Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T24823 | Target Info | |||
| Target Name | Lysine-specific histone demethylase 1B (KDM1B) | ||||
| Synonyms | Lysine-specific histone demethylase 2; LSD2; Flavin-containing amine oxidase domain-containing protein 1; C6orf193; AOF1 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM1B | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Flavin-Adenine Dinucleotide | Ligand Info | |||
| Canonical SMILES | CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)O | ||||
| InChI | 1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 | ||||
| InChIKey | VWWQXMAJTJZDQX-UYBVJOGSSA-N | ||||
| PubChem Compound ID | 643975 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4FWE Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [1] |
| PDB Sequence |
KYRKCEKAGC
58 TATCPVCFAS68 ASERCAKNGY78 TSRWYHLSCG88 EHFCNECFDH98 YYRSHKDGYD 108 KYTTWKKIWT118 SNGKTEPSPK128 AFMADQQLPY138 WVQCTKPECR148 KWRQLTKEIQ 158 LTPQIAKTYR168 CGMKPNTKPE180 TSDHCSLPED190 LRVLEVSNHW200 WYSMLILPPL 210 LKDSVAAPLL220 SAYYPDCVGM230 SPSCTSTVHV262 PGMNRYFQPF272 YQPNECGKAL 282 CVRPDVMELD292 ELYEFPEYSR302 DPTMYLALRN312 LILALWYTNC322 KEALTPQKCI 332 PHIIVRGLVR342 IRCVQEVERI352 LYFMTRKGLI362 NTGVLSVGAD372 QYLLPKDYHN 382 KSVIIIGAGP392 AGLAAARQLH402 NFGIKVTVLE412 AKDRIGGRVW422 DDKSFKGVTV 432 GRGAQIVNGC442 INNPVALMCE452 QLGISMHKFG462 ERCDLIQEGG472 RITDPTIDKR 482 MDFHFNALLD492 VVSEWRKDKT502 QLQDVPLGEK512 IEEIYKAFIK522 ESGIQFSELE 532 GQVLQFHLSN542 LEYACGSNLH552 QVSARSWDHN562 EFFAQFAGDH572 TLLTPGYSVI 582 IEKLAEGLDI592 QLKSPVQCID602 YSGDEVQVTT612 TDGTGYSAQK622 VLVTVPLALL 632 QKGAIQFNPP642 LSEKKMKAIN652 SLGAGIIEKI662 ALQFPYRFWD672 SKVQGADFFG 682 HVPPSASKRG692 LFAVFYDMDP702 QKKHSVLMSV712 IAGEAVASVR722 TLDDKQVLQQ 732 CMATLRELFK742 EQEVPDPTKY752 FVTRWSTDPW762 IQMAYSFVKT772 GGSGEAYDII 782 AEDIQGTVFF792 AGEATNRHFP802 QTVTGAYLSG812 VREASKIAAF822 |
|||||
|
|
ILE388
3.487
GLY389
3.458
ALA390
4.025
GLY391
3.316
PRO392
3.290
ALA393
2.873
GLY394
4.226
LEU411
3.392
GLU412
2.520
ALA413
3.245
LYS414
3.405
GLY418
3.688
GLY419
3.086
ARG420
2.682
VAL421
4.074
ARG434
3.550
GLY435
3.605
ALA436
3.386
GLN437
3.432
ILE438
2.778
VAL439
4.901
ASN440
4.572
TYR545
4.966
TYR579
3.686
SER596
4.097
PRO597
3.682
VAL598
2.867
THR626
3.524
VAL627
3.374
PRO628
3.315
LEU631
4.064
ILE637
3.667
ILE659
3.841
LYS661
3.902
TRP757
3.468
TRP762
3.151
ILE763
3.634
MET765
3.880
ALA766
3.364
TYR767
3.761
GLY794
3.091
GLU795
2.864
GLN803
2.602
THR804
3.346
VAL805
2.822
THR806
4.382
ALA808
3.283
|
|||||
| PDB ID: 4FWF Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
YRKCEKAGCT
