Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30286 | Target Info | |||
| Target Name | Hyperpolarization cyclic nucleotide-gated channel 4 (HCN4) | ||||
| Synonyms | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HCN4 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCCCCCCCCCCC | ||||
| InChI | 1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1 | ||||
| InChIKey | LVNGJLRDBYCPGB-LDLOPFEMSA-N | ||||
| PubChem Compound ID | 447078 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6GYN Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
MQRQFGAMLQ
223 PGVNKFSLRM233 FGSQKAVERE243 QERVKSAGFW253 IIHPYSDFRF263 YWDLTMLLLM 273 VGNLIIIPVG283 ITFFKDENTT293 PWIVFNVVSD303 TFFLIDLVLN313 FRTGIVVEDN 323 TEIILDPQRI333 KMKYLKSWFM343 VDFISSIPVD353 YIFLIVETRI363 DSEVYKTARA 373 LRIVRFTKIL383 SLLRLLRLSR393 LIRYIHQWEE403 IFHMTYDLAS413 AVVRIVNLIG 423 MMLLLCHWDG433 CLQFLVPMLQ443 DFPDDCWVSI453 NNMVNNSWGK463 QYSYALFKAM 473 SHMLCIGYGR483 QAPVGMSDVW493 LTMLSMIVGA503 TCYAMFIGHA513 TALIQSLDSS 523 RRQYQEKYKQ533 VEQYMSFHKL543 PPDTRQRIHD553 YYEHRYQGKM563 FDEESILGEL 573 SEPLREEIIN583 FNCRKLVASM593 PLFANADPNF603 VTSMLTKLRF613 EVFQPGDYII 623 REGTIGKKMY633 FIQHGVVSVL643 TKGNKETKLA653 DGSYFGEICL663 LTRGRRTASV 673 RADTYCRLYS683 LSVDNFNEVL693 EEYPMMRRAF703 ETVAL
|
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|
|
VAL274
3.970
ILE278
4.127
ILE279
3.716
VAL282
3.690
GLY283
4.072
PHE287
3.155
ASP289
4.044
GLU290
4.067
THR292
2.686
PRO294
4.488
TRP295
3.543
PHE298
4.320
LEU394
3.856
ILE395
4.168
ILE398
3.761
HIS399
3.076
ARG417
4.020
ASN420
3.374
|
|||||
| PDB ID: 6GYO Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [2] |
| PDB Sequence |
MQRQFGAMLQ
223 PGVNKFSLRM233 FGSQKAVERE243 QERVKSAGFW253 IIHPYSDFRF263 YWDLTMLLLM 273 VGNLIIIPVG283 ITFFKDENTT293 PWIVFNVVSD303 TFFLIDLVLN313 FRTGIVVEDN 323 TEIILDPQRI333 KMKYLKSWFM343 VDFISSIPVD353 YIFLIVETRI363 DSEVYKTARA 373 LRIVRFTKIL383 SLLRLLRLSR393 LIRYIHQWEE403 IFHMTYDLAS413 AVVRIVNLIG 423 MMLLLCHWDG433 CLQFLVPMLQ443 DFPDDCWVSI453 NNMVNNSWGK463 QYSYALFKAM 473 SHMLCIGYGR483 QAPVGMSDVW493 LTMLSMIVGA503 TCYAMFIGHA513 TALIQSLDSS 523 RRQYQEKYKQ533 VEQYMSFHKL543 PPDTRQRIHD553 YYEHRYQGKM563 FDEESILGEL 573 SEPLREEIIN583 FNCRKLVASM593 PLFANADPNF603 VTSMLTKLRF613 EVFQPGDYII 623 REGTIGKKMY633 FIQHGVVSVL643 TKGNKETKLA653 DGSYFGEICL663 LTRGRRTASV 673 RADTYCRLYS683 LSVDNFNEVL693 EEYPMMRRAF703 ETVALDRLDR713 I |
|||||
|
|
LEU271
3.380
LEU272
4.464
VAL274
3.732
GLY275
3.901
ILE278
3.792
ILE279
3.768
VAL282
3.734
GLY283
3.849
PHE287
3.202
ASP289
3.741
GLU290
3.318
ASN291
4.410
THR292
2.407
PRO294
4.220
TRP295
3.629
PHE298
3.660
LEU391
4.825
LEU394
3.777
ILE395
3.996
ILE398
3.747
HIS399
3.079
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | ||||
| REF 2 | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | ||||
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