Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15851 | Target Info | |||
| Target Name | Orotidine 5'-monophosphate decarboxylase (UMPS) | ||||
| Synonyms | Uridine 5'-monophosphate synthase; UMP synthase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | UMPS | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Uridine-5'-Monophosphate | Ligand Info | |||
| Canonical SMILES | C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O | ||||
| InChI | 1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 | ||||
| InChIKey | DJJCXFVJDGTHFX-XVFCMESISA-N | ||||
| PubChem Compound ID | 6030 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7AM9 OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 0.99 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
SER257
3.166
ASP259
2.816
LYS281
2.759
HIS283
2.956
ASP312
3.613
GLU370
4.311
MET371
3.229
SER372
2.810
SER373
4.929
ILE401
4.033
|
|||||
| PDB ID: 6YVK Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 0.71 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
SER257
3.171
ASP259
2.707
LYS281
2.887
HIS283
2.978
ASP312
3.575
GLU370
4.302
MET371
3.246
SER372
2.793
SER373
4.925
ILE401
3.859
|
|||||
| PDB ID: 6YVL Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 1.42 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
|
SER257
3.107
ASP259
2.784
LYS281
2.738
HIS283
2.961
ASP312
3.584
GLU370
4.307
MET371
3.249
SER372
2.819
SER373
4.922
ILE401
3.939
|
|||||
| PDB ID: 6YVM Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257
3.119
ASP259
2.798
LYS281
2.727
HIS283
2.959
ASP312
3.596
GLU370
4.295
MET371
3.249
SER372
2.809
SER373
4.930
ILE401
3.938
|
|||||
| PDB ID: 6YVN Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257
3.115
ASP259
2.790
LYS281
2.727
HIS283
2.968
ASP312
3.596
GLU370
4.310
MET371
3.255
SER372
2.812
SER373
4.929
ILE401
3.951
|
|||||
| PDB ID: 6YVO Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257
3.119
ASP259
2.799
LYS281
2.723
HIS283
2.964
ASP312
3.621
GLU370
4.318
MET371
3.259
SER372
2.814
SER373
4.919
ILE401
3.958
|
|||||
| PDB ID: 6ZX0 OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELSFGARAEL
233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257
3.133
ASP259
2.761
LYS281
2.798
HIS283
2.985
ASP312
3.577
GLU370
4.301
MET371
3.249
SER372
2.843
SER373
4.970
ILE401
3.940
|
|||||
| PDB ID: 7OQF Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452 or .A:317 or .A:318 or .A:321 or .B:317 or .B:318 or .B:321 or .B:257 or .B:259 or .B:281 or .B:283 or .B:312 or .B:370 or .B:371 or .B:372 or .B:401 or .B:417 or .B:418 or .B:419 or .B:430 or .B:432 or .B:448 or .B:449 or .B:450 or .B:451 or .B:452; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257[A]
3.175
ASP259[A]
2.804
LYS281[A]
2.793
HIS283[A]
2.974
ASP312[A]
3.557
GLU370[A]
4.264
MET371[A]
3.267
SER372[A]
2.837
SER373[A]
4.983
ILE401[A]
3.954
PRO417[A]
3.327
GLY418[A]
4.359
VAL419[A]
4.406
GLN430[A]
2.793
TYR432[A]
2.686
ILE448[A]
3.986
VAL449[A]
4.105
GLY450[A]
3.041
ARG451[A]
2.659
GLY452[A]