59 ATCPVCFASA69 SERCANGYTS80 RWYHLSCGEH90 FCNECFDHYY100 RSHKDGYDKY 110 TTWKKIWTSN120 GKTEPSPKAF130 MADQQLPYWV140 QCTKPECRKW150 RQLTKEIQLT 160 PQIAKTYRCG170 MKPHCSLPED190 LRVLEVSNHW200 WYSMLILPPL210 LKDSVAAPLL 220 SAYYPDCVGM230 SPSCTSTHVP263 GMNRYFQPFY273 QPNECGKALC283 VRPDVMELDE 293 LYEFPEYSRD303 PTMYLALRNL313 ILALWYTNCK323 EALTPQKCIP333 HIIVRGLVRI 343 RCVQEVERIL353 YFMTRKGLIN363 TGVLSVGADQ373 YLLPKDYHNK383 SVIIIGAGPA 393 GLAAARQLHN403 FGIKVTVLEA413 KDRIGGRVWD423 DKSFKGVTVG433 RGAQIVNGCI 443 NNPVALMCEQ453 LGISMHKFGE463 RCDLIQEGGR473 ITDPTIDKRM483 DFHFNALLDV 493 VSEWRKDKTQ503 LQDVPLGEKI513 EEIYKAFIKE523 SGIQFSELEG533 QVLQFHLSNL 543 EYACGSNLHQ553 VSARSWDHNE563 FFAQFAGDHT573 LLTPGYSVII583 EKLAEGLDIQ 593 LKSPVQCIDY603 SGDEVQVTTT613 DGTGYSAQKV623 LVTVPLALLQ633 KGAIQFNPPL 643 SEKKMKAINS653 LGAGIIEKIA663 LQFPYRFWDS673 KVQGADFFGH683 VPPSASKRGL 693 FAVFYDMDPQ703 KKHSVLMSVI713 AGEAVASVRT723 LDDKQVLQQC733 MATLRELFKE 743 QEVPDPTKYF753 VTRWSTDPWI763 QMAYSFVKTG773 GSGEAYDIIA783 EDIQGTVFFA 793 GEATNRHFPQ803 TVTGAYLSGV813 REASKIAAF
|
|||||
|
|
ILE388
3.646
GLY389
3.231
ALA390
3.971
GLY391
3.492
PRO392
3.225
ALA393
2.873
GLY394
4.269
LEU411
3.207
GLU412
2.466
ALA413
3.168
LYS414
3.295
GLY418
3.865
GLY419
3.291
ARG420
2.705
VAL421
4.323
ARG434
3.416
GLY435
3.385
ALA436
3.342
GLN437
3.373
ILE438
2.827
VAL439
4.997
ASN440
4.291
TYR579
3.611
SER596
4.054
PRO597
3.601
VAL598
2.963
THR626
3.887
VAL627
3.378
PRO628
3.676
LEU631
4.218
ILE637
3.751
ILE659
3.895
LYS661
3.931
TRP757
3.605
TRP762
3.411
ILE763
4.393
MET765
4.174
ALA766
3.455
TYR767
3.870
GLY794
3.289
GLU795
2.873
GLN803
2.567
THR804
3.293
VAL805
2.780
THR806
4.354
ALA808
3.355
|
|||||
| PDB ID: 4FWJ Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
KKYRKCEKAG
57 CTATCPVCFA67 SASERCAKNG77 YTSRWYHLSC87 GEHFCNECFD97 HYYRSHKDGY 107 DKYTTWKKIW117 TSNGKTEPSP127 KAFMADQQLP137 YWVQCTKPEC147 RKWRQLTKEI 157 QLTPQIAKTY167 RCGMKPNTAK178 PETSDHCSLP188 EDLRVLEVSN198 HWWYSMLILP 208 PLLKDSVAAP218 LLSAYYPDCV228 GMSPSCTSTV262 PGMNRYFQPF272 YQPNECGKAL 282 CVRPDVMELD292 ELYEFPEYSR302 DPTMYLALRN312 LILALWYTNC322 KEALTPQKCI 332 PHIIVRGLVR342 IRCVQEVERI352 LYFMTRKGLI362 NTGVLSVGAD372 QYLLPKDYHN 382 KSVIIIGAGP392 AGLAAARQLH402 NFGIKVTVLE412 AKDRIGGRVW422 DDKSFKGVTV 432 GRGAQIVNGC442 INNPVALMCE452 QLGISMHKFG462 ERCDLIQEGG472 RITDPTIDKR 482 MDFHFNALLD492 VVSEWRKDKT502 QLQDVPLGEK512 IEEIYKAFIK522 ESGIQFSELE 532 GQVLQFHLSN542 LEYACGSNLH552 QVSARSWDHN562 EFFAQFAGDH572 TLLTPGYSVI 582 IEKLAEGLDI592 QLKSPVQCID602 YSGDEVQVTT612 TDGTGYSAQK622 VLVTVPLALL 632 QKGAIQFNPP642 LSEKKMKAIN652 SLGAGIIEKI662 ALQFPYRFWD672 SKVQGADFFG 682 HVPPSASKRG692 LFAVFYDMDP702 QKKHSVLMSV712 IAGEAVASVR722 TLDDKQVLQQ 732 CMATLRELFK742 EQEVPDPTKY752 FVTRWSTDPW762 IQMAYSFVKT772 GGSGEAYDII 782 AEDIQGTVFF792 AGEATNRHFP802 QTVTGAYLSG812 VREASKIAAF822 |
|||||
|
|
ILE388
3.530
GLY389
3.531
ALA390
3.957
GLY391
3.816
PRO392
3.458
ALA393
3.007
GLY394
4.922
LEU411
3.671
GLU412
2.615
ALA413
3.166
LYS414
3.300
ARG416
4.961
GLY418
3.803
GLY419
3.348
ARG420
2.569
VAL421
4.532
ARG434
3.567
GLY435
3.575
ALA436
3.374
GLN437
3.475
ILE438
2.898
TYR545
4.688
TYR579
3.690
SER596
3.961
PRO597
3.802
VAL598
2.892
THR626
3.857
VAL627
3.232
PRO628
3.655
LEU631
4.123
ILE637
3.536
ILE659
3.780
LYS661
4.155
TRP757
3.608
TRP762
3.326
ILE763
4.119
MET765
4.006
ALA766
3.502
TYR767
3.701
GLY794
3.557
GLU795
3.180
GLN803
2.603
THR804
3.391
VAL805
2.821
THR806
4.438
ALA808
3.130
|
|||||
