Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84486 | Target Info | |||
| Target Name | Oxytocin receptor (OTR) | ||||
| Synonyms | OT-R | ||||
| Target Type | Successful Target | ||||
| Gene Name | OXTR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Retosiban | Ligand Info | |||||
| Structure Description | Crystal structure of the human oxytocin receptor | PDB:6TPK | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
NEALARVEVA
44 VLCLILLLAL54 SGNACVLLAL64 HHSRLFFFMK79 HLSIADLVVA89 VFQVLPQLLW 99 DITFRFYGPD109 LLCRLVKYLQ119 LVGMFASTYL129 LLLMSLDRCL139 AICQPLRSLR 149 RRTARLAVLA159 TWLGCLVVSA169 PQVHIFSLRE179 VADGVFDCWA189 VFIRPWGPKA 199 YITWITLAVY209 IVPVIVLATC219 YGLIAFKIWQ229 NLISKAKIRT273 VKMTFIIVLA 283 FIVCWTPFFF293 VQMWSVWDAN303 APKEASAFII313 VMLLASLNCC323 CKPWIYMLFM 333 GHLFHGIDSF344 WNESYLTGSR356 DERKKSLLSK366 FGMDEGVTFM376 FIGRFDRGQK 386 GVDVLLKAIE396 ILSSKKEFQE406 MRFIIIGKGD416 PELEGWARSL426 EEKHGNVKVI 436 TEMLSREFVR446 ELYGSVDFVI456 IPSYFEPFGL466 VALEAMCLGA476 IPIASAVGGL 486 RDIITNETGI496 LVKAGDPGEL506 ANAILKALEL516 SRSDLSKFRE526 NCKKRAMSFS 536
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VAL88
4.251
GLN92
3.250
GLN96
4.382
LYS116
3.423
GLN119
3.458
LEU120
4.814
MET123
3.603
GLN171
2.439
PHE175
3.768
TRP188
4.934
PHE191
4.971
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Crystal structure of the human oxytocin receptor | PDB:6TPK | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
NEALARVEVA
44 VLCLILLLAL54 SGNACVLLAL64 HHSRLFFFMK79 HLSIADLVVA89 VFQVLPQLLW 99 DITFRFYGPD109 LLCRLVKYLQ119 LVGMFASTYL129 LLLMSLDRCL139 AICQPLRSLR 149 RRTARLAVLA159 TWLGCLVVSA169 PQVHIFSLRE179 VADGVFDCWA189 VFIRPWGPKA 199 YITWITLAVY209 IVPVIVLATC219 YGLIAFKIWQ229 NLISKAKIRT273 VKMTFIIVLA 283 FIVCWTPFFF293 VQMWSVWDAN303 APKEASAFII313 VMLLASLNCC323 CKPWIYMLFM 333 GHLFHGIDSF344 WNESYLTGSR356 DERKKSLLSK366 FGMDEGVTFM376 FIGRFDRGQK 386 GVDVLLKAIE396 ILSSKKEFQE406 MRFIIIGKGD416 PELEGWARSL426 EEKHGNVKVI 436 TEMLSREFVR446 ELYGSVDFVI456 IPSYFEPFGL466 VALEAMCLGA476 IPIASAVGGL 486 RDIITNETGI496 LVKAGDPGEL506 ANAILKALEL516 SRSDLSKFRE526 NCKKRAMSFS 536
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| Ligand Name: Cysteine-S-Acetamide | Ligand Info | |||||
| Structure Description | Crystal structure of the human oxytocin receptor | PDB:6TPK | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
NEALARVEVA
44 VLCLILLLAL54 SGNACVLLAL64 HHSRLFFFMK79 HLSIADLVVA89 VFQVLPQLLW 99 DITFRFYGPD109 LLCRLVKYLQ119 LVGMFASTYL129 LLLMSLDRCL139 AICQPLRSLR 149 RRTARLAVLA159 TWLGCLVVSA169 PQVHIFSLRE179 VADGVFDCWA189 VFIRPWGPKA 199 YITWITLAVY209 IVPVIVLATC219 YGLIAFKIWQ229 NLISKAKIRT273 VKMTFIIVLA 283 FIVCWTPFFF293 VQMWSVWDAN303 APKEASAFII313 VMLLASLNCC323 CKPWIYMLFM 333 GHLFHGIDSF344 WNESYLTGSR356 DERKKSLLSK366 FGMDEGVTFM376 FIGRFDRGQK 386 GVDVLLKAIE396 ILSSKKEFQE406 MRFIIIGKGD416 PELEGWARSL426 EEKHGNVKVI 436 TEMLSREFVR446 ELYGSVDFVI456 IPSYFEPFGL466 VALEAMCLGA476 IPIASAVGGL 486 RDIITNETGI496 LVKAGDPGEL506 ANAILKALEL516 SRSDLSKFRE526 NCKKRAMSFS 536
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the human oxytocin receptor. Sci Adv. 2020 Jul 15;6(29):eabb5419. | ||||
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