Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15851 | Target Info | |||
| Target Name | Orotidine 5'-monophosphate decarboxylase (UMPS) | ||||
| Synonyms | Uridine 5'-monophosphate synthase; UMP synthase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | UMPS | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Thiocysteine | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)SS | ||||
| InChI | 1S/C3H7NO2S2/c4-2(1-8-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 | ||||
| InChIKey | XBKONSCREBSMCS-REOHCLBHSA-N | ||||
| PubChem Compound ID | 165331 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7OTU Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2 | ||||||
| Method | X-ray diffraction | Resolution | 0.95 Å | Mutation | No | [1] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFEDR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLG |
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| PDB ID: 7AM9 OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 0.99 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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| PDB ID: 6ZWY OMPD-domain of human UMPS in complex with UMP at 1.0 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.00 Å | Mutation | No | [1] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFEDR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLG |
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| PDB ID: 6ZX1 OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.00 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRK314 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YWT Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YWU Human OMPD-domain of UMPS (K314AcK) in complex with UMP at 1.1 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2QCF Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 5-fluoro-UMP | ||||||
| Method | X-ray diffraction | Resolution | 1.22 Å | Mutation | Yes | [2] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFENR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YVK Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 0.71 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YVL Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 1.42 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YVM Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YVN Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6YVO Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6ZX0 OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2QCM Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP | ||||||
| Method | X-ray diffraction | Resolution | 1.67 Å | Mutation | Yes | [2] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFENR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2QCD Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [2] |
| PDB Sequence |
AMELSFGARA
231 ELPRIHPVAS241 KLLRLMQKKE251 TNLCLSADVS261 LARELLQLAD271 ALGPSICMLK 281 THVDILNDFT291 LDVMKELITL301 AKHEFLIFED312 RKFADIGNTV322 KKQYEGGIFK 332 IASWADLVNA342 HVVPGSGVVK352 GLQEVGLPLH362 RGCLLIAEMS372 STGSLATGDY 382 TRAAVRMAEE392 HSEFVVGFIS402 GSRVSMKPEF412 LHLTPGVQLE422 AGGDNLGQQY 432 NSPQEVIGKR442 GSDIIIVGRG452 IISAADRLEA462 AEMYRKAAWE472 AYLSRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:271 or .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7ASQ Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the reaction product UMP at 0.95 Angstrom resolution | ||||||
| Method | X-ray diffraction | Resolution | 0.95 Å | Mutation | No | [1] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFEDR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRL |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7Q1H Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.31 Å | Mutation | Yes | [1] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFENR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLGV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7OUZ Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.9 Angstroms resolution, crystal 1 | ||||||
| Method | X-ray diffraction | Resolution | 0.90 Å | Mutation | No | [1] |
| PDB Sequence |
MELSFGARAE
232 LPRIHPVASK242 LLRLMQKKET252 NLCLSADVSL262 ARELLQLADA272 LGPSICMLKT 282 HVDILNDFTL292 DVMKELITLA302 KHEFLIFEDR313 KFADIGNTVK323 KQYEGGIFKI 333 ASWADLVNAH343 VVPGSGVVKG353 LQEVGLPLHR363 GCLLIAEMSS373 TGSLATGDYT 383 RAAVRMAEEH393 SEFVVGFISG403 SRVSMKPEFL413 HLTPGVQLEA423 GGDNLGQQYN 433 SPQEVIGKRG443 SDIIIVGRGI453 ISAADRLEAA463 EMYRKAAWEA473 YLSRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7OQF Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7OQM Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7OQK Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7OQN Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
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| PDB ID: 7OQI Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSS or .CSS2 or .CSS3 or :3CSS;style chemicals stick;color identity;select .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:305 or .A:306; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis. doi:10.1038/s41929-022-00771-w. | ||||
| REF 2 | Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure. 2008 Jan;16(1):82-92. | ||||
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