| PDB ID: 7XE2 Crystal structure of LSD2 in complex with trans-4-Br-PCPA | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [2] |
| PDB Sequence |
EKKYRKCEKA
56 GCTATCPVCF66 ASASERCAKN76 GYTSRWYHLS86 CGEHFCNECF96 DHYYRSHKDG 106 YDKYTTWKKI116 WTSNGKTEPS126 PKAFMADQQL136 PYWVQCTKPE146 CRKWRQLTKE 156 IQLTPQIAKT166 YRCGMKPNTE180 TSDHCSLPED190 LRVLEVSNHW200 WYSMLILPPL 210 LKDSVAAPLL220 SAYYPDCVGM230 SPSCTSTNRH261 VPGMNRYFQP271 FYQPNECGKA 281 LCVRPDVMEL291 DELYEFPEYS301 RDPTMYLALR311 NLILALWYTN321 CKEALTPQKC 331 IPHIIVRGLV341 RIRCVQEVER351 ILYFMTRKGL361 INTGVLSVGA371 DQYLLPKDYH 381 NKSVIIIGAG391 PAGLAAARQL401 HNFGIKVTVL411 EAKDRIGGRV421 WDDKSFKGVT 431 VGRGAQIVNG441 CINNPVALMC451 EQLGISMHKF461 GERCDLIQEG471 GRITDPTIDK 481 RMDFHFNALL491 DVVSEWRKDK501 TQLQDVPLGE511 KIEEIYKAFI521 KESGIQFSEL 531 EGQVLQFHLS541 NLEYACGSNL551 HQVSARSWDH561 NEFFAQFAGD571 HTLLTPGYSV 581 IIEKLAEGLD591 IQLKSPVQCI601 DYSGDEVQVT611 TTDGTGYSAQ621 KVLVTVPLAL 631 LQKGAIQFNP641 PLSEKKMKAI651 NSLGAGIIEK661 IALQFPYRFW671 DSKVQGADFF 681 GHVPPSASKR691 GLFAVFYDMD701 PQKKHSVLMS711 VIAGEAVASV721 RTLDDKQVLQ 731 QCMATLRELF741 KEQEVPDPTK751 YFVTRWSTDP761 WIQMAYSFVK771 TGGSGEAYDI 781 IAEDIQGTVF791 FAGEATNRHF801 PQTVTGAYLS811 GVREASKIAA821 F |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:660 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.516
GLY389
3.277
ALA390
4.050
GLY391
3.544
PRO392
3.264
ALA393
2.906
GLY394
4.176
LEU411
3.535
GLU412
2.580
ALA413
2.954
LYS414
3.260
GLY418
3.565
GLY419
3.230
ARG420
2.477
VAL421
4.138
ARG434
3.640
GLY435
3.618
ALA436
3.385
GLN437
2.931
ILE438
2.693
ASN440
4.548
TYR579
3.677
SER596
4.028
PRO597
3.619
VAL598
2.874
THR626
3.596
VAL627
3.319
PRO628
3.356
LEU631
4.226
ILE637
3.574
ILE659
3.686
GLU660
4.998
LYS661
4.220
TRP757
3.598
TRP762
3.285
ILE763
4.236
MET765
4.237
ALA766
3.587
TYR767
3.817
GLY794
3.068
GLU795
2.914
GLN803
2.477
THR804
3.248
VAL805
2.830
THR806
4.405
ALA808
3.302
|
|||||
| PDB ID: 7XE1 Crystal structure of LSD2 in complex with cis-4-Br-PCPA | ||||||
| Method | X-ray diffraction | Resolution | 2.07 Å | Mutation | No | [2] |
| PDB Sequence |
EKKYRKCEKA
56 GCTATCPVCF66 ASASERCAKN76 GYTSRWYHLS86 CGEHFCNECF96 DHYYRSHKDG 106 YDKYTTWKKI116 WTSNGKTEPS126 PKAFMADQQL136 PYWVQCTKPE146 CRKWRQLTKE 156 IQLTPQIAKT166 YRCGMKPNTE180 TSDHCSLPED190 LRVLEVSNHW200 WYSMLILPPL 210 LKDSVAAPLL220 SAYYPDCVGM230 SPSCTSTNRH261 VPGMNRYFQP271 FYQPNECGKA 281 LCVRPDVMEL291 DELYEFPEYS301 RDPTMYLALR311 NLILALWYTN321 CKEALTPQKC 331 IPHIIVRGLV341 RIRCVQEVER351 ILYFMTRKGL361 INTGVLSVGA371 DQYLLPKDYH 381 NKSVIIIGAG391 PAGLAAARQL401 HNFGIKVTVL411 EAKDRIGGRV421 WDDKSFKGVT 431 VGRGAQIVNG441 CINNPVALMC451 EQLGISMHKF461 GERCDLIQEG471 GRITDPTIDK 481 RMDFHFNALL491 DVVSEWRKDK501 TQLQDVPLGE511 KIEEIYKAFI521 KESGIQFSEL 531 EGQVLQFHLS541 NLEYACGSNL551 HQVSARSWDH561 NEFFAQFAGD571 HTLLTPGYSV 581 IIEKLAEGLD591 IQLKSPVQCI601 DYSGDEVQVT611 TTDGTGYSAQ621 KVLVTVPLAL 631 LQKGAIQFNP641 PLSEKKMKAI651 NSLGAGIIEK661 IALQFPYRFW671 DSKVQGADFF 681 GHVPPSASKR691 GLFAVFYDMD701 PQKKHSVLMS711 VIAGEAVASV721 RTLDDKQVLQ 731 QCMATLRELF741 KEQEVPDPTK751 YFVTRWSTDP761 WIQMAYSFVK771 TGGSGEAYDI 781 IAEDIQGTVF791 FAGEATNRHF801 PQTVTGAYLS811 GVREASKIAA821 F |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.506
