Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94621 | Target Info | |||
| Target Name | RAC-beta serine/threonine-protein kinase (AKT2) | ||||
| Synonyms | RAC-PK-beta; Protein kinase B beta; Protein kinase Akt-2; PKB beta | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | AKT2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: GSK690693 | Ligand Info | |||||
| Structure Description | Crystal structure of human Akt2 in complex with GSK690693 | PDB:3D0E | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITIPPDQRT 468 HFPQFDYSAS478 IR
|
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|
|
LEU158
3.786
GLY159
3.902
LYS160
3.806
PHE163
3.889
VAL166
3.427
ALA179
3.654
LYS181
3.401
GLU200
2.650
LEU204
3.464
THR213
4.112
LEU215
4.585
PHE227
3.627
MET229
3.404
|
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| Ligand Name: A-443654 | Ligand Info | |||||
| Structure Description | STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654 | PDB:2JDR | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
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| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide | PDB:1O6L | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [3] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ANP or .ANP2 or .ANP3 or :3ANP;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:163 or .A:164 or .A:166 or .A:179 or .A:181 or .A:200 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:275 or .A:277 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.925
GLY159
3.697
LYS160
4.762
GLY161
4.478
PHE163
4.877
GLY164
4.415
VAL166
3.357
ALA179
3.490
LYS181
2.830
GLU200
4.958
THR213
3.636
MET229
3.482
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide | PDB:1O6L | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [3] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TPO or .TPO2 or .TPO3 or :3TPO;style chemicals stick;color identity;select .A:196 or .A:274 or .A:298 or .A:307 or .A:308 or .A:310 or .A:311 or .A:321 or .A:327; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino)ethyl)amide | Ligand Info | |||||
| Structure Description | STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE | PDB:2JDO | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITMFEDFDY 475 IADW
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .I5S or .I5S2 or .I5S3 or :3I5S;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.772
GLY159
3.734
LYS160
3.256
GLY161
3.416
PHE163
4.900
GLY164
3.144
LYS165
3.316
VAL166
3.384
ALA179
3.432
LYS181
3.597
THR213
3.964
|
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| Ligand Name: 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide | Ligand Info | |||||
| Structure Description | Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB | PDB:2X39 | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [4] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .X39 or .X392 or .X393 or :3X39;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:182 or .A:183 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.945
GLY159
3.588
LYS160
3.728
GLY161
3.439
PHE163
4.202
GLY164
3.545
LYS165
3.982
VAL166
3.661
ALA179
3.291
LYS181
3.393
ILE182
4.908
LEU183
3.477
|
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| Ligand Name: 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine | Ligand Info | |||||
| Structure Description | STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine | PDB:2UW9 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [5] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GVP or .GVP2 or .GVP3 or :3GVP;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:162 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:183 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.904
GLY159
3.661
LYS160
3.689
GLY161
3.459
THR162
4.901
PHE163
4.426
GLY164
3.206
LYS165
3.495
VAL166
3.162
ALA179
3.066
LYS181
3.521
LEU183
3.718
|
|||||
| Ligand Name: 4-(4-tert-butylbenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium | Ligand Info | |||||
| Structure Description | Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB | PDB:2XH5 | ||||
| Method | X-ray diffraction | Resolution | 2.72 Å | Mutation | Yes | [4] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITQEMFEDF 473 DYIADW
