Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95742 | Target Info | |||
| Target Name | Neurofibromin-2 (NF2) | ||||
| Synonyms | Schwannomin; Schwannomerlin; SCH; Moesin-ezrin-radixin-like protein; Merlin | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NF2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [(2r)-2-Octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-Tris(Oxidanyl)-4,5-Diphosphonooxy-Cyclohexyl]oxy-Phosphoryl]oxy-Propyl] Octanoate | Ligand Info | |||||
| Structure Description | Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | PDB:6CDS | ||||
| Method | X-ray diffraction | Resolution | 2.62 Å | Mutation | Yes | [1] |
| PDB Sequence |
KRKQPKTFTV
24 RIVTMDAEME34 FNCEMKWKGK44 DLFDLVCRTL54 GLRETWFFGL64 QYTIKDTVAW 74 LKMDKKVLDH84 DVSKEEPVTF94 HFLAKFYPEN104 AEEELVQEIT114 QHLFFLQVKK 124 QILDEKIYCP134 PEASVLLASY144 AVQAKYGDYD154 PSVHKRGFLA164 QEELLPKRVI 174 NLYQMTPEMW184 EERITAWYAE194 HRGRARDEAE204 MEYLKIAQDL214 EMYGVNYFAI 224 RNKKGTELLL234 GVDALGLHIY244 DPENRLTPKI254 SFPWNEIRNI264 SYSDKEFTIK 274 PLDKKIDVFK284 FNSSKLRVNK294 LILQLCIENH304 DLFMRRRKAD314 SLEVQQMKAQ 324 AREEKARKQM334 ERQRL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2. Nat Commun. 2018 Apr 6;9(1):1338. | ||||
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