Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38338 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) | ||||
| Synonyms | Voltage-gated calcium channel alpha subunit Cav2.2; Voltage-dependent N-type calcium channel alpha-1B subunit; N-type Ca2+ channel; Calcium channel, L type, alpha-1 polypeptide isoform 5; CACNA1B; Brain calcium channel III; BIII | ||||
| Target Type | Successful Target | ||||
| Gene Name | CACNA1B | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | Ligand Info | |||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7VFS Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
|
LYS532
3.943
LEU536
4.779
SER544
3.531
SER545
3.257
PHE546
3.093
ASN547
2.932
PHE549
3.908
LEU580
3.722
LEU583
3.766
ARG584
2.914
PHE586
4.537
LYS587
2.871
TRP592
3.326
LEU595
3.612
ARG596
3.256
|
|||||
| PDB ID: 7MIX Human N-type voltage-gated calcium channel Cav2.2 in the presence of ziconotide at 3.0 Angstrom resolution | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [2] |
| PDB Sequence |
KYAKRITEWP
95 PFEYMILATI105 IANCIVLALE115 QHLPDGDKTP125 MSERLDDTEP135 YFIGIFCFEA 145 GIKIIALGFV155 SYLRNGWNVM169 DFVVVLTGIL179 ATAGTDFDLR189 TLRAVRVLRP 199 LKLVSGIPSL209 QVVLKSIMKA219 MVPLLQIGLL229 LFFAILMFAI239 IGLEFYMGKF 249 HKACFPNSTD259 AEPVGDFPCG269 KEAPARLCEG279 DTECREYWPG289 PNFGITNFDN 299 ILFAILTVFQ309 CITMEGWTDI319 LYNTNDAAGN329 TWNWLYFIPL339 IIIGSFFMLN 349 LVLGVLSGEF359 AKERERVENR369 RAFLKLRRQQ379 QIERELNGYL389 EWIFKAEEVM 399 LAEEDRNFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT496 LCVAMVHYNQ 506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF546 NCFDFGVIVG 556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR596 NLVVSLLNSM 606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF646 DTFPAAILTV 656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG696 NYTLLNVFLA 706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAEVSP746 MSAANISIAA 756 RQQNSAKARS766 VWEQRASQLR776 LQNLRASCEA786 LRRFCHYIVT1148 MRYFEVVILV 1158 VIALSSIALA1168 AEDPVRTDSP1178 RNNALKYLDY1188 IFTGVFTFEM1198 VIKMIDLWNI 1221 LDFIVVSGAL1231 VAFAFSGSKG1241 KDINTIKSLR1251 VLRVLRPLKT1261 IKRLPKLKAV 1271 FDCVVNSLKN1281 VLNILIVYML1291 FMFIFAVIAV1301 QLFKGKFFYC1311 TDESKELERD 1321 CRGQYLDYEK1331 EEVEAQPRQW1341 KKYDFHYDNV1351 LWALLTLFTV1361 STGEGWPMVL 1371 KHSVDATYEE1381 QGPSPGYRME1391 LSIFYVVYFV1401 VFPFFFVNIF1411 VALIIITFQE 1421 QGDKVMSECS1431 LEKNERACID1441 FAISAKPLTR1451 YMPQNRQSFQ1461 YKTWTFVVSP 1471 PFEYFIMAMI1481 ALNTVVLMMK1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK 1521 IIAFGVLNYF1531 RDAWNVFDFV1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR 1571 AARLIKLLRQ1581 GYTIRILLWT1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF 1621 GNIALDDDTS1631 INRHNNFRTF1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD 1671 EQANATECGS1681 DFAYFYFVSF1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL 1721 GPHHLDEFIR1731 VWAEYDPAAC1741 GRISYNDMFE1751 MLKHMSPPLG1761 LGKKCPARVA 1771 YKRLVRMNMP1781 ISNEDMTVHF1791 TSTLMALIRT1801 ALEIKLAPAG1811 TKQHQCDAEL 1821 RKEISVVWAN1831 LPQKTL
|
|||||
|
|
ASN386
4.404
SER544
3.150
SER545
2.877
PHE546
2.983
ASN547
4.572
PHE549
4.450
LEU580
4.120
LEU583
3.577
ARG584
2.388
PHE586
4.518
LYS587
2.569
TRP592
2.733
LEU595
3.814
|
|||||
| PDB ID: 7VFU Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
|
VAL479
4.891
LYS480
3.876
LYS532
3.883
SER544
2.708
SER545
3.537
PHE546
3.255
ASN547
3.176
PHE549
4.112
LEU580
4.093
LEU583
3.886
ARG584
3.042
PHE586
4.468
LYS587
2.883
TRP592
3.159
LEU595
3.666
|
|||||
| PDB ID: 7VFV Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PT5 or .PT52 or .PT53 or :3PT5;style chemicals stick;color identity;select .A:386 or .A:480 or .A:532 or .A:544 or .A:545 or .A:546 or .A:547 or .A:549 or .A:580 or .A:583 or .A:584 or .A:587 or .A:592 or .A:595 or .A:596 or .A:598 or .A:599 or .A:602 or .A:606 or .A:609 or .A:613 or .A:704 or .A:707 or .A:1285 or .A:1288 or .A:1292 or .A:1401 or .A:1402 or .A:1406 or .A:1407; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN386
