Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98062 | Target Info | |||
| Target Name | Glycogen phosphorylase muscle form (GP) | ||||
| Synonyms | Muscle glycogen phosphorylase; Glycogen phosphorylase, muscle form; Glycogen phosphorylase b | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | PYGM | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenine | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | PDB:1Z8D | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPLSDQEKRK
11 QIVRGVENVT25 ELKKNFNRHL35 HFTLVKDRNV45 ATPRDYYFAL55 AHTVRDHLVG 65 RWIRTQQHYY75 EKDPKRIYYL85 SLEFYMGRTL95 QNTMVNLALE105 NACDEATYQL 115 GLDMEELEEI125 EEDAGLGNGG135 LGRLAACFLD145 SMATLGLAAY155 GYGIRYEFGI 165 FNQKISGGWQ175 MEEADDWLRY185 GNPWEKARPE195 FTLPVHFYGH205 VEHTSQGAKW 215 VDTQVVLAMP225 YDTPVPGYRN235 NVVNTMRLWS245 AKAPGYIQAV266 LDRNLAENIS 276 RVLYPNDNFF286 EGKELRLKQE296 YFVVAATLQD306 IIRRFKSSKF316 GCRDPVRTNF 326 DAFPDKVAIQ336 LNDTHPSLAI346 PELMRILVDL356 ERMDWDKAWD366 VTVRTCAYTN 376 HTVLPEALER386 WPVHLLETLL396 PRHLQIIYEI406 NQRFLNRVAA416 AFPGDVDRLR 426 RMSLVEEGAV436 KRINMAHLCI446 AGSHAVNGVA456 RIHSEILKKT466 IFKDFYELEP 476 HKFQNKTNGI486 TPRRWLVLCN496 PGLAEVIAER506 IGEDFISDLD516 QLRKLLSFVD 526 DEAFIRDVAK536 VKQENKLKFA546 AYLEREYKVH556 INPNSLFDIQ566 VKRIHEYKRQ 576 LLNCLHVITL586 YNRIKREPNK596 FFVPRTVMIG606 GKAAPGYHMA616 KMIIRLVTAI 626 GDVVNHDPAV636 GDRLRVIFLE646 NYRVSLAEKV656 IPAADLSEQI666 STAGTEASGT 676 GNMFMLNGAL687 TIGTMDGANV697 EMAEEAGEEN707 FFIFGMRVED717 VDKLDQRGYN 727 AQEYYDRIPE737 LRQVIEQLSS747 GFFSPKQPDL757 FKDIVNMLMH767 HDRFKVFADY 777 EDYIKCQEKV787 SALYKNPREW797 TRMVIRNIAT807 SGKFSSDRTI817 AQYAREIWGV 827 EPSRQRLPA
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| Ligand Name: Adenosine monophosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | PDB:1Z8D | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPLSDQEKRK
11 QIVRGVENVT25 ELKKNFNRHL35 HFTLVKDRNV45 ATPRDYYFAL55 AHTVRDHLVG 65 RWIRTQQHYY75 EKDPKRIYYL85 SLEFYMGRTL95 QNTMVNLALE105 NACDEATYQL 115 GLDMEELEEI125 EEDAGLGNGG135 LGRLAACFLD145 SMATLGLAAY155 GYGIRYEFGI 165 FNQKISGGWQ175 MEEADDWLRY185 GNPWEKARPE195 FTLPVHFYGH205 VEHTSQGAKW 215 VDTQVVLAMP225 YDTPVPGYRN235 NVVNTMRLWS245 AKAPGYIQAV266 LDRNLAENIS 276 RVLYPNDNFF286 EGKELRLKQE296 YFVVAATLQD306 IIRRFKSSKF316 GCRDPVRTNF 326 DAFPDKVAIQ336 LNDTHPSLAI346 PELMRILVDL356 ERMDWDKAWD366 VTVRTCAYTN 376 HTVLPEALER386 WPVHLLETLL396 PRHLQIIYEI406 NQRFLNRVAA416 AFPGDVDRLR 426 RMSLVEEGAV436 KRINMAHLCI446 AGSHAVNGVA456 RIHSEILKKT466 IFKDFYELEP 476 HKFQNKTNGI486 TPRRWLVLCN496 PGLAEVIAER506 IGEDFISDLD516 QLRKLLSFVD 526 DEAFIRDVAK536 VKQENKLKFA546 AYLEREYKVH556 INPNSLFDIQ566 VKRIHEYKRQ 576 LLNCLHVITL586 YNRIKREPNK596 FFVPRTVMIG606 GKAAPGYHMA616 KMIIRLVTAI 626 GDVVNHDPAV636 GDRLRVIFLE646 NYRVSLAEKV656 IPAADLSEQI666 STAGTEASGT 676 GNMFMLNGAL687 TIGTMDGANV697 EMAEEAGEEN707 FFIFGMRVED717 VDKLDQRGYN 727 AQEYYDRIPE737 LRQVIEQLSS747 GFFSPKQPDL757 FKDIVNMLMH767 HDRFKVFADY 777 EDYIKCQEKV787 SALYKNPREW797 TRMVIRNIAT807 SGKFSSDRTI817 AQYAREIWGV 827 EPSRQRLPA
