 LRFLQILRMI209 RMDRRGGTWK219 LLGSVVYAHS229 KELVTAWYIG 239 FLCLILASFL249 VYLAEKGEND259 HFDTYADALW269 WGLITLTTIG279 YGDKYPQTWN 289 GRLLAATFTL299 IGVSFFALPA309 GILGSGFALK319 VQEQHRQKHF329 |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res. 2021 Jan;31(1):52-61. | ||||
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