4.714
LYS480
4.451
LYS532
4.644
SER544
3.968
SER545
3.245
PHE546
3.458
ASN547
3.440
PHE549
4.625
LEU580
3.964
LEU583
3.448
ARG584
2.438
LYS587
2.562
TRP592
3.453
LEU595
3.446
ARG596
2.720
|
|||||
| PDB ID: 7MIY Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [2] |
| PDB Sequence |
KYAKRITEWP
95 PFEYMILATI105 IANCIVLALE115 QHLPDGDKTP125 MSERLDDTEP135 YFIGIFCFEA 145 GIKIIALGFV155 SYLRNGWNVM169 DFVVVLTGIL179 ATAGTDFDLR189 TLRAVRVLRP 199 LKLVSGIPSL209 QVVLKSIMKA219 MVPLLQIGLL229 LFFAILMFAI239 IGLEFYMGKF 249 HKACFPNSTD259 AEPVGDFPCG269 KEAPARLCEG279 DTECREYWPG289 PNFGITNFDN 299 ILFAILTVFQ309 CITMEGWTDI319 LYNTNDAAGN329 TWNWLYFIPL339 IIIGSFFMLN 349 LVLGVLSGEF359 AKERERVENR369 RAFLKLRRQQ379 QIERELNGYL389 EWIFKAEEVM 399 LAEEDRNFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT496 LCVAMVHYNQ 506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF546 NCFDFGVIVG 556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR596 NLVVSLLNSM 606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF646 DTFPAAILTV 656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG696 NYTLLNVFLA 706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAEVSP746 MSAANISIAA 756 RQQNSAKARS766 VWEQRASQLR776 LQNLRASCEA786 LRRFCHYIVT1148 MRYFEVVILV 1158 VIALSSIALA1168 AEDPVRTDSP1178 RNNALKYLDY1188 IFTGVFTFEM1198 VIKMIDLWNI 1221 LDFIVVSGAL1231 VAFAFSGSKG1241 KDINTIKSLR1251 VLRVLRPLKT1261 IKRLPKLKAV 1271 FDCVVNSLKN1281 VLNILIVYML1291 FMFIFAVIAV1301 QLFKGKFFYC1311 TDESKELERD 1321 CRGQYLDYEK1331 EEVEAQPRQW1341 KKYDFHYDNV1351 LWALLTLFTV1361 STGEGWPMVL 1371 KHSVDATYEE1381 QGPSPGYRME1391 LSIFYVVYFV1401 VFPFFFVNIF1411 VALIIITFQE 1421 QGDKVMSECS1431 LEKNERACID1441 FAISAKPLTR1451 YMPQNRQSFQ1461 YKTWTFVVSP 1471 PFEYFIMAMI1481 ALNTVVLMMK1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK 1521 IIAFGVLNYF1531 RDAWNVFDFV1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR 1571 AARLIKLLRQ1581 GYTIRILLWT1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF 1621 GNIALDDDTS1631 INRHNNFRTF1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD 1671 EQANATECGS1681 DFAYFYFVSF1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL 1721 GPHHLDEFIR1731 VWAEYDPAAC1741 GRISYNDMFE1751 MLKHMSPPLG1761 LGKKCPARVA 1771 YKRLVRMNMP1781 ISNEDMTVHF1791 TSTLMALIRT1801 ALEIKLAPAG1811 TKQHQCDAEL 1821 RKEISVVWAN1831 LPQKTL
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PT5 or .PT52 or .PT53 or :3PT5;style chemicals stick;color identity;select .A:386 or .A:390 or .A:480 or .A:532 or .A:544 or .A:545 or .A:546 or .A:547 or .A:549 or .A:580 or .A:583 or .A:584 or .A:586 or .A:587 or .A:592 or .A:595 or .A:596 or .A:598 or .A:599 or .A:602 or .A:609 or .A:613 or .A:704 or .A:1288 or .A:1292 or .A:1401 or .A:1402 or .A:1406 or .A:1407; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN386
4.566
GLU390
4.896
LYS480
4.470
LYS532
4.599
SER544
2.792
SER545
3.621
PHE546
3.332
ASN547
3.289
PHE549
4.326
LEU580
3.987
LEU583
3.480
ARG584
3.239
PHE586
4.786
LYS587
2.569
TRP592
3.461
|
|||||
| PDB ID: 7VFW Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PT5 or .PT52 or .PT53 or :3PT5;style chemicals stick;color identity;select .A:386 or .A:480 or .A:532 or .A:544 or .A:545 or .A:546 or .A:547 or .A:549 or .A:580 or .A:583 or .A:584 or .A:587 or .A:592 or .A:595 or .A:596 or .A:598 or .A:599 or .A:602 or .A:606 or .A:609 or .A:613 or .A:704 or .A:707 or .A:1285 or .A:1288 or .A:1292 or .A:1401 or .A:1402 or .A:1406 or .A:1407; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN386
4.714
LYS480
4.451
LYS532
4.644
SER544
3.968
SER545
3.245
PHE546
3.458
ASN547
3.440
PHE549
4.625
LEU580
3.964
LEU583
3.448
ARG584
2.438
LYS587
2.562
TRP592
3.453
LEU595
3.446
ARG596
2.720
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca(V)2.2. Cell Rep. 2021 Nov 2;37(5):109931. | ||||
| REF 2 | Structure of human Ca(v)2.2 channel blocked by the painkiller ziconotide. Nature. 2021 Aug;596(7870):143-147. | ||||
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