Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T95878 Target Info
Target Name Ribosomal protein S6 kinase alpha-6 (RSK6)
Synonyms pp90RSK4; p90RSK6; p90-RSK 6; S6K-alpha-6; Ribosomal S6 kinase 4; RSK4; RSK-4; 90 kDa ribosomal protein S6 kinase 6
Target Type Patented-recorded Target
Gene Name RPS6KA6
UniProt ID
KS6A6_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: AMP-PNP Ligand Info
Structure Description RSK4 N-terminal Kinase Domain in complex with AMP-PNP PDB:6G77
Method X-ray diffraction Resolution 2.50 Å Mutation No [1]
PDB Sequence
VVKEIPITHH
60
VKEGYEKADP
70
AQFELLKVLG
80
QGSFGKVFLV
90
RKKTGPDAGQ
100

LYAMKVLKKA
110
SLKVRDDILV
128
EVNHPFIVKL
138
HYAFQTEGKL
148
YLILDFLRGG
158

DVFTRLSKEV
168
LFTEEDVKFY
178
LAELALALDH
188
LHQLGIVYRD
198
LKPENILLDE
208

IGHIKLTDFG
218
LSKESVDQEK
228
KAYSFCGTVE
238
YMAPEVVNRR
248
GHSQSADWWS
258

YGVLMFEMLT
268
GTLPFQGKDR
278
NETMNMILKA
288
KLGMPQFLSA
298
EAQSLLRMLF
308

KRNPANRLGS
318
EGVEEIKRHL
328
FFANIDWDKL
338
YKREVQPPFK
348
P
Residue
Distance (Å)
VAL52
3.876
LEU79
3.718
GLY80
3.579
GLN81
3.749
GLY82
2.938
SER83
1.714
PHE84
2.640
GLY85
3.791
VAL87
3.277
ALA103
3.173
LYS105
2.664
LYS113
3.351
VAL114
4.147
ARG115
3.671
VAL136
4.210
LEU152
4.426
ASP153
2.642
PHE154
3.853
LEU155
3.154
ASP159
4.944
Residue
Distance (Å)
GLY193
3.048
ILE194
4.141
VAL195
3.846
ARG197
3.182
ASP198
4.307
LYS200
1.128
GLU202
3.650
ASN203
2.460
LEU205
3.505
THR215
3.016
ASP216
4.726
SER220
3.796
LYS221
2.728
PHE233
3.710
CYS234
3.498
GLY235
4.475
ARG247
3.240
GLY249
4.085
HIS250
3.092
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Phosphorylated RSK4 N-terminal Kinase Domain in complex with AMP-PNP PDB:6G76
Method X-ray diffraction Resolution 3.00 Å Mutation No [1]
PDB Sequence
VVKEIPITHH
60
VKEGYEKADP
70
AQFELLKVLG
80
QGSFGKVFLV
90
RKKTGPDAGQ
100

LYAMKVLKKA
110
SLKVRDDILV
128
EVNHPFIVKL
138
HYAFQTEGKL
148
YLILDFLRGG
158

DVFTRLSKEV
168
LFTEEDVKFY
178
LAELALALDH
188
LHQLGIVYRD
198
LKPENILLDE
208

IGHIKLTDFG
218
LSKESVDQEK
228
KAYFCGTVEY
239
MAPEVVNRRG
249
HSQSADWWSY
259

GVLMFEMLTG
269
TLPFQGKDRN
279
ETMNMILKAK
289
LGMPQFLSAE
299
AQSLLRMLFK
309

RNPANRLGSE
319
GVEEIKRHLF
329
FANIDWDKLY
339
KREVQPPFKP
349
Residue
Distance (Å)
SER83
3.263
PHE84
4.067
LYS228
2.932
LYS229
3.214
Residue
Distance (Å)
ALA230
3.524
TYR231
1.332
PHE233
1.329
CYS234
3.446
References  Top
REF 1 Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Sci Transl Med. 2021 Jul 14;13(602):eaba4627.

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