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .X37 or .X372 or .X373 or :3X37;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:162 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:182 or .A:183 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.629
GLY159
3.387
LYS160
3.259
GLY161
2.921
THR162
4.506
PHE163
3.710
GLY164
2.806
LYS165
3.550
VAL166
2.734
ALA179
3.465
LYS181
3.002
ILE182
4.329
LEU183
3.592
|
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| Ligand Name: N-[(1s)-2-Amino-1-Phenylethyl]-5-(1h-Pyrrolo[2,3-B]pyridin-4-Yl)thiophene-2-Carboxamide | Ligand Info | |||||
| Structure Description | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | PDB:3E87 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [6] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITIPPQRTH 469 FPQFDYSASI479 R
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G95 or .G952 or .G953 or :3G95;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:183 or .A:213 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:439; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.759
GLY159
4.449
LYS160
3.894
GLY161
3.756
PHE163
4.310
GLY164
3.407
LYS165
3.662
VAL166
3.684
ALA179
3.395
LYS181
3.526
LEU183
3.732
THR213
3.446
|
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| Ligand Name: 4-[2-(4-Amino-1,2,5-Oxadiazol-3-Yl)-6-{[(2r)-2-Amino-3-Phenylpropyl]oxy}-1-Ethyl-1h-Imidazo[4,5-C]pyridin-4-Yl]-2-Methylbut-3-Yn-2-Ol | Ligand Info | |||||
| Structure Description | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | PDB:3E88 | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | Yes | [6] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITIQRTHFP 471 QFDYSASIR
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G96 or .G962 or .G963 or :3G96;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:163 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:183 or .A:200 or .A:204 or .A:213 or .A:227 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:277 or .A:280 or .A:282 or .A:292 or .A:293 or .A:294 or .A:439; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.821
GLY159
3.545
LYS160
4.096
GLY161
3.665
PHE163
3.967
GLY164
3.369
LYS165
3.428
VAL166
3.577
ALA179
3.344
LYS181
3.666
LEU183
3.570
GLU200
2.872
LEU204
3.812
THR213
4.015
|
|||||
| Ligand Name: 4-[(2Z)-2-(4-amino-1,2,5-oxadiazol-3-ylidene)-6-[(1S)-3-amino-1-phenylpropoxy]-1-ethyl-3H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | Ligand Info | |||||
| Structure Description | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | PDB:3E8D | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [6] |
| PDB Sequence |
KVTMNDFDYL
155 KLLGKGTFGK165 VILVREKATG175 RYYAMKILRK185 EVIIAKDEVA195 HTVTESRVLQ 205 NTRHPFLTAL215 KYAFQTHDRL225 CFVMEYANGG235 ELFFHLSRER245 VFTEERARFY 255 GAEIVSALEY265 LHSRDVVYRD275 IKLENLMLDK285 DGHIKITDFG295 LCKEGISDGA 305 TMKFCGTPEY316 LAPEVLEDND326 YGRAVDWWGL336 GVVMYEMMCG346 RLPFYNQDHE 356 RLFELILMEE366 IRFPRTLSPE376 AKSLLAGLLK386 KDPKQRLGGG396 PSDAKEVMEH 406 RFFLSINWQD416 VVQKKLLPPF426 KPQVTSEVDT436 RYFDDEFTAQ446 SITHFPQFDY 475 SASIR
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G98 or .G982 or .G983 or :3G98;style chemicals stick;color identity;select .A:158 or .A:159 or .A:160 or .A:161 or .A:164 or .A:165 or .A:166 or .A:179 or .A:181 or .A:183 or .A:200 or .A:204 or .A:213 or .A:215 or .A:227 or .A:229 or .A:230 or .A:231 or .A:232 or .A:236 or .A:275 or .A:277 or .A:279 or .A:280 or .A:282 or .A:292 or .A:293 or .A:294 or .A:439; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU158
3.764
GLY159
3.730
LYS160
3.676
GLY161
3.598
GLY164
3.544
LYS165
3.696
VAL166
3.356
ALA179
3.284
LYS181
3.481
LEU183
4.616
GLU200
2.522
LEU204
3.533
THR213
3.857
LEU215
4.693
PHE227
3.526
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-o... J Med Chem. 2008 Sep 25;51(18):5663-79. | ||||
| REF 2 | A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. J Mol Biol. 2007 Mar 30;367(3):882-94. | ||||
| REF 3 | Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol. 2002 Dec;9(12):940-4. | ||||
| REF 4 | Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt). J Med Chem. 2010 Mar 11;53(5):2239-49. | ||||
| REF 5 | Identification of inhibitors of protein kinase B using fragment-based lead discovery. J Med Chem. 2007 May 17;50(10):2293-6. | ||||
| REF 6 | Aminofurazans as potent inhibitors of AKT kinase. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1508-11. | ||||
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