GLY389
3.253
ALA390
4.080
GLY391
3.479
PRO392
3.265
ALA393
2.939
GLY394
4.272
LEU411
3.522
GLU412
2.610
ALA413
3.024
LYS414
3.445
GLY418
3.692
GLY419
3.251
ARG420
2.584
VAL421
4.176
ARG434
3.659
GLY435
3.655
ALA436
3.363
GLN437
2.920
ILE438
2.754
TYR579
3.799
SER596
4.101
PRO597
3.649
VAL598
2.870
THR626
3.620
VAL627
3.308
PRO628
3.462
LEU631
4.237
ILE637
3.636
ILE659
3.786
LYS661
4.257
TRP757
3.605
TRP762
3.323
ILE763
3.671
MET765
4.196
ALA766
3.654
TYR767
3.864
GLY794
3.085
GLU795
2.953
GLN803
2.523
THR804
3.307
VAL805
2.825
THR806
4.421
ALA808
3.302
|
|||||
| PDB ID: 7XE3 Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) | ||||||
| Method | X-ray diffraction | Resolution | 2.82 Å | Mutation | No | [2] |
| PDB Sequence |
SEKKYRKCEK
55 AGCTATCPVC65 FASASERCAK75 NGYTSRWYHL85 SCGEHFCNEC95 FDHYYRSHKD 105 GYDKYTTWKK115 IWTSNGKTEP125 SPKAFMADQQ135 LPYWVQCTKP145 ECRKWRQLTK 155 EIQLTPQIAK165 TYRCGMKPNT175 TSDHCSLPED190 LRVLEVSNHW200 WYSMLILPPL 210 LKDSVAAPLL220 SAYYPDCVGM230 SPSCTSVPGM265 NRYFQPFYQP275 NECGKALCVR 285 PDVMELDELY295 EFPEYSRDPT305 MYLALRNLIL315 ALWYTNCKEA325 LTPQKCIPHI 335 IVRGLVRIRC345 VQEVERILYF355 MTRKGLINTG365 VLSVGADQYL375 LPKDYHNKSV 385 IIIGAGPAGL395 AAARQLHNFG405 IKVTVLEAKD415 RIGGRVWDDK425 SFKGVTVGRG 435 AQIVNGCINN445 PVALMCEQLG455 ISMHKFGERC465 DLIQEGGRIT475 DPTIDKRMDF 485 HFNALLDVVS495 EWRKDKTQLQ505 DVPLGEKIEE515 IYKAFIKESG525 IQFSELEGQV 535 LQFHLSNLEY545 ACGSNLHQVS555 ARSWDHNEFF565 AQFAGDHTLL575 TPGYSVIIEK 585 LAEGLDIQLK595 SPVQCIDYSG605 DEVQVTTTDG615 TGYSAQKVLV625 TVPLALLQKG 635 AIQFNPPLSE645 KKMKAINSLG655 AGIIEKIALQ665 FPYRFWDSKV675 QGADFFGHVP 685 PSASKRGLFA695 VFYDMDPQKK705 HSVLMSVIAG715 EAVASVRTLD725 DKQVLQQCMA 735 TLRELFKEQE745 VPDPTKYFVT755 RWSTDPWIQM765 AYSFVKTGGS775 GEAYDIIAED 785 IQGTVFFAGE795 ATNRHFPQTV805 TGAYLSGVRE815 ASKIAAF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.559
GLY389
3.171
ALA390
4.047
GLY391
3.509
PRO392
3.168
ALA393
2.996
GLY394
4.236
LEU411
3.670
GLU412
2.462
ALA413
3.027
LYS414
3.334
GLY418
3.734
GLY419
3.313
ARG420
2.545
VAL421
4.511
ARG434
3.533
GLY435
3.713
ALA436
3.304
GLN437
3.165
ILE438
2.769
TYR579
3.815
SER596
4.125
PRO597
3.763
VAL598
2.925
THR626
3.636
VAL627
3.218
PRO628
3.483
LEU631
4.026
ILE637
3.410
ILE659
3.826
LYS661
4.142
TRP757
3.506
TRP762
3.208
ILE763
4.209
MET765
4.036
ALA766
3.374
TYR767
3.789
GLY794
3.052
GLU795
2.979
GLN803
2.265
THR804
3.165
VAL805
2.673
THR806
4.260
ALA808
3.402
|
|||||
| PDB ID: 4GU1 Crystal structure of LSD2 | ||||||
| Method | X-ray diffraction | Resolution | 2.94 Å | Mutation | No | [3] |
| PDB Sequence |
PLGSEFKGLR
