Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28330 | Target Info | |||
| Target Name | Cholecystokinin receptor type A (CCKAR) | ||||
| Synonyms | CCKAR; CCK-AR; CCK-A receptor | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CCKAR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7MBY Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex | ||||||
| Method | Electron microscopy | Resolution | 2.44 Å | Mutation | Yes | [1] |
| PDB Sequence |
EWQPAVQILL
47 YSLIFLLSVL57 GNTLVITVLI67 RNKRMRTVTN77 IFLLSLAVSD87 LMLCLFCMPF 97 NLIPNLLKDF107 IFGSAVCKTT117 TYFMGTSVSV127 STFNLVAISL137 ERYGAICKPL 147 QSRVWQTKSH157 ALKVIAATWC167 LSFTIMTPYP177 IYSNLVPFTK187 NNNQTANMCR 197 FLLPNDVMQQ207 SWHTFLLLIL217 FLIPGIVMMV227 AYGLISLELY237 QLMAKKRVIR 313 MLIVIVVLFF323 LCWMPIFSAN333 AWRAYDTASA343 ERRLSGTPIS353 FILLLSYTSS 363 CVNPIIYCFM373 NKRFRLGFMA383 TFP
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| PDB ID: 7MBX Human Cholecystokinin 1 receptor (CCK1R) Gs complex | ||||||
| Method | Electron microscopy | Resolution | 1.95 Å | Mutation | Yes | [1] |
| PDB Sequence |
EWQPAVQILL
47 YSLIFLLSVL57 GNTLVITVLI67 RNKRMRTVTN77 IFLLSLAVSD87 LMLCLFCMPF 97 NLIPNLLKDF107 IFGSAVCKTT117 TYFMGTSVSV127 STFNLVAISL137 ERYGAICKPL 147 QSRVWQTKSH157 ALKVIAATWC167 LSFTIMTPYP177 IYSNLVPFTK187 NNNQTANMCR 197 FLLPNDVMQQ207 SWHTFLLLIL217 FLIPGIVMMV227 AYGLISLELY237 QGIKFESAAN 304 LMAKKRVIRM314 LIVIVVLFFL324 CWMPIFSANA334 WRAYDTASAE344 RRLSGTPISF 354 ILLLSYTSSC364 VNPIIYCFMN374 KRFRLGFMAT384 FP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLoS Biol. 2021 Jun 4;19(6):e3001295. | ||||
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