4.917
ASP317[A]
2.533
ILE318[A]
3.644
THR321[A]
2.843
ASP317[B]
2.505
ILE318[B]
3.640
THR321[B]
2.855
SER257[B]
3.160
ASP259[B]
2.788
LYS281[B]
2.816
HIS283[B]
2.964
ASP312[B]
3.536
GLU370[B]
4.243
MET371[B]
3.256
SER372[B]
2.837
ILE401[B]
3.959
PRO417[B]
3.293
GLY418[B]
4.359
VAL419[B]
4.391
GLN430[B]
2.802
TYR432[B]
2.697
ILE448[B]
3.998
VAL449[B]
4.058
GLY450[B]
2.996
ARG451[B]
2.722
GLY452[B]
4.909
|
|||||
| PDB ID: 7OQM Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.05 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452 or .A:317 or .A:318 or .A:321 or .B:317 or .B:318 or .B:321 or .B:257 or .B:259 or .B:281 or .B:283 or .B:312 or .B:370 or .B:371 or .B:372 or .B:401 or .B:417 or .B:418 or .B:419 or .B:430 or .B:432 or .B:448 or .B:449 or .B:450 or .B:451 or .B:452; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257[A]
3.194
ASP259[A]
2.728
LYS281[A]
2.886
HIS283[A]
2.948
ASP312[A]
3.478
GLU370[A]
4.249
MET371[A]
3.287
SER372[A]
2.799
ILE401[A]
4.005
PRO417[A]
3.254
GLY418[A]
4.344
VAL419[A]
4.382
GLN430[A]
2.922
TYR432[A]
2.671
ILE448[A]
4.104
VAL449[A]
4.009
GLY450[A]
2.921
ARG451[A]
2.758
GLY452[A]
4.816
ASP317[A]
2.606
ILE318[A]
3.594
THR321[A]
2.823
ASP317[B]
2.592
ILE318[B]
3.619
THR321[B]
2.798
SER257[B]
3.187
ASP259[B]
2.695
LYS281[B]
2.897
HIS283[B]
2.965
ASP312[B]
3.456
GLU370[B]
4.244
MET371[B]
3.255
SER372[B]
2.795
ILE401[B]
3.980
PRO417[B]
3.253
GLY418[B]
4.375
VAL419[B]
4.394
GLN430[B]
2.929
TYR432[B]
2.671
ILE448[B]
4.102
VAL449[B]
3.993
GLY450[B]
2.908
ARG451[B]
2.744
GLY452[B]
4.784
|
|||||
| PDB ID: 7OQK Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:317 or .A:318 or .A:321 or .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452 or .B:257 or .B:259 or .B:281 or .B:283 or .B:312 or .B:370 or .B:371 or .B:372 or .B:401 or .B:417 or .B:418 or .B:419 or .B:430 or .B:432 or .B:448 or .B:449 or .B:450 or .B:451 or .B:452 or .B:317 or .B:318 or .B:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP317[A]
2.616
ILE318[A]
3.581
THR321[A]
2.826
SER257[A]
3.176
ASP259[A]
2.755
LYS281[A]
2.818
HIS283[A]
2.931
ASP312[A]
3.524
GLU370[A]
4.246
MET371[A]
3.272
SER372[A]
2.782
ILE401[A]
4.012
PRO417[A]
3.291
GLY418[A]
4.344
VAL419[A]
4.406
GLN430[A]
2.905
TYR432[A]
2.735
ILE448[A]
4.080
VAL449[A]
4.011
GLY450[A]
2.917
ARG451[A]
2.759
GLY452[A]
4.800
SER257[B]
3.192
ASP259[B]
2.703
LYS281[B]
2.910
HIS283[B]
2.957
ASP312[B]
3.457
GLU370[B]
4.247
MET371[B]
3.276
SER372[B]
2.796
ILE401[B]
3.986
PRO417[B]
3.242
GLY418[B]
4.394
VAL419[B]
4.402
GLN430[B]
2.935
TYR432[B]
2.656
ILE448[B]
4.098
VAL449[B]
3.997
GLY450[B]
2.906
ARG451[B]
2.757
GLY452[B]
4.775
ASP317[B]
2.573
ILE318[B]
3.606
THR321[B]
2.796
|
|||||
| PDB ID: 7OQN Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452 or .A:317 or .A:318 or .A:321 or .B:317 or .B:318 or .B:321 or .B:257 or .B:259 or .B:281 or .B:283 or .B:312 or .B:370 or .B:371 or .B:372 or .B:401 or .B:417 or .B:418 or .B:419 or .B:430 or .B:432 or .B:448 or .B:449 or .B:450 or .B:451 or .B:452; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257[A]
