Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32880 | Target Info | |||
| Target Name | HIF-prolyl hydroxylase 2 (HPH-2) | ||||
| Synonyms | SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | EGLN1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Alpha-ketoglutaric acid | Ligand Info | |||
| Canonical SMILES | C(CC(=O)O)C(=O)C(=O)O | ||||
| InChI | 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) | ||||
| InChIKey | KPGXRSRHYNQIFN-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 51 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5L9B HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574) | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPALKLALEY
197 IVPAMNKHGI207 CVVDDFLGKE217 TGQQIGDEVR227 ALHDTGKFTD237 GQLVSQKSDS 247 SKDIRGDKIT257 WIEGKEPGCE267 TIGLLMSSMD277 DLIRHCNGKL287 GSYKINGRTK 297 AMVACYPGNG307 TGYVRHVDNP317 NGDGRCVTCI327 YYLNKDWDAK337 VSGGILRIFP 347 EGKAQFADIE357 PKFDRLLFFW367 SDRRNPHEVQ377 PAYATRYAIT387 VWYFDADERA 397 AAKVKYLTGE407 KG
|
|||||
|
|
||||||
| PDB ID: 3OUJ PHD2 with 2-Oxoglutarate | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
| PDB Sequence |
GQTKPLPALK
192 LALEYIVPCM202 NKHGICVVDD212 FLGKETGQQI222 GDEVRALHDT232 GKFTDGQLVS 242 QKKDIRGDKI256 TWIEGKEPGC266 ETIGLLMSSM276 DDLIRHCNGK286 LGSYKINGRT 296 KAMVACYPGN306 GTGYVRHVDN316 PNGDGRCVTC326 IYYLNKDWDA336 KVSGGILRIF 346 PEGKAQFADI356 EPKFDRLLFF366 WSDRRNPHEV376 QPAYATRYAI386 TVWYFDADER 396 ARAKVGEKGV410 RVELNK
|
|||||
|
|
||||||
| PDB ID: 7Q5X HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-2 ALPHA CODD (523-542) | ||||||
| Method | X-ray diffraction | Resolution | 1.21 Å | Mutation | No | [3] |
| PDB Sequence |
PLPALKLALE
196 YIVPCMNKHG206 ICVVDDFLGK216 ETGQQIGDEV226 RALHDTGKFT236 DGQLVSQKSD 246 SSKDIRGDKI256 TWIEGKEPGC266 ETIGLLMSSM276 DDLIRHCNGK286 LGSYKINGRT 296 KAMVACYPGN306 GTGYVRHVDN316 PNGDGRCVTC326 IYYLNKDWDA336 KVSGGILRIF 346 PEGKAQFADI356 EPKFDRLLFF366 WSDRRNPHEV376 QPAYATRYAI386 TVWYFDADER 396 ARAKVKYLTG406 E
|
|||||
|
|
||||||
| PDB ID: 6YW1 HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer) | ||||||
| Method | X-ray diffraction | Resolution | 1.46 Å | Mutation | No | [4] |
| PDB Sequence |
KPLPALKLAL
195 EYIVPCMNKH205 GICVVDDFLG215 KETGQQIGDE225 VRALHDTGKF235 TDGQDIRGDK 255 ITWIEGKEPG265 CETIGLLMSS275 MDDLIRHCNG285 KLGSYKINGR295 TKAMVACYPG 305 NGTGYVRHVD315 NPNGDGRCVT325 CIYYLNKDWD335 AKVSGGILRI345 FPEGKAQFAD 355 IEPKFDRLLF365 FWSDRRNPHE375 VQPAYATRYA385 ITVWYFDADE395 RARAKVKYL |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AKG or .AKG2 or .AKG3 or :3AKG;style chemicals stick;color identity;select .A:252 or .A:254 or .A:299 or .A:303 or .A:310 or .A:313 or .A:315 or .A:327 or .A:329 or .A:343 or .A:358 or .A:366 or .A:374 or .A:376 or .A:383 or .A:385 or .A:387 or .A:389; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun. 2016 Aug 26;7:12673. | ||||
| REF 2 | Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Med Chem Lett. 2010 Oct 5;1(9):526-9. | ||||
| REF 3 | HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH 2_OXOGLUTARATE (2OG) AND HIF-2 ALPHA CODD (523-542) | ||||
| REF 4 | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep. 2020 Dec 15;10(1):21964. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.