Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T82078 Target Info
Target Name Toll-like receptor 2 (TLR2)
Synonyms Toll/interleukin-1 receptor-like protein 4; TIL4; CD282
Target Type Clinical trial Target
Gene Name TLR2
Biochemical Class Toll-like receptor
UniProt ID
TLR2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2r)-3-{[(2s)-3-Hydroxy-2-(Palmitoylamino)propyl]thio}propane-1,2-Diyl Dihexadecanoate Ligand Info
Structure Description Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide PDB:2Z7X
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
SLSCDRNGIC
36
KGSSGSLNSI
46
PSGLTEAVKS
56
LDLSNNRITY
66
ISNSDLQRCV
76

NLQALVLTSN
86
GINTIEEDSF
96
SSLGSLEHLD
106
LSYNYLSNLS
116
SSWFKPLSSL
126

TFLNLLGNPY
136
KTLGETSLFS
146
HLTKLQILRV
156
GNMDTFTKIQ
166
RKDFAGLTFL
176

EELEIDASDL
186
QSYEPKSLKS
196
IQNVSHLILH
206
MKQHILLLEI
216
FVDVTSSVEC
226

LELRDTDLDT
236
FHFSELSTGE
246
TNSLIKKFTF
256
RNVKITDESL
266
FQVMKLLNQI
276

SGLLELEFDD
286
CTLNGVGNFR
296
ASDNDRVIDP
306
GKVETLTIRR
316
LHIPRFYLFY
326

DLSTLYSLTE
336
RVKRITVENS
346
KVFLVPCLLS
356
QHLKSLEYLD
366
LSENLMVEEY
376

LKNSACEDAW
386
PSLQTLILRQ
396
NHLASLEKTG
406
ETLLTLKNLT
416
NIDISKNSFH
426

SMPETCQWPE
436
KMKYLNLSST
446
RIHSVTGCIP
456
KTLEILDVSN
466
NNLNLFSLNL
476

PQLKELYISR
486
NKLMTLPDAS
496
LLPMLLVLKI
506
SRNQLKSVPD
516
GIFDRLTSLQ
526

KIWLHTNPWD
536
CSCPRIDYLS
546
RWLNKNSQKE
556
QGSAKCSGSG
566
KPVRSIICP
Residue
Distance (Å)
LEU266
4.205
MET270
3.639
LEU273
4.270
LEU282
3.388
PHE284
4.057
PHE295
4.566
ASP305
4.774
PRO306
4.103
VAL309
4.005
LEU312
3.694
ILE314
4.329
LEU317
3.893
ILE319
3.901
PHE322
3.672
TYR323
4.590
PHE325
3.580
TYR326
3.672
ASP327
3.503
Residue
Distance (Å)
LEU328
3.672
LEU331
4.212
LEU334
3.178
THR335
4.487
VAL338
4.104
ILE341
4.108
VAL343
4.053
SER346
3.500
LYS347
3.380
VAL348
3.584
PHE349
3.076
LEU350
2.977
VAL351
3.650
PRO352
3.308
LEU355
3.723
LEU359
4.838
TYR376
3.747
References  Top
REF 1 Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007 Sep 21;130(6):1071-82.

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