3.179
ASP259[A]
2.690
LYS281[A]
2.912
HIS283[A]
2.967
ASP312[A]
3.439
GLU370[A]
4.245
MET371[A]
3.287
SER372[A]
2.782
ILE401[A]
3.983
PRO417[A]
3.262
GLY418[A]
4.384
VAL419[A]
4.409
GLN430[A]
2.898
TYR432[A]
2.644
ILE448[A]
4.104
VAL449[A]
3.979
GLY450[A]
2.884
ARG451[A]
2.736
GLY452[A]
4.780
ASP317[A]
2.602
ILE318[A]
3.586
THR321[A]
2.830
ASP317[B]
2.606
ILE318[B]
3.591
THR321[B]
2.824
SER257[B]
3.191
ASP259[B]
2.709
LYS281[B]
2.899
HIS283[B]
2.952
ASP312[B]
3.445
GLU370[B]
4.235
MET371[B]
3.271
SER372[B]
2.791
ILE401[B]
3.985
PRO417[B]
3.263
GLY418[B]
4.385
VAL419[B]
4.417
GLN430[B]
2.933
TYR432[B]
2.665
ILE448[B]
4.094
VAL449[B]
3.988
GLY450[B]
2.895
ARG451[B]
2.748
GLY452[B]
4.777
|
|||||
| PDB ID: 7OQI Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking | ||||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 HEFLIFEDRF315 ADIGNTVKKQ325 YEGGIFKIAS 335 WADLVNAHVV345 PGSGVVKGLQ355 EVGLPLHRGC365 LLIAEMSSTG375 SLATGDYTRA 385 AVRMAEEHSE395 FVVGFISGSR405 VSMKPEFLHL415 TPGVQLEAGG425 DNLGQQYNSP 435 QEVIGKRGSD445 IIIVGRGIIS455 AADRLEAAEM465 YRKAAWEAYL475 SRLG > Chain B ELSFGARAEL 233 PRIHPVASKL243 LRLMQKKETN253 LCLSADVSLA263 RELLQLADAL273 GPSICMLKTH 283 VDILNDFTLD293 VMKELITLAK303 CHEFLIFEDR313 FADIGNTVKK324 QYEGGIFKIA 334 SWADLVNAHV344 VPGSGVVKGL354 QEVGLPLHRG364 CLLIAEMSST374 GSLATGDYTR 384 AAVRMAEEHS394 EFVVGFISGS404 RVSMKPEFLH414 LTPGVQLEAG424 GDNLGQQYNS 434 PQEVIGKRGS444 DIIIVGRGII454 SAADRLEAAE464 MYRKAAWEAY474 LSRLG |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .U or .U2 or .U3 or :3U;style chemicals stick;color identity;select .A:257 or .A:259 or .A:281 or .A:283 or .A:312 or .A:370 or .A:371 or .A:372 or .A:373 or .A:401 or .A:417 or .A:418 or .A:419 or .A:430 or .A:432 or .A:448 or .A:449 or .A:450 or .A:451 or .A:452 or .A:317 or .A:318 or .A:321 or .B:317 or .B:318 or .B:321 or .B:257 or .B:259 or .B:281 or .B:283 or .B:312 or .B:370 or .B:371 or .B:372 or .B:401 or .B:417 or .B:418 or .B:419 or .B:430 or .B:432 or .B:448 or .B:449 or .B:450 or .B:451 or .B:452; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER257[A]
3.170
ASP259[A]
2.782
LYS281[A]
2.809
HIS283[A]
2.945
ASP312[A]
3.523
GLU370[A]
4.307
MET371[A]
3.293
SER372[A]
2.810
SER373[A]
4.957
ILE401[A]
4.046
PRO417[A]
3.316
GLY418[A]
4.295
VAL419[A]
4.418
GLN430[A]
2.916
TYR432[A]
2.688
ILE448[A]
4.026
VAL449[A]
4.037
GLY450[A]
2.952
ARG451[A]
2.732
GLY452[A]
4.888
ASP317[A]
2.611
ILE318[A]
3.658
THR321[A]
2.794
ASP317[B]
2.566
ILE318[B]
3.679
THR321[B]
2.835
SER257[B]
3.171
ASP259[B]
2.722
LYS281[B]
2.850
HIS283[B]
2.951
ASP312[B]
3.479
GLU370[B]
4.258
MET371[B]
3.281
SER372[B]
2.789
ILE401[B]
4.026
PRO417[B]
3.274
GLY418[B]
4.329
VAL419[B]
4.402
GLN430[B]
2.901
TYR432[B]
2.667
ILE448[B]
4.097
VAL449[B]
3.998
GLY450[B]
2.923
ARG451[B]
2.773
GLY452[B]
4.811
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis. doi:10.1038/s41929-022-00771-w. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.