Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97149 | Target Info | |||
| Target Name | Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) | ||||
| Synonyms | Regulatory erythroid kinase; REDK; Dual specificity tyrosine-phosphorylation-regulated kinase 3 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | DYRK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Harmine | Ligand Info | |||||
| Structure Description | Crystal structure of kinase | PDB:5Y86 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
VVPLTPEQAL
147 KQYKHHLTAY157 EKLEIINYPE167 IYFVGPNAKK177 RHGVIGGPNN187 GGYDDADGAY 197 IHVPRDHLAY207 RYEVLKIIGK217 GSFGQVARVY227 DHKLRQYVAL237 KMVRNEKRFH 247 RQAAEEIRIL257 EHLKKQDKTG267 SMNVIHMLES277 FTFRNHVCMA287 FELLSIDLYE 297 LIKKNKFQGF307 SVQLVRKFAQ317 SILQSLDALH327 KNKIIHCDLK337 PENILLKHHG 347 RSTKVIDFGS358 SCFEYQKLYT368 IQSRFYRAPE379 IILGSRYSTP389 IDIWSFGCIL 399 AELLTGQPLF409 PGEDEGDQLA419 CMMELLGMPP429 PKLLEQSKRA439 KYFINKGIPR 450 YCSVTTQADG460 RVVLVGGRSR470 RGKKRGPPGS480 KDWGTALKGC490 DDYLFIEFLK 500 RCLHWDPSAR510 LPAQALRHPW521 ISKSVPRPLT531 T
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| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Crystal structure of kinase | PDB:5Y86 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
VVPLTPEQAL
147 KQYKHHLTAY157 EKLEIINYPE167 IYFVGPNAKK177 RHGVIGGPNN187 GGYDDADGAY 197 IHVPRDHLAY207 RYEVLKIIGK217 GSFGQVARVY227 DHKLRQYVAL237 KMVRNEKRFH 247 RQAAEEIRIL257 EHLKKQDKTG267 SMNVIHMLES277 FTFRNHVCMA287 FELLSIDLYE 297 LIKKNKFQGF307 SVQLVRKFAQ317 SILQSLDALH327 KNKIIHCDLK337 PENILLKHHG 347 RSTKVIDFGS358 SCFEYQKLYT368 IQSRFYRAPE379 IILGSRYSTP389 IDIWSFGCIL 399 AELLTGQPLF409 PGEDEGDQLA419 CMMELLGMPP429 PKLLEQSKRA439 KYFINKGIPR 450 YCSVTTQADG460 RVVLVGGRSR470 RGKKRGPPGS480 KDWGTALKGC490 DDYLFIEFLK 500 RCLHWDPSAR510 LPAQALRHPW521 ISKSVPRPLT531 T
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Crystal structure of kinase | PDB:5Y86 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
VVPLTPEQAL
147 KQYKHHLTAY157 EKLEIINYPE167 IYFVGPNAKK177 RHGVIGGPNN187 GGYDDADGAY 197 IHVPRDHLAY207 RYEVLKIIGK217 GSFGQVARVY227 DHKLRQYVAL237 KMVRNEKRFH 247 RQAAEEIRIL257 EHLKKQDKTG267 SMNVIHMLES277 FTFRNHVCMA287 FELLSIDLYE 297 LIKKNKFQGF307 SVQLVRKFAQ317 SILQSLDALH327 KNKIIHCDLK337 PENILLKHHG 347 RSTKVIDFGS358 SCFEYQKLYT368 IQSRFYRAPE379 IILGSRYSTP389 IDIWSFGCIL 399 AELLTGQPLF409 PGEDEGDQLA419 CMMELLGMPP429 PKLLEQSKRA439 KYFINKGIPR 450 YCSVTTQADG460 RVVLVGGRSR470 RGKKRGPPGS480 KDWGTALKGC490 DDYLFIEFLK 500 RCLHWDPSAR510 LPAQALRHPW521 ISKSVPRPLT531 T
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TPO or .TPO2 or .TPO3 or :3TPO;style chemicals stick;color identity;select .A:324 or .A:327 or .A:392 or .A:510 or .A:511 or .A:513 or .A:514 or .A:515 or .A:516 or .A:518; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Phosphonotyrosine | Ligand Info | |||||
| Structure Description | Crystal structure of kinase | PDB:5Y86 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
VVPLTPEQAL
147 KQYKHHLTAY157 EKLEIINYPE167 IYFVGPNAKK177 RHGVIGGPNN187 GGYDDADGAY 197 IHVPRDHLAY207 RYEVLKIIGK217 GSFGQVARVY227 DHKLRQYVAL237 KMVRNEKRFH 247 RQAAEEIRIL257 EHLKKQDKTG267 SMNVIHMLES277 FTFRNHVCMA287 FELLSIDLYE 297 LIKKNKFQGF307 SVQLVRKFAQ317 SILQSLDALH327 KNKIIHCDLK337 PENILLKHHG 347 RSTKVIDFGS358 SCFEYQKLYT368 IQSRFYRAPE379 IILGSRYSTP389 IDIWSFGCIL 399 AELLTGQPLF409 PGEDEGDQLA419 CMMELLGMPP429 PKLLEQSKRA439 KYFINKGIPR 450 YCSVTTQADG460 RVVLVGGRSR470 RGKKRGPPGS480 KDWGTALKGC490 DDYLFIEFLK 500 RCLHWDPSAR510 LPAQALRHPW521 ISKSVPRPLT531 T
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:367 or .A:368 or .A:370 or .A:371 or .A:373 or .A:376 or .A:380 or .A:414; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation. J Mol Biol. 2018 May 11;430(10):1521-1530. | ||||
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