Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T94048 Target Info
Target Name Yes-associated protein 1 (YAP1)
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Target Type Literature-reported Target
Gene Name YAP1
UniProt ID
YAP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Octane Ligand Info
Structure Description YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2 PDB:1K9Q
Method Solution NMR Resolution N.A. Mutation Yes [1]
PDB Sequence
FEIPDDVPLP
14
AGWEMAKTSS
24
GQRYFLNHID
34
QTTTWQDPRK
44
Residue
Distance (Å)
TRP39
4.646
Residue
Distance (Å)
References  Top
REF 1 Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. J Mol Biol. 2001 Dec 14;314(5):1147-56.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.