Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T32880 Target Info
Target Name HIF-prolyl hydroxylase 2 (HPH-2)
Synonyms SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12
Target Type Patented-recorded Target
Gene Name EGLN1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
EGLN1_HUMAN
Ligand General Information  Top
Ligand Name N-[(4-Hydroxy-8-iodoisoquinolin-3-YL)carbonyl]glycine Ligand Info
Canonical SMILES C1=CC2=C(C(=NC=C2C(=C1)I)C(=O)NCC(=O)O)O
InChI 1S/C12H9IN2O4/c13-8-3-1-2-6-7(8)4-14-10(11(6)18)12(19)15-5-9(16)17/h1-4,18H,5H2,(H,15,19)(H,16,17)
InChIKey FUMNLXHPILGSLC-UHFFFAOYSA-N
PubChem Compound ID 6914624
Drug Binding Sites of Target  Top
PDB ID: 2G1M      Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Method X-ray diffraction Resolution 2.20 Å Mutation No [1]
PDB Sequence
LPALKLALEY
197
IVPCMNKHGI
207
CVVDDFLGKE
217
TGQQIGDEVR
227
ALHDTGKFTD
237

GQLVSSKDIR
252
GDKITWIEGK
262
EPGCETIGLL
272
MSSMDDLIRH
282
CNGKLGSYKI
292

NGRTKAMVAC
302
YPGNGTGYVR
312
HVDNPNGDGR
322
CVTCIYYLNK
332
DWDAKVSGGI
342

LRIFPEGKAQ
352
FADIEPKFDR
362
LLFFWSDRRN
372
PHEVQPAYAT
382
RYAITVWYFD
392

ADERARAKVK
402
Y
Residue
Distance (Å)
ASP254
3.409
ILE256
3.807
MET299
3.328
ALA301
4.505
TYR303
2.733
TYR310
3.498
HIS313
2.747
ASP315
3.497
Residue
Distance (Å)
ILE327
3.874
TYR329
2.430
LEU343
3.474
HIS374
2.769
VAL376
3.302
ARG383
2.812
ALA385
3.955
TRP389
4.474
PDB ID: 2G19      Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Method X-ray diffraction Resolution 1.70 Å Mutation No [1]
PDB Sequence
LPALKLALEY
197
IVPCMNKHGI
207
CVVDDFLGKE
217
TGQQIGDEVR
227
ALHDTGKFTD
237

GQLVSQKSDS
247
SKDIRGDKIT
257
WIEGKEPGCE
267
TIGLLMSSMD
277
DLIRHCNGKL
287

GSYKINGRTK
297
AMVACYPGNG
307
TGYVRHVDNP
317
NGDGRCVTCI
327
YYLNKDWDAK
337

VSGGILRIFP
347
EGKAQFADIE
357
PKFDRLLFFW
367
SDRRNPHEVQ
377
PAYATRYAIT
387

VWYFDADERA
397
RAKVKY
Residue
Distance (Å)
ASP254
3.053
ILE256
3.578
MET299
3.516
ALA301
4.545
TYR303
2.659
TYR310
3.656
HIS313
3.045
ASP315
3.521
Residue
Distance (Å)
ILE327
3.719
TYR329
2.605
LEU343
3.688
HIS374
2.954
VAL376
3.557
ARG383
2.800
ALA385
4.075
TRP389
4.312
References  Top
REF 1 Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.