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| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | PDB:1Z8D | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPLSDQEKRK
11 QIVRGVENVT25 ELKKNFNRHL35 HFTLVKDRNV45 ATPRDYYFAL55 AHTVRDHLVG 65 RWIRTQQHYY75 EKDPKRIYYL85 SLEFYMGRTL95 QNTMVNLALE105 NACDEATYQL 115 GLDMEELEEI125 EEDAGLGNGG135 LGRLAACFLD145 SMATLGLAAY155 GYGIRYEFGI 165 FNQKISGGWQ175 MEEADDWLRY185 GNPWEKARPE195 FTLPVHFYGH205 VEHTSQGAKW 215 VDTQVVLAMP225 YDTPVPGYRN235 NVVNTMRLWS245 AKAPGYIQAV266 LDRNLAENIS 276 RVLYPNDNFF286 EGKELRLKQE296 YFVVAATLQD306 IIRRFKSSKF316 GCRDPVRTNF 326 DAFPDKVAIQ336 LNDTHPSLAI346 PELMRILVDL356 ERMDWDKAWD366 VTVRTCAYTN 376 HTVLPEALER386 WPVHLLETLL396 PRHLQIIYEI406 NQRFLNRVAA416 AFPGDVDRLR 426 RMSLVEEGAV436 KRINMAHLCI446 AGSHAVNGVA456 RIHSEILKKT466 IFKDFYELEP 476 HKFQNKTNGI486 TPRRWLVLCN496 PGLAEVIAER506 IGEDFISDLD516 QLRKLLSFVD 526 DEAFIRDVAK536 VKQENKLKFA546 AYLEREYKVH556 INPNSLFDIQ566 VKRIHEYKRQ 576 LLNCLHVITL586 YNRIKREPNK596 FFVPRTVMIG606 GKAAPGYHMA616 KMIIRLVTAI 626 GDVVNHDPAV636 GDRLRVIFLE646 NYRVSLAEKV656 IPAADLSEQI666 STAGTEASGT 676 GNMFMLNGAL687 TIGTMDGANV697 EMAEEAGEEN707 FFIFGMRVED717 VDKLDQRGYN 727 AQEYYDRIPE737 LRQVIEQLSS747 GFFSPKQPDL757 FKDIVNMLMH767 HDRFKVFADY 777 EDYIKCQEKV787 SALYKNPREW797 TRMVIRNIAT807 SGKFSSDRTI817 AQYAREIWGV 827 EPSRQRLPA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:15 or .A:16 or .A:69 or .A:72; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | PDB:1Z8D | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPLSDQEKRK
11 QIVRGVENVT25 ELKKNFNRHL35 HFTLVKDRNV45 ATPRDYYFAL55 AHTVRDHLVG 65 RWIRTQQHYY75 EKDPKRIYYL85 SLEFYMGRTL95 QNTMVNLALE105 NACDEATYQL 115 GLDMEELEEI125 EEDAGLGNGG135 LGRLAACFLD145 SMATLGLAAY155 GYGIRYEFGI 165 FNQKISGGWQ175 MEEADDWLRY185 GNPWEKARPE195 FTLPVHFYGH205 VEHTSQGAKW 215 VDTQVVLAMP225 YDTPVPGYRN235 NVVNTMRLWS245 AKAPGYIQAV266 LDRNLAENIS 276 RVLYPNDNFF286 EGKELRLKQE296 YFVVAATLQD306 IIRRFKSSKF316 GCRDPVRTNF 326 DAFPDKVAIQ336 LNDTHPSLAI346 PELMRILVDL356 ERMDWDKAWD366 VTVRTCAYTN 376 HTVLPEALER386 WPVHLLETLL396 PRHLQIIYEI406 NQRFLNRVAA416 AFPGDVDRLR 426 RMSLVEEGAV436 KRINMAHLCI446 AGSHAVNGVA456 RIHSEILKKT466 IFKDFYELEP 476 HKFQNKTNGI486 TPRRWLVLCN496 PGLAEVIAER506 IGEDFISDLD516 QLRKLLSFVD 526 DEAFIRDVAK536 VKQENKLKFA546 AYLEREYKVH556 INPNSLFDIQ566 VKRIHEYKRQ 576 LLNCLHVITL586 YNRIKREPNK596 FFVPRTVMIG606 GKAAPGYHMA616 KMIIRLVTAI 626 GDVVNHDPAV636 GDRLRVIFLE646 