48 RRRKCEKAGC58 TATCPVCFAS68 ASERCAKNGY78 TSRWYHLSCG88 EHFCNECFDH 98 YYRSHKDGYD108 KYTTWKKIWT118 SNGKTEPSPK128 AFMADQQLPY138 WVQCTKPECR 148 KWRQLTKEIQ158 LTPQIAKTYR168 CGMKTSDHCS186 LPEDLRVLEV196 SNHWWYSMLI 206 LPPLLKDSVA216 APLLSAYYPD226 CVGMSPSCGM265 NRYFQPFYQP275 NECGKALCVR 285 PDVMELDELY295 EFPEYSRDPT305 MYLALRNLIL315 ALWYTNCKEA325 LTPQKCIPHI 335 IVRGLVRIRC345 VQEVERILYF355 MTRKGLINTG365 VLSVGADQYL375 LPKDYHNKSV 385 IIIGAGPAGL395 AAARQLHNFG405 IKVTVLEAKD415 RIGGRVWDDK425 SFKGVTVGRG 435 AQIVNGCINN445 PVALMCEQLG455 ISMHKFGERC465 DLIQEGGRIT475 DPTIDKRMDF 485 HFNALLDVVS495 EWRKDKTQLQ505 DVPLGEKIEE515 IYKAFIKESG525 IQFSELEGQV 535 LQFHLSNLEY545 ACGSNLHQVS555 ARSWDHNEFF565 AQFAGDHTLL575 TPGYSVIIEK 585 LAEGLDIQLK595 SPVQCIDYSG605 DEVQVTTTDG615 TGYSAQKVLV625 TVPLALLQKG 635 AIQFNPPLSE645 KKMKAINSLG655 AGIIEKIALQ665 FPYRFWDSKV675 QGADFFGHVP 685 PSASKRGLFA695 VFYDMDPQKK705 HSVLMSVIAG715 EAVASVRTLD725 DKQVLQQCMA 735 TLRELFKEQE745 VPDPTKYFVT755 RWSTDPWIQM765 AYSFVKTGGS775 GEAYDIIAED 785 IQGTVFFAGE795 ATNRHFPQTV805 TGAYLSGVRE815 ASKIAA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:416 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:545 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:636 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.458
GLY389
3.669
ALA390
4.236
GLY391
3.553
PRO392
3.138
ALA393
2.860
GLY394
4.188
LEU411
3.610
GLU412
2.100
ALA413
3.098
LYS414
3.165
ARG416
4.913
GLY418
3.928
GLY419
3.342
ARG420
2.544
VAL421
4.289
ARG434
3.429
GLY435
3.297
ALA436
3.324
GLN437
3.646
ILE438
3.253
ASN440
4.623
TYR545
4.919
TYR579
3.752
SER596
4.404
PRO597
3.505
VAL598
2.921
THR626
3.614
VAL627
3.250
PRO628
3.656
LEU631
4.318
ALA636
4.832
ILE637
3.943
ILE659
3.945
LYS661
4.332
TRP757
3.581
TRP762
3.257
ILE763
4.465
MET765
4.091
ALA766
3.643
TYR767
4.041
GLY794
3.173
GLU795
2.725
GLN803
2.363
THR804
3.369
VAL805
2.755
THR806
4.451
ALA808
3.708
|
|||||
| PDB ID: 4HSU Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | Yes | [4] |
| PDB Sequence |
GSRKCEKAGC
58 TATCPVCFAS68 ASERCAKNGY78 TSRWYHLSCG88 EHFCNECFDH98 YYRSHKDGYD 108 KYTTWKKIWT118 SNGKTEPSPK128 AFMADQQLPY138 WVQCTKPECR148 KWRQLTKEIQ 158 LTPQIAKTYR168 CGMKSDHCSL187 PEDLRVLEVS197 NHWWYSMLIL207 PPLLKDSVAA 217 PLLSAYYPDC227 VGMSPSCTGM265 NRYFQPFYQP275 NECGKALCVR285 PDVMELDELY 295 EFPEYSRDPT305 MYLALRNLIL315 ALWYTNCKEA325 LTPQKCIPHI335 IVRGLVRIRC 345 VQEVERILYF355 MTRKGLINTG365 VLSVGADQYL375 LPKDYHNKSV385 IIIGAGPAGL 395 AAARQLHNFG405 IKVTVLEAKD415 RIGGRVWDDK425 SFKGVTVGRG435 AQIVNGCINN 445 PVALMCEQLG455 ISMHKFGERC465 DLIQEGGRIT475 DPTIDKRMDF485 HFNALLDVVS 495 EWRKDKTQLQ505 DVPLGEKIEE515 IYKAFIKESG525 IQFSELEGQV535 LQFHLSNLEY 545 ACGSNLHQVS555 ARSWDHNEFF565 AQFAGDHTLL575 TPGYSVIIEK585 LAEGLDIQLK 595 SPVQCIDYSG605 DEVQVTTTDG615 TGYSAQKVLV625 TVPLALLQKG635 AIQFNPPLSE 645 KKMKAINSLG655 AGIIEKIALQ665 FPYRFWDSKV675 QGADFFGHVP685 PSASKRGLFA 695 VFYDMDPQKK705 HSVLMSVIAG715 EAVASVRTLD725 DKQVLQQCMA735 TLRELFKEQE 745 VPDPTKYFVT755 RWSTDPWIQM765 AYSFVKTGGS775 GEAYDIIAED785 IQGTVFFAGE 795 ATNRHFPQTV805 TGAYLSGVRE815 ASKIAAF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:416 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:545 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.605
GLY389
3.374
ALA390
3.787
GLY391
3.608
