Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79798 | Target Info | |||
| Target Name | MAP kinase p38 (MAPK12) | ||||
| Synonyms | Stress-activated protein kinase 3; SAPK3; Mitogen-activated proteinkinase p38 gamma; Mitogen-activated proteinkinase 12; MAPK12; Extracellular signal-regulated kinase 6; ERK6; ERK5; ERK-6 | ||||
| Target Type | Successful Target | ||||
| Gene Name | MAPK12 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | PHOSPHORYLATED MAP KINASE P38-GAMMA | PDB:1CM8 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
RSGFYRQEVT
17 KTAWEVRAVY27 RDLQPVAVCS43 AVDGRTGAKV53 AIKKLYRPFQ63 SELFAKRAYR 73 ELRLLKHMRH83 ENVIGLLDVF93 TPDETLDDFT103 DFYLVMPFMG113 TDLGKLMKHE 123 KLGEDRIQFL133 VYQMLKGLRY143 IHAAGIIHRD153 LKPGNLAVNE163 DCELKILDFG 173 LARQADSEMG184 VVTRWYRAPE195 VILNWMRYTQ205 TVDIWSVGCI215 MAEMITGKTL 225 FKGSDHLDQL235 KEIMKVTGTP245 PAEFVQRLQS255 DEAKNYMKGL265 PELEKKDFAS 275 ILTNASPLAV285 NLLEKMLVLD295 AEQRVTAGEA305 LAHPYFESLH315 QVQKYDDSRT 336 LDEWKRVTYK346 EVLSFKP
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VAL33
4.020
ALA40
3.871
VAL41
3.537
ALA54
3.387
LYS56
2.934
ILE87
3.574
MET109
2.905
PRO110
2.797
PHE111
3.711
MET112
2.858
GLY113
4.222
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | PHOSPHORYLATED MAP KINASE P38-GAMMA | PDB:1CM8 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
RSGFYRQEVT
17 KTAWEVRAVY27 RDLQPVAVCS43 AVDGRTGAKV53 AIKKLYRPFQ63 SELFAKRAYR 73 ELRLLKHMRH83 ENVIGLLDVF93 TPDETLDDFT103 DFYLVMPFMG113 TDLGKLMKHE 123 KLGEDRIQFL133 VYQMLKGLRY143 IHAAGIIHRD153 LKPGNLAVNE163 DCELKILDFG 173 LARQADSEMG184 VVTRWYRAPE195 VILNWMRYTQ205 TVDIWSVGCI215 MAEMITGKTL 225 FKGSDHLDQL235 KEIMKVTGTP245 PAEFVQRLQS255 DEAKNYMKGL265 PELEKKDFAS 275 ILTNASPLAV285 NLLEKMLVLD295 AEQRVTAGEA305 LAHPYFESLH315 QVQKYDDSRT 336 LDEWKRVTYK346 EVLSFKP
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| Ligand Name: Phosphonotyrosine | Ligand Info | |||||
| Structure Description | PHOSPHORYLATED MAP KINASE P38-GAMMA | PDB:1CM8 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
RSGFYRQEVT
17 KTAWEVRAVY27 RDLQPVAVCS43 AVDGRTGAKV53 AIKKLYRPFQ63 SELFAKRAYR 73 ELRLLKHMRH83 ENVIGLLDVF93 TPDETLDDFT103 DFYLVMPFMG113 TDLGKLMKHE 123 KLGEDRIQFL133 VYQMLKGLRY143 IHAAGIIHRD153 LKPGNLAVNE163 DCELKILDFG 173 LARQADSEMG184 VVTRWYRAPE195 VILNWMRYTQ205 TVDIWSVGCI215 MAEMITGKTL 225 FKGSDHLDQL235 KEIMKVTGTP245 PAEFVQRLQS255 DEAKNYMKGL265 PELEKKDFAS 275 ILTNASPLAV285 NLLEKMLVLD295 AEQRVTAGEA305 LAHPYFESLH315 QVQKYDDSRT 336 LDEWKRVTYK346 EVLSFKP
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation. Structure. 1999 Sep 15;7(9):1057-65. | ||||
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