Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83797 | Target Info | |||
| Target Name | Hepatocyte growth factor (HGF) | ||||
| Synonyms | Scatter factor; SF; Hepatopoietin-A; Hepatopoeitin A; HPTA | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | HGF | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N,O6-Disulfo-Glucosamine | Ligand Info | |||||
| Structure Description | Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin | PDB:3MKP | ||||
| Method | X-ray diffraction | Resolution | 2.81 Å | Mutation | Yes | [1] |
| PDB Sequence |
RNTIHEFKKS
45 AKTTLIKIDP55 ALKIKTKKVN65 TADQCANRCT75 RNKGLPFTCK85 AFVFDKARKQ 95 CLWFPFNSMS105 SGVKKEFGHE115 FDLYENKDYI125 RNCIIGEGES135 YKGTVSITKS 145 GIKCQPWSSM155 IPHEHSFLPS165 SYRGKDLQEN175 YCRNPRGEEG185 GPWCFTSNPE 195 VRYEVCDIPQ205 CSE
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| Ligand Name: 3[N-Morpholino]propane sulfonic acid | Ligand Info | |||||
| Structure Description | The structure of the NK1 fragment of HGF/SF complexed with MOPS | PDB:5CSQ | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | Yes | [2] |
| PDB Sequence |
TIHEFKKSAK
47 TTLIKIDPAL57 KIKTKKVNTA67 DQCANRCTRN77 KGLPFTCKAF87 VFDKARKQCL 97 WFPFNSMSSG107 VKKEFGHEFD117 LYENKDYIRN127 CIIGKGRSYK137 GTVSITKSGI 147 KCQPWSSMIP157 HEHSFLPSSY167 RGKDLQENYC177 RNPRGEEGGP187 WCFTSNPEVR 197 YEVCDIPQCS207 EVE
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| Ligand Name: 3-Cyclohexyl-1-propylsulfonic acid | Ligand Info | |||||
| Structure Description | The structure of the NK1 fragment of HGF/SF complexed with CAPS | PDB:5CT2 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
TIHEFKKSAK
47 TTLIKIDPAL57 KIKTKKVNTA67 DQCANRCTRN77 KGLPFTCKAF87 VFDKARKQCL 97 WFPFNSMSSG107 VKKEFGHEFD117 LYENKDYIRN127 CIIGKGRSYK137 GTVSITKSGI 147 KCQPWSSMIP157 HEHSFLPSSY167 RGKDLQENYC177 RNPRGEEGGP187 WCFTSNPEVR 197 YEVCDIPQCS207 EVE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration | ||||
| REF 2 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci. 2015 Nov 1;6(11):6147-6157. | ||||
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