PRO392
3.243
ALA393
2.901
GLY394
4.476
LEU411
3.381
GLU412
2.267
ALA413
3.146
LYS414
3.266
ARG416
4.954
GLY418
3.869
GLY419
3.556
ARG420
2.700
VAL421
4.304
ARG434
3.513
GLY435
3.583
ALA436
3.250
GLN437
3.707
ILE438
3.068
ASN440
4.049
TYR545
4.915
TYR579
3.898
SER596
4.084
PRO597
3.743
VAL598
3.143
THR626
3.815
VAL627
3.399
PRO628
3.550
LEU631
4.294
ILE637
4.204
ILE659
3.864
LYS661
4.088
TRP757
3.532
TRP762
3.228
ILE763
4.289
MET765
4.078
ALA766
3.602
TYR767
3.732
GLY794
3.294
GLU795
3.299
GLN803
2.372
THR804
3.443
VAL805
3.044
THR806
4.726
ALA808
3.232
|
|||||
| PDB ID: 4GUT Crystal structure of LSD2-NPAC | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [3] |
| PDB Sequence |
PLGSRKCEKA
56 GCTATCPVCF66 ASASERCAKN76 GYTSRWYHLS86 CGEHFCNECF96 DHYYRSHKDG 106 YDKYTTWKKI116 WTSNGKTEPS126 PKAFMADQQL136 PYWVQCTKPE146 CRKWRQLTKE 156 IQLTPQIAKT166 YRCGMKPNSD183 HCSLPEDLRV193 LEVSNHWWYS203 MLILPPLLKD 213 SVAAPLLSAY223 YPDCVGMSPS233 CTGMNRYFQP271 FYQPNECGKA281 LCVRPDVMEL 291 DELYEFPEYS301 RDPTMYLALR311 NLILALWYTN321 CKEALTPQKC331 IPHIIVRGLV 341 RIRCVQEVER351 ILYFMTRKGL361 INTGVLSVGA371 DQYLLPKDYH381 NKSVIIIGAG 391 PAGLAAARQL401 HNFGIKVTVL411 EAKDRIGGRV421 WDDKSFKGVT431 VGRGAQIVNG 441 CINNPVALMC451 EQLGISMHKF461 GERCDLIQEG471 GRITDPTIDK481 RMDFHFNALL 491 DVVSEWRKDK501 TQLQDVPLGE511 KIEEIYKAFI521 KESGIQFSEL531 EGQVLQFHLS 541 NLEYACGSNL551 HQVSARSWDH561 NEFFAQFAGD571 HTLLTPGYSV581 IIEKLAEGLD 591 IQLKSPVQCI601 DYSGDEVQVT611 TTDGTGYSAQ621 KVLVTVPLAL631 LQKGAIQFNP 641 PLSEKKMKAI651 NSLGAGIIEK661 IALQFPYRFW671 DSKVQGADFF681 GHVPPSASKR 691 GLFAVFYDMD701 PQKKHSVLMS711 VIAGEAVASV721 RTLDDKQVLQ731 QCMATLRELF 741 KEQEVPDPTK751 YFVTRWSTDP761 WIQMAYSFVK771 TGGSGEAYDI781 IAEDIQGTVF 791 FAGEATNRHF801 PQTVTGAYLS811 GVREASKIAA821
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.601
GLY389
3.589
ALA390
4.117
GLY391
3.440
PRO392
3.349
ALA393
2.972
GLY394
4.395
LEU411
3.563
GLU412
2.584
ALA413
3.178
LYS414
3.344
GLY418
3.810
GLY419
3.219
ARG420
2.784
VAL421
4.254
ARG434
3.495
GLY435
3.473
ALA436
3.278
GLN437
3.208
ILE438
2.904
ASN440
4.294
TYR579
3.778
SER596
4.043
PRO597
3.742
VAL598
2.952
THR626
3.715
VAL627
3.232
PRO628
3.567
LEU631
4.195
ILE637
3.660
ILE659
3.877
LYS661
4.107
TRP757
3.523
TRP762
3.382
ILE763
3.749
MET765
4.118
ALA766
3.380
TYR767
3.868
GLY794
3.205
GLU795
3.127
GLN803
2.412
THR804
3.343
VAL805
2.941
THR806
4.471
ALA808
3.266
|
|||||
| PDB ID: 4GUS Crystal structure of LSD2-NPAC with H3 in space group P3221 | ||||||
| Method | X-ray diffraction | Resolution | 2.23 Å | Mutation | Yes | [3] |
| PDB Sequence |
GSRKCEKAGC