NYRVSLAEKV656 IPAADLSEQI666 STAGTEASGT 676 GNMFMLNGAL687 TIGTMDGANV697 EMAEEAGEEN707 FFIFGMRVED717 VDKLDQRGYN 727 AQEYYDRIPE737 LRQVIEQLSS747 GFFSPKQPDL757 FKDIVNMLMH767 HDRFKVFADY 777 EDYIKCQEKV787 SALYKNPREW797 TRMVIRNIAT807 SGKFSSDRTI817 AQYAREIWGV 827 EPSRQRLPA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GLC or .GLC2 or .GLC3 or :3GLC;style chemicals stick;color identity;select .A:135 or .A:136 or .A:139 or .A:283 or .A:284 or .A:377 or .A:455 or .A:484 or .A:573 or .A:574 or .A:672 or .A:673 or .A:674 or .A:675 or .A:676; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N6-((3-Hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methylene)-L-lysine | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | PDB:1Z8D | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
RPLSDQEKRK
11 QIVRGVENVT25 ELKKNFNRHL35 HFTLVKDRNV45 ATPRDYYFAL55 AHTVRDHLVG 65 RWIRTQQHYY75 EKDPKRIYYL85 SLEFYMGRTL95 QNTMVNLALE105 NACDEATYQL 115 GLDMEELEEI125 EEDAGLGNGG135 LGRLAACFLD145 SMATLGLAAY155 GYGIRYEFGI 165 FNQKISGGWQ175 MEEADDWLRY185 GNPWEKARPE195 FTLPVHFYGH205 VEHTSQGAKW 215 VDTQVVLAMP225 YDTPVPGYRN235 NVVNTMRLWS245 AKAPGYIQAV266 LDRNLAENIS 276 RVLYPNDNFF286 EGKELRLKQE296 YFVVAATLQD306 IIRRFKSSKF316 GCRDPVRTNF 326 DAFPDKVAIQ336 LNDTHPSLAI346 PELMRILVDL356 ERMDWDKAWD366 VTVRTCAYTN 376 HTVLPEALER386 WPVHLLETLL396 PRHLQIIYEI406 NQRFLNRVAA416 AFPGDVDRLR 426 RMSLVEEGAV436 KRINMAHLCI446 AGSHAVNGVA456 RIHSEILKKT466 IFKDFYELEP 476 HKFQNKTNGI486 TPRRWLVLCN496 PGLAEVIAER506 IGEDFISDLD516 QLRKLLSFVD 526 DEAFIRDVAK536 VKQENKLKFA546 AYLEREYKVH556 INPNSLFDIQ566 VKRIHEYKRQ 576 LLNCLHVITL586 YNRIKREPNK596 FFVPRTVMIG606 GKAAPGYHMA616 KMIIRLVTAI 626 GDVVNHDPAV636 GDRLRVIFLE646 NYRVSLAEKV656 IPAADLSEQI666 STAGTEASGT 676 GNMFMLNGAL687 TIGTMDGANV697 EMAEEAGEEN707 FFIFGMRVED717 VDKLDQRGYN 727 AQEYYDRIPE737 LRQVIEQLSS747 GFFSPKQPDL757 FKDIVNMLMH767 HDRFKVFADY 777 EDYIKCQEKV787 SALYKNPREW797 TRMVIRNIAT807 SGKFSSDRTI817 AQYAREIWGV 827 EPSRQRLPA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LLP or .LLP2 or .LLP3 or :3LLP;style chemicals stick;color identity;select .A:90 or .A:133 or .A:134 or .A:135 or .A:138 or .A:486 or .A:491 or .A:567 or .A:568 or .A:574 or .A:648 or .A:649 or .A:650 or .A:653 or .A:657 or .A:665 or .A:672 or .A:675 or .A:676 or .A:677 or .A:678 or .A:679 or .A:681 or .A:682 or .A:683 or .A:684; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR90
3.657
ASN133
4.948
GLY134
3.850
GLY135
3.697
ARG138
3.923
ILE486
3.317
TRP491
3.682
VAL567
4.365
LYS568
2.966
LYS574
2.918
TYR648
3.410
ARG649
3.323
VAL650
3.338
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features. Proteins. 2006 Jun 1;63(4):1123-6. | ||||
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