Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38338 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) | ||||
| Synonyms | Voltage-gated calcium channel alpha subunit Cav2.2; Voltage-dependent N-type calcium channel alpha-1B subunit; N-type Ca2+ channel; Calcium channel, L type, alpha-1 polypeptide isoform 5; CACNA1B; Brain calcium channel III; BIII | ||||
| Target Type | Successful Target | ||||
| Gene Name | CACNA1B | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Hexadecane | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCCCC | ||||
| InChI | 1S/C16H34/c1-3-5-7-9-11-13-15-16-14-12-10-8-6-4-2/h3-16H2,1-2H3 | ||||
| InChIKey | DCAYPVUWAIABOU-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 11006 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7VFS Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
|
GLY165
3.799
TRP166
3.789
MET169
4.587
LEU197
4.461
LEU200
4.156
LYS214
4.178
PHE237
3.892
ILE240
3.784
PHE244
3.709
TYR245
3.285
ASN299
3.802
LEU301
3.662
PHE302
3.576
ILE304
3.761
LEU305
4.399
ALA327
3.920
ASN329
3.599
THR330
3.922
TRP331
3.514
ASN332
3.380
TRP333
3.634
LEU334
3.314
TYR335
3.969
ILE337
3.549
PRO338
3.877
ILE342
4.731
LEU348
4.344
LEU352
4.324
SER571
4.823
PHE572
4.046
LEU577
4.167
LEU580
4.457
LEU613
3.979
LEU616
4.119
PHE617
3.847
ILE620
3.970
PHE623
4.303
LEU626
3.717
LEU630
3.813
PRO650
4.059
ILE653
3.667
LEU654
3.743
PHE657
4.444
LEU660
4.489
THR661
4.054
GLN676
3.653
GLY677
4.909
VAL679
3.823
SER680
4.164
LYS681
3.659
MET683
3.474
PHE684
3.705
SER685
3.651
SER686
3.788
PHE687
4.217
TYR688
3.869
ILE690
4.368
VAL691
4.193
ASN697
4.620
LEU700
4.474
LEU701
3.674
PHE704
4.806
ALA1161
3.754
LEU1162
4.083
SER1164
3.828
ILE1165
4.481
ALA1166
4.480
ALA1169
4.710
PRO1178
4.894
ARG1179
4.322
ALA1182
4.669
LEU1183
4.716
LEU1186
4.746
LEU1218
3.671
TRP1219
3.716
LEU1222
3.888
ASN1245
4.444
LYS1248
3.313
SER1249
3.933
VAL1252
3.702
LEU1253
4.459
VAL1255
4.301
LEU1256
3.869
PRO1258
4.216
LEU1259
4.353
THR1261
3.823
LEU1265
4.152
LYS1267
3.799
PHE1272
3.859
LEU1279
3.735
LEU1286
3.830
TYR1289
4.319
MET1290
3.928
PHE1292
3.496
MET1293
3.849
PHE1296
3.591
ILE1299
4.211
LEU1303
4.527
ASN1350
3.758
LEU1352
3.917
TRP1353
3.508
LEU1355
3.981
LEU1356
3.927
PHE1359
4.167
SER1362
4.314
THR1363
3.989
MET1390
4.093
GLU1391
3.968
LEU1392
3.689
SER1393
4.661
ILE1394
4.407
PHE1395
4.549
VAL1397
3.775
VAL1398
4.210
VAL1401
4.056
PRO1404
3.974
PHE1405
3.562
VAL1408
3.602
ASN1409
3.268
PHE1411
4.503
VAL1412
3.625
VAL1486
3.687
MET1490
3.963
PHE1492
4.140
PRO1496
3.675
TYR1499
3.818
ILE1562
4.599
LEU1564
4.959
SER1565
4.253
LEU1569
3.801
PRO1600
3.665
TYR1601
3.819
CYS1603
4.213
LEU1604
4.217
ALA1607
4.024
MET1608
3.743
PHE1610
4.068
PHE1611
4.260
ILE1612
4.088
TYR1613
3.537
ILE1616
3.579
VAL1620
4.080
LEU1642
3.403
GLN1643
4.172
LEU1645
3.579
MET1646
3.763
PHE1649
4.095
SER1666
3.421
GLY1680
4.071
SER1681
3.434
ASP1682
3.270
PHE1683
3.667