58 TATCPVCFAS68 ASERCAKNGY78 TSRWYHLSCG88 EHFCNECFDH98 YYRSHKDGYD 108 KYTTWKKIWT118 SNGKTEPSPK128 AFMADQQLPY138 WVQCTKPECR148 KWRQLTKEIQ 158 LTPQIAKTYR168 CGMKPNTAIK178 PETSDHCSLP188 EDLRVLEVSN198 HWWYSMLILP 208 PLLKDSVAAP218 LLSAYYPDCV228 GMSPSCTGMN266 RYFQPFYQPN276 ECGKALCVRP 286 DVMELDELYE296 FPEYSRDPTM306 YLALRNLILA316 LWYTNCKEAL326 TPQKCIPHII 336 VRGLVRIRCV346 QEVERILYFM356 TRKGLINTGV366 LSVGADQYLL376 PKDYHNKSVI 386 IIGAGPAGLA396 AARQLHNFGI406 KVTVLEAKDR416 IGGRVWDDKS426 FKGVTVGRGA 436 QIVNGCINNP446 VALMCEQLGI456 SMHKFGERCD466 LIQEGGRITD476 PTIDKRMDFH 486 FNALLDVVSE496 WRKDKTQLQD506 VPLGEKIEEI516 YKAFIKESGI526 QFSELEGQVL 536 QFHLSNLEYA546 CGSNLHQVSA556 RSWDHNEFFA566 QFAGDHTLLT576 PGYSVIIEKL 586 AEGLDIQLKS596 PVQCIDYSGD606 EVQVTTTDGT616 GYSAQKVLVT626 VPLALLQKGA 636 IQFNPPLSEK646 KMKAINSLGA656 GIIEKIALQF666 PYRFWDSKVQ676 GADFFGHVPP 686 SASKRGLFAV696 FYDMDPQKKH706 SVLMSVIAGE716 AVASVRTLDD726 KQVLQQCMAT 736 LRELFKEQEV746 PDPTKYFVTR756 WSTDPWIQMA766 YSFVKTGGSG776 EAYDIIAEDI 786 QGTVFFAGEA796 TNRHFPQTVT806 GAYLSGVREA816 SKIAAF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:660 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.440
GLY389
3.379
ALA390
4.003
GLY391
3.321
PRO392
3.325
ALA393
2.964
GLY394
4.180
LEU411
3.275
GLU412
2.710
ALA413
3.128
LYS414
3.519
GLY418
3.705
GLY419
3.239
ARG420
2.774
VAL421
4.249
ARG434
3.700
GLY435
3.512
ALA436
3.181
GLN437
3.499
ILE438
3.054
ASN440
3.927
TYR579
3.918
SER596
4.166
PRO597
3.840
VAL598
3.119
THR626
3.876
VAL627
3.485
PRO628
3.500
LEU631
4.118
ILE637
3.772
ILE659
3.670
GLU660
4.834
LYS661
4.024
TRP757
3.672
TRP762
3.087
ILE763
4.195
MET765
4.095
ALA766
3.411
TYR767
3.888
GLY794
3.103
GLU795
2.968
GLN803
2.392
THR804
3.180
VAL805
2.971
THR806
4.499
ALA808
3.253
|
|||||
| PDB ID: 4GUR Crystal structure of LSD2-NPAC with H3 in space group P21 | ||||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | Yes | [3] |
| PDB Sequence |
RKCEKAGCTA
60 TCPVCFASAS70 ERCAKNGYTS80 RWYHLSCGEH90 FCNECFDHYY100 RSHKDGYDKY 110 TTWKKIWTSN120 GKTEPSPKAF130 MADQQLPYWV140 QCTKPECRKW150 RQLTKEIQLT 160 PQIAKTYRCG170 MSDHCSLPED190 LRVLEVSNHW200 WYSMLILPPL210 LKDSVAAPLL 220 SAYYPDCVGM230 SPSCTGMNRY268 FQPFYQPNEC278 GKALCVRPDV288 MELDELYEFP 298 EYSRDPTMYL308 ALRNLILALW318 YTNCKEALTP328 QKCIPHIIVR338 GLVRIRCVQE 348 VERILYFMTR358 KGLINTGVLS368 VGADQYLLPK378 DYHNKSVIII388 GAGPAGLAAA 398 RQLHNFGIKV408 TVLEAKDRIG418 GRVWDDKSFK428 GVTVGRGAQI438 VNGCINNPVA 448 LMCEQLGISM458 HKFGERCDLI468 QEGGRITDPT478 IDKRMDFHFN488 ALLDVVSEWR 498 KDKTQLQDVP508 LGEKIEEIYK518 AFIKESGIQF528 SELEGQVLQF538 HLSNLEYACG 548 SNLHQVSARS558 WDHNEFFAQF568 AGDHTLLTPG578 YSVIIEKLAE588 GLDIQLKSPV 598 QCIDYSGDEV608 QVTTTDGTGY618 SAQKVLVTVP628 LALLQKGAIQ638 FNPPLSEKKM 648 KAINSLGAGI658 IEKIALQFPY668 RFWDSKVQGA678 DFFGHVPPSA688 SKRGLFAVFY 698 DMDPQKKHSV708 LMSVIAGEAV718 ASVRTLDDKQ728 VLQQCMATLR738 ELFKEQEVPD 748 PTKYFVTRWS758 TDPWIQMAYS768 FVKTGGSGEA778 YDIIAEDIQG788 TVFFAGEATN 798 RHFPQTVTGA808 YLSGVREASK818 IAAF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.463
GLY389
3.364
ALA390
3.725
GLY391
3.710
PRO392
3.380
ALA393
3.016
GLY394
4.523
LEU411
3.402
GLU412
2.174
ALA413
3.243
LYS414
3.512
GLY418
3.998
GLY419
3.619
ARG420
2.812
VAL421
4.392
ARG434
3.461
GLY435
3.566
ALA436
3.437
GLN437
3.617
ILE438
3.232
ASN440
4.119
TYR579
3.836
SER596
4.163
PRO597
3.741
VAL598
3.022
THR626
3.777
VAL627
3.363
PRO628
3.466
LEU631
4.283
ILE637
4.211
ILE659
3.839
LYS661
4.168
TRP757
3.493
TRP762
3.337
ILE763
