Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15851 | Target Info | |||
| Target Name | Orotidine 5'-monophosphate decarboxylase (UMPS) | ||||
| Synonyms | Uridine 5'-monophosphate synthase; UMP synthase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | UMPS | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | N6-Acetyl-L-lysine | Ligand Info | |||
| Canonical SMILES | CC(=O)NCCCCC(C(=O)O)N | ||||
| InChI | 1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1 | ||||
| InChIKey | DTERQYGMUDWYAZ-ZETCQYMHSA-N | ||||
| PubChem Compound ID | 92832 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7AM9 OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 0.99 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
||||||
| PDB ID: 6YWT Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
||||||
| PDB ID: 6YWU Human OMPD-domain of UMPS (K314AcK) in complex with UMP at 1.1 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
||||||
| PDB ID: 6YVK Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 0.71 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6YVL Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 1.42 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6YVM Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6YVN Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6YVO Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6ZX0 OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 7OQF Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373 or .A:316 or .A:317 or .A:318 or .A:346 or .B:316 or .B:317 or .B:318 or .B:346 or .B:312 or .B:313 or .B:315 or .B:316 or .B:341 or .B:342 or .B:343 or .B:368 or .B:371 or .B:373; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP312[A]
3.350
ARG313[A]
1.336
PHE315[A]
1.339
ALA316[A]
3.313
ASN341[A]
2.883
ALA342[A]
4.373
HIS343[A]
3.250
ILE368[A]
3.587
MET371[A]
2.962
SER373[A]
4.374
ALA316[A]
3.367
ASP317[A]
2.980
ILE318[A]
3.885
PRO346[A]
4.252
|
|||||
| PDB ID: 7OQM Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373 or .A:316 or .A:317 or .A:318 or .A:346 or .B:316 or .B:317 or .B:318 or .B:346 or .B:312 or .B:313 or .B:315 or .B:316 or .B:341 or .B:342 or .B:343 or .B:368 or .B:371 or .B:373; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP312[A]
3.376
ARG313[A]
1.334
PHE315[A]
1.337
ALA316[A]
3.298
ASN341[A]
2.873
ALA342[A]
4.388
HIS343[A]
3.296
ILE368[A]
3.593
MET371[A]
2.839
SER373[A]
4.376
ALA316[A]
3.368
ASP317[A]
2.984
ILE318[A]
3.873
PRO346[A]
4.255
|
|||||
| PDB ID: 7OQK Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:316 or .A:317 or .A:318 or .A:346 or .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373 or .B:312 or .B:313 or .B:315 or .B:316 or .B:341 or .B:342 or .B:343 or .B:368 or .B:371 or .B:373 or .B:316 or .B:317 or .B:318 or .B:346; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA316[A]
3.367
ASP317[A]
2.991
ILE318[A]
3.880
PRO346[A]
4.262
ASP312[A]
3.368
ARG313[A]
1.330
PHE315[A]
1.340
ALA316[A]
3.308
ASN341[A]
2.886
ALA342[A]
4.378
HIS343[A]
3.286
ILE368[A]
3.593
MET371[A]
2.996
SER373[A]
4.395
|
|||||
| PDB ID: 7OQN Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373 or .A:316 or .A:317 or .A:318 or .A:346 or .B:316 or .B:317 or .B:318 or .B:346 or .B:312 or .B:313 or .B:315 or .B:316 or .B:341 or .B:342 or .B:343 or .B:368 or .B:371 or .B:373; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP312[A]
3.385
ARG313[A]
1.332
PHE315[A]
1.335
ALA316[A]
3.304
ASN341[A]
2.887
ALA342[A]
4.368
HIS343[A]
3.303
ILE368[A]
3.604
MET371[A]
2.812
SER373[A]
4.373
ALA316[A]
3.377
ASP317[A]
2.989
ILE318[A]
3.878
PRO346[A]
4.237
|
|||||
| PDB ID: 7OQI Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:312 or .A:313 or .A:315 or .A:316 or .A:341 or .A:342 or .A:343 or .A:368 or .A:371 or .A:373 or .A:316 or .A:317 or .A:318 or .A:346 or .B:316 or .B:317 or .B:318 or .B:346 or .B:312 or .B:313 or .B:315 or .B:316 or .B:341 or .B:342 or .B:343 or .B:368 or .B:371 or .B:373; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP312[A]
3.372
ARG313[A]
1.335
PHE315[A]
1.335
ALA316[A]
3.307
ASN341[A]
2.885
ALA342[A]
4.382
HIS343[A]
3.268
ILE368[A]
3.593
MET371[A]
2.993
SER373[A]
4.386
ALA316[A]
3.374
ASP317[A]
2.984
ILE318[A]
3.891
PRO346[A]
4.258
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis. doi:10.1038/s41929-022-00771-w. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.