Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T93904 Target Info
Target Name Phosphatidylethanolamine-binding protein 1 (PEBP1)
Synonyms Raf kinase inhibitor protein; RKIP; Prostatic-binding protein; PEBP-1; PEBP; PBP; Neuropolypeptide h3; Hippocampal cholinergic neurostimulating peptide; HCNPpp; HCNP
Target Type Literature-reported Target
Gene Name PEBP1
Biochemical Class Phosphatidylethanolamine-binding protein family
UniProt ID
PEBP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Phosphonotyrosine Ligand Info
Structure Description Human raf kinase inhibitor protein (rkip) in complex with o-phosphotyrosine PDB:2QYQ
Method X-ray diffraction Resolution 1.95 Å Mutation No [1]
PDB Sequence
MPVDLSKWSG
10
PLSLQEVDEQ
20
PQHPLHVTYA
30
GAAVDELGKV
40
LTPTQVKNRP
50

TSISWDGLDS
60
GKLYTLVLTD
70
PDAPSRKDPK
80
YREWHHFLVV
90
NMKGNDISSG
100

TVLSDYVGSG
110
PPKGTGLHRY
120
VWLVYEQDRP
130
LKCDEPILSN
140
RSGDHRGKFK
150

VASFRKKYEL
160
RAPVAGTCYQ
170
AEWDDYVPKL
180
YEQLSG
Residue
Distance (Å)
ASP70
2.498
ALA73
4.446
TRP84
3.145
HIS86
2.641
GLY108
4.628
SER109
3.649
GLY110
2.710
Residue
Distance (Å)
PRO111
3.338
PRO112
3.888
HIS118
3.355
TYR120
2.525
TYR181
3.563
LEU184
3.661
References  Top
REF 1 Phosphotyrosine recognition by the Raf Kinase Inhibitor Protein

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