4.461
MET765
4.120
ALA766
3.553
TYR767
3.887
GLY794
3.201
GLU795
3.346
GLN803
2.368
THR804
3.367
VAL805
2.942
THR806
4.651
ALA808
3.226
|
|||||
| PDB ID: 4GU0 Crystal structure of LSD2 with H3 | ||||||
| Method | X-ray diffraction | Resolution | 3.10 Å | Mutation | Yes | [4] |
| PDB Sequence |
PLGSRKCEKA
56 GCTATCPVCF66 ASASERCAKN76 GYTSRWYHLS86 CGEHFCNECF96 DHYYRSHKDG 106 YDKYTTWKKI116 WTSNGKTEPS126 PKAFMADQQL136 PYWVQCTKPE146 CRKWRQLTKE 156 IQLTPQIAKT166 YRCGMKPNTA176 IKPETSDHCS186 LPEDLRVLEV196 SNHWWYSMLI 206 LPPLLKDSVA216 APLLSAYYPD226 CVGMSPSCTG264 MNRYFQPFYQ274 PNECGKALCV 284 RPDVMELDEL294 YEFPEYSRDP304 TMYLALRNLI314 LALWYTNCKE324 ALTPQKCIPH 334 IIVRGLVRIR344 CVQEVERILY354 FMTRKGLINT364 GVLSVGADQY374 LLPKDYHNKS 384 VIIIGAGPAG394 LAAARQLHNF404 GIKVTVLEAK414 DRIGGRVWDD424 KSFKGVTVGR 434 GAQIVNGCIN444 NPVALMCEQL454 GISMHKFGER464 CDLIQEGGRI474 TDPTIDKRMD 484 FHFNALLDVV494 SEWRKDKTQL504 QDVPLGEKIE514 EIYKAFIKES524 GIQFSELEGQ 534 VLQFHLSNLE544 YACGSNLHQV554 SARSWDHNEF564 FAQFAGDHTL574 LTPGYSVIIE 584 KLAEGLDIQL594 KSPVQCIDYS604 GDEVQVTTTD614 GTGYSAQKVL624 VTVPLALLQK 634 GAIQFNPPLS644 EKKMKAINSL654 GAGIIEKIAL664 QFPYRFWDSK674 VQGADFFGHV 684 PPSASKRGLF694 AVFYDMDPQK704 KHSVLMSVIA714 GEAVASVRTL724 DDKQVLQQCM 734 ATLRELFKEQ744 EVPDPTKYFV754 TRWSTDPWIQ764 MAYSFVKTGG774 SGEAYDIIAE 784 DIQGTVFFAG794 EATNRHFPQT804 VTGAYLSGVR814 EASKIAAF
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FAD or .FAD2 or .FAD3 or :3FAD;style chemicals stick;color identity;select .A:388 or .A:389 or .A:390 or .A:391 or .A:392 or .A:393 or .A:394 or .A:411 or .A:412 or .A:413 or .A:414 or .A:418 or .A:419 or .A:420 or .A:421 or .A:434 or .A:435 or .A:436 or .A:437 or .A:438 or .A:440 or .A:579 or .A:596 or .A:597 or .A:598 or .A:626 or .A:627 or .A:628 or .A:631 or .A:637 or .A:659 or .A:661 or .A:757 or .A:762 or .A:763 or .A:765 or .A:766 or .A:767 or .A:794 or .A:795 or .A:803 or .A:804 or .A:805 or .A:806 or .A:808; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE388
3.682
GLY389
3.362
ALA390
3.782
GLY391
3.790
PRO392
3.357
ALA393
3.022
GLY394
4.564
LEU411
3.416
GLU412
2.415
ALA413
3.167
LYS414
3.570
GLY418
3.863
GLY419
3.666
ARG420
2.707
VAL421
4.348
ARG434
3.427
GLY435
3.321
ALA436
3.307
GLN437
3.655
ILE438
3.143
ASN440
4.111
TYR579
4.033
SER596
4.400
PRO597
3.639
VAL598
3.202
THR626
3.806
VAL627
3.598
PRO628
3.599
LEU631
4.201
ILE637
4.304
ILE659
4.250
LYS661
3.872
TRP757
3.595
TRP762
3.004
ILE763
4.341
MET765
4.200
ALA766
3.831
TYR767
3.766
GLY794
3.244
GLU795
3.415
GLN803
2.346
THR804
3.321
VAL805
2.762
THR806
4.587
ALA808
3.227
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. Cell Res. 2013 Feb;23(2):225-41. | ||||
| REF 2 | Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. doi:10.1021/acsmedchemlett.2c00294. | ||||
| REF 3 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell. 2013 Feb 7;49(3):558-70. | ||||
| REF 4 | Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res. 2013 Feb;23(2):306-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.