Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95446 | Target Info | |||
| Target Name | Cytochrome P450 reductase (P450) | ||||
| Synonyms | P450R; NADPH--cytochrome P450 reductase; CYPOR; CPR | ||||
| Target Type | Discontinued Target | ||||
| Gene Name | POR | ||||
| Biochemical Class | NADH/NADPH oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: flavin mononucleotide | Ligand Info | |||||
| Structure Description | Crystal Structure of Human NADPH-Cytochrome P450 Reductase | PDB:3QE2 | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
ESSFVEKMKK
78 TGRNIIVFYG88 SQTGTAEEFA98 NRLSKDAHRY108 GMRGMSADPE118 EYDLADLSSL 128 PEIDNALVVF138 CMATYGEGDP148 TDNAQDFYDW158 LQETDVDLSG168 VKFAVFGLGN 178 KTYEHFNAMG188 KYVDKRLEQL198 GAQRIFELGL208 GDDDGNLEED218 FITWREQFWL 228 AVCEHFGVEA238 TSSIRQYELV251 VHTDIDAAKV261 YMGEMGRLKS271 YENQKPPFDA 281 KNPFLAAVTT291 NRKLNQGTER301 HLMHLELDIS311 DSKIRYESGD321 HVAVYPANDS 331 ALVNQLGKIL341 GADLDVVMSL351 NNLDEESNKK361 HPFPCPTSYR371 TALTYYLDIT 381 NPPRTNVLYE391 LAQYASEPSE401 QELLRKMASS411 SGEGKELYLS421 WVVEARRHIL 431 AILQDCPSLR441 PPIDHLCELL451 PRLQARYYSI461 ASSSKVHPNS471 VHICAVVVEY 481 ETKAGRINKG491 VATNWLRAKE501 PVRALVPMFV516 RKSQFRLPFK526 ATTPVIMVGP 536 GTGVAPFIGF546 IQERAWLRQQ556 GKEVGETLLY566 YGCRRSDEDY576 LYREELAQFH 586 RDGALTQLNV596 AFSREQSHKV606 YVQHLLKQDR616 EHLWKLIEGG626 AHIYVCGDAR 636 NMARDVQNTF646 YDIVAELGAM656 EHAQAVDYIK666 KLMTKGRYSL676 DVWS |
|||||
|
|
GLY88
4.304
SER89
2.521
GLN90
2.678
THR91
2.548
GLY92
3.514
THR93
2.671
ALA94
2.782
GLU95
4.647
ALA141
3.319
THR142
2.635
TYR143
2.673
GLY144
3.660
GLU145
4.127
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Flavin-Adenine Dinucleotide | Ligand Info | |||||
| Structure Description | Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain) | PDB:3QFS | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
| PDB Sequence |
RQYELVVHTD
255 IDAAKVYMGE265 MGRLKSYENQ275 KPPFDAKNPF285 LAAVTTNRKL295 NQGTERHLMH 305 LELDISDSKI315 RYESGDHVAV325 YPANDSALVN335 QLGKILGADL345 DVVMSLNNLD 355 EESNKKHPFP365 CPTSYRTALT375 YYLDITNPPR385 TNVLYELAQY395 ASEPSEQELL 405 RKMASSSGEG415 KELYLSWVVE425 ARRHILAILQ435 DCPSLRPPID445 HLCELLPRLQ 455 ARYYSIASSS465 KVHPNSVHIC475 AVVVEYETKA485 GRINKGVATN495 WLRAKEPVGE 505 NGGRALVPMF515 VRKSQFRLPF525 KATTPVIMVG535 PGTGVAPFIG545 FIQERAWLRQ 555 QGKEVGETLL565 YYGCRRSDED575 YLYREELAQF585 HRDGALTQLN595 VAFSREQSHK 605 VYVQHLLKQD615 REHLWKLIEG625 GAHIYVCGDA635 RNMARDVQNT645 FYDIVAELGA 655 MEHAQAVDYI665 KKLMTKGRYS675 LDVWS
|
|||||
|
|
HIS322
3.476
THR381
4.505
ASN382
4.568
ARG427
3.103
ARG457
2.774
TYR458
2.630
TYR459
2.757
SER460
3.075
CYS475
2.993
ALA476
3.125
VAL477
3.168
VAL479
3.663
TYR481
3.519
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: NADP+ | Ligand Info | |||||
| Structure Description | Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain) | PDB:3QFS | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
| PDB Sequence |
RQYELVVHTD
255 IDAAKVYMGE265 MGRLKSYENQ275 KPPFDAKNPF285 LAAVTTNRKL295 NQGTERHLMH 305 LELDISDSKI315 RYESGDHVAV325 YPANDSALVN335 QLGKILGADL345 DVVMSLNNLD 355 EESNKKHPFP365 CPTSYRTALT375 YYLDITNPPR385 TNVLYELAQY395 ASEPSEQELL 405 RKMASSSGEG415 KELYLSWVVE425 ARRHILAILQ435 DCPSLRPPID445 HLCELLPRLQ 455 ARYYSIASSS465 KVHPNSVHIC475 AVVVEYETKA485 GRINKGVATN495 WLRAKEPVGE 505 NGGRALVPMF515 VRKSQFRLPF525 KATTPVIMVG535 PGTGVAPFIG545 FIQERAWLRQ 555 QGKEVGETLL565 YYGCRRSDED575 YLYREELAQF585 HRDGALTQLN595 VAFSREQSHK 605 VYVQHLLKQD615 REHLWKLIEG625 GAHIYVCGDA635 RNMARDVQNT645 FYDIVAELGA 655 MEHAQAVDYI665 KKLMTKGRYS675 LDVWS
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NAP or .NAP2 or .NAP3 or :3NAP;style chemicals stick;color identity;select .A:301 or .A:303 or .A:477 or .A:536 or .A:537 or .A:538 or .A:568 or .A:569 or .A:570 or .A:575 or .A:597 or .A:599 or .A:600 or .A:605 or .A:607 or .A:608 or .A:609 or .A:637 or .A:638 or .A:641; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG301
2.629
LEU303
4.720
VAL477
4.196
PRO536
3.715
GLY537
3.560
THR538
3.017
GLY568
3.913
CYS569
3.055
ARG570
3.532
ASP575
4.365
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13486-91. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.