Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32880 | Target Info | |||
| Target Name | HIF-prolyl hydroxylase 2 (HPH-2) | ||||
| Synonyms | SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | EGLN1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | D-tyrosine | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)O | ||||
| InChI | 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m1/s1 | ||||
| InChIKey | OUYCCCASQSFEME-MRVPVSSYSA-N | ||||
| PubChem Compound ID | 71098 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6YW1 HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer) | ||||||
| Method | X-ray diffraction | Resolution | 1.46 Å | Mutation | No | [1] |
| PDB Sequence |
KPLPALKLAL
195 EYIVPCMNKH205 GICVVDDFLG215 KETGQQIGDE225 VRALHDTGKF235 TDGQDIRGDK 255 ITWIEGKEPG265 CETIGLLMSS275 MDDLIRHCNG285 KLGSYKINGR295 TKAMVACYPG 305 NGTGYVRHVD315 NPNGDGRCVT325 CIYYLNKDWD335 AKVSGGILRI345 FPEGKAQFAD 355 IEPKFDRLLF365 FWSDRRNPHE375 VQPAYATRYA385 ITVWYFDADE395 RARAKVKYL |
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| PDB ID: 6YW4 HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer) | ||||||
| Method | X-ray diffraction | Resolution | 1.53 Å | Mutation | No | [1] |
| PDB Sequence |
KPLPALKLAL
195 EYIVPAMNKH205 GICVVDDFLG215 KETGQQIGDE225 VRALHDTGKF235 TDGQDIRGDK 255 ITWIEGKEPG265 CETIGLLMSS275 MDDLIRHCNG285 KLGSYKINGR295 TKAMVACYPG 305 NGTGYVRHVD315 NPNGDGRCVT325 CIYYLNKDWD335 AKVSGGILRI345 FPEGKAQFAD 355 IEPKFDRLLF365 FWSDRRNPHE375 VQPAYATRYA385 ITVWYFDADE395 RAAAKVKYLT 405
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| PDB ID: 6YW2 HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer) | ||||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [1] |
| PDB Sequence |
TKPLPALKLA
194 LEYIVPCMNK204 HGICVVDDFL214 GKETGQQIGD224 EVRALHDTGK234 FTDGIRGDKI 256 TWIEGKEPGC266 ETIGLLMSSM276 DDLIRHCNGK286 LGSYKINGRT296 KAMVACYPGN 306 GTGYVRHVDN316 PNGDGRCVTC326 IYYLNKDWDA336 KVSGGILRIF346 PEGKAQFADI 356 EPKFDRLLFF366 WSDRRNPHEV376 QPAYATRYAI386 TVWYFDADER396 ARAKVKYLT |
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| PDB ID: 6YW3 HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer) | ||||||
| Method | X-ray diffraction | Resolution | 2.28 Å | Mutation | No | [1] |
| PDB Sequence |
TKPLPALKLA
194 LEYIVPCMNK204 HGICVVDDFL214 GKETGQQIGD224 EVRALHDTGK234 FTDGQLVSQK 244 SDSSKDIRGD254 KITWIEGKEP264 GCETIGLLMS274 SMDDLIRHCN284 GKLGSYKING 294 RTKAMVACYP304 GNGTGYVRHV314 DNPNGDGRCV324 TCIYYLNKDW334 DAKVSGGILR 344 IFPEGKAQFA354 DIEPKFDRLL364 FFWSDRRNPH374 EVQPAYATRY384 AITVWYFDAD 394 ERARAKVKYL404 TGE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep. 2020 Dec 15;10(1):21964. | ||||
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