Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05387 | Target Info | |||
| Target Name | Tissue transglutaminase (TG2) | ||||
| Synonyms | Transglutaminase-2; Transglutaminase H; Transglutaminase C; Transglutaminase 2; Tranglutaminase 2; TTg; TGase-H; TGase-2; TGase H; TGase C; TGC; TG(C)Protein-glutamine gamma-glutamyltransferase; TG(C); Protein-glutamine gamma-glutamyltransferase 2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TGM2 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Guanosine-5'-Diphosphate | Ligand Info | |||
| Canonical SMILES | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N | ||||
| InChI | 1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 | ||||
| InChIKey | QGWNDRXFNXRZMB-UUOKFMHZSA-N | ||||
| PubChem Compound ID | 135398619 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1KV3 HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
ETNGRDHHTA
24 DLCREKLVVR34 RGQPFWLTLS56 LTFSVVTGPA66 PSQEAGTKAR76 FPLRDAVEEG 86 DWTATVVDQQ96 DCTLSLQLTT106 PANAPIGLYR116 LSLEASGHFI136 LLFNAWCPAD 146 AVYLDSEEER156 QEYVLTQQGF166 IYQGSAKFIK176 NIPWNFGQFQ186 DGILDICLIL 196 LDVNPKFLKN206 AGRDCSRRSS216 PVYVGRVGSG226 MVNCNDDQGV236 LLGRWDNNYG 246 DGVSPMSWIG256 SVDILRRWKN266 HGCQRVKYGQ276 CWVFAAVACT286 VLRCLGIPTR 296 VVTNYNSAHD306 QNSNLLIEYF316 RNEFGEIQGD326 KSEMIWNFHC336 WVESWMTRPD 346 LQPGYEGWQA356 LDPTPQEKSE366 GTYCCGPVPV376 RAIKEGDLST386 KYDAPFVFAE 396 VNADVVDWIQ406 QDDGSVHKSI416 NRSLIVGLKI426 STKSVGRDER436 EDITHTYKYP 446 EGSSEEREAF456 TRANHLNKLA466 EKEETGMAMR476 IRVGQSMNMG486 SDFDVFAHIT 496 NNTAEEYVCR506 LLLCARTVSY516 NGILGPECGT526 KYLLNLTLEP536 FSEKSVPLCI 546 LYEKYRDCLT556 ESNLIKVRAL566 LVEPVINSYL576 LAERDLYLEN586 PEIKIRILGE 596 PKQKRKLVAE606 VSLQNPLPVA616 LEGCTFTVEG626 AGLTEEQKTV636 EIPDPVEAGE 646 EVKVRMDLVP656 LHMGLHKLVV666 NFESDKLKAV676 KGFRNVIIGP686 A |
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| PDB ID: 6KZB Transglutaminase2 complexed with calcium | ||||||
| Method | X-ray diffraction | Resolution | 3.55 Å | Mutation | No | [2] |
| PDB Sequence |
AEELVLERCD
11 LELETNGRDH21 HTADLCREKL31 VVRRGQPFWL41 TLHFEGRNYE51 ASVDSLTFSV 61 VTGPAPSQEA71 GTKARFPLRD81 AVGDWTATVV93 DQQDCTLSLQ103 LTTPANAPIG 113 LYRLSLEAST123 GYQGSSFVLG133 HFILLFNAWC143 PADAVYLDSE153 EERQEYVLTQ 163 QGFIYQGSAK173 FIKNIPWNFG183 QFEDGILDIC193 LILLDVNPKF203 LKNAGRDCSR 213 RSSPVYVGRV223 VSGMVNCNDD233 QGVLLGRWDN243 NYGDGVSPMS253 WIGSVDILRR 263 WKNHGCQRVK273 YGQCWVFAAV283 ACTVLRCLGI293 PTRVVTNYNS303 AHDQNSNLLI 313 EYFRNEFGEI323 QGDKSEMIWN333 FHCWVESWMT343 RPDLQPGYEG353 WQALDPTPQE 363 KSEGTYCCGP373 VPVRAIKEGD383 LSTKYDAPFV393 FAEVNADVVD403 WIQQDDGSVH 413 KSINRSLIVG423 LKISTKSVGR433 DEREDITHTY443 KYPEGSSEER453 EAFTRANHLN 463 KAEKTGMAMR476 IRVGQSMNMG486 SDFDVFAHIT496 NNTAEEYVCR506 LLLCARTVSY 516 NGILGPECGT526 KYLLNLNLEP536 FSEKSVPLCI546 LYEKYRDCLT556 ESNLIKVRAL 566 LVEPVINSYL576 LAERDLYLEN586 PEIKIRILGE596 PKQKRKLVAE606 VSLQNPLPVA 616 LEGCTFTVEG626 AGLTEEQKTV636 EIPDPVEAGE646 EVKVRMDLLP656 LHMGLHKLVV 666 NFESDKLKAV676 KGFRNVIIGP686 A
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2743-7. | ||||
| REF 2 | Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2. Int J Mol Sci. 2020 Jan 25;21(3):791. | ||||
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