TYR1685
3.852
PHE1686
3.490
TYR1687
4.721
VAL1689
3.707
SER1690
3.846
ILE1692
4.253
PHE1693
3.487
LEU1694
4.239
SER1696
3.293
PHE1697
3.709
LEU1700
3.633
|
|||||
| PDB ID: 7VFU Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
|
GLY165
3.688
TRP166
3.978
MET169
4.058
LEU197
4.742
LEU200
3.792
LYS214
3.723
PHE237
3.602
ILE240
4.304
PHE244
3.646
TYR245
3.341
ASN299
4.052
LEU301
3.598
PHE302
3.530
ILE304
3.754
LEU305
4.620
ALA327
4.251
ASN329
3.445
THR330
4.099
TRP331
3.381
ASN332
3.183
TRP333
3.737
LEU334
3.260
TYR335
3.866
ILE337
3.470
PRO338
3.793
ILE342
4.402
LEU348
4.430
LEU352
4.403
PHE572
3.958
LEU577
4.239
LEU580
4.645
LEU613
4.083
LEU616
3.716
PHE617
3.562
ILE620
3.647
PHE623
4.731
LEU626
4.161
LEU630
3.695
PRO650
3.982
ILE653
3.685
LEU654
4.022
PHE657
4.129
LEU660
4.257
THR661
4.294
GLN676
3.623
VAL679
3.896
SER680
4.187
LYS681
4.109
GLY682
4.771
MET683
3.672
PHE684
3.619
SER685
3.605
SER686
3.978
PHE687
3.723
TYR688
4.074
ILE690
4.119
VAL691
3.993
ASN697
3.787
LEU700
3.946
LEU701
4.073
PHE704
4.738
ALA1161
3.921
LEU1162
4.055
SER1164
4.216
ILE1165
4.385
ALA1166
4.495
ALA1169
4.856
PRO1178
4.412
ARG1179
4.051
ALA1182
4.577
LEU1183
4.085
LEU1186
3.649
LEU1218
3.766
TRP1219
3.632
LEU1222
4.561
ASN1245
4.148
LYS1248
3.372
SER1249
4.255
VAL1252
3.612
VAL1255
4.652
LEU1256
3.596
PRO1258
4.296
LEU1259
4.017
THR1261
4.032
LEU1265
3.893
LYS1267
4.577
LYS1269
4.560
PHE1272
4.050
LEU1279
3.618
VAL1282
4.941
LEU1286
3.957
TYR1289
4.063
MET1290
3.660
PHE1292
3.682
MET1293
3.610
PHE1296
3.652
ILE1299
3.700
LEU1303
4.795
ASN1350
3.459
LEU1352
3.655
TRP1353
3.603
LEU1355
3.966
LEU1356
4.038
PHE1359
4.015
SER1362
4.505
THR1363
3.920
MET1390
3.618
GLU1391
3.732
LEU1392
4.014
SER1393
4.285
ILE1394
4.270
PHE1395
4.502
VAL1397
3.735
VAL1398
4.199
VAL1401
4.157
PRO1404
3.645
PHE1405
3.665
VAL1408
3.886
ASN1409
3.761
PHE1411
4.250
VAL1412
3.888
VAL1486
3.722
MET1490
3.997
PHE1492
4.198
PRO1496
3.752
TYR1499
3.200
ILE1562
4.372
LEU1564
4.831
LEU1569
3.888
PRO1600
3.696
TYR1601
3.425
CYS1603
4.316
LEU1604
4.289
ALA1607
4.201
MET1608
4.192
PHE1610
4.411
PHE1611
4.530
ILE1612
3.898
TYR1613
3.579
ILE1616
3.621
VAL1620
4.357
LEU1642
3.242
GLN1643
4.796
LEU1645
3.623
MET1646
3.797
PHE1649
4.068
SER1666
3.320
GLY1680
4.702
SER1681
3.705
ASP1682
3.629
PHE1683
3.736
TYR1685
3.591
PHE1686
3.503
VAL1689
3.613
SER1690
4.227
ILE1692
4.219
PHE1693
3.509
LEU1694
3.911
SER1696
3.737
PHE1697
3.718
LEU1700
3.696
PHE1703
4.983
|
|||||
| PDB ID: 7VFV Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
|
GLY165
3.884
TRP166
3.682
MET169
4.965
ARG189
4.665
LEU197
4.231
LEU200
4.134
PHE237
3.954
ILE240
4.278
PHE244
3.736
TYR245
3.251
ASN299
4.408
LEU301
3.601
PHE302
3.477
ILE304
3.817
LEU305
4.438
ASN329
3.664
THR330
4.040
TRP331
3.576
ASN332
3.956
TRP333
3.735
LEU334
3.647
TYR335
4.048
ILE337
3.585
PRO338
3.927
ILE342
4.529
PHE572
4.153
LEU577
3.672
LEU580
4.850
LEU613
4.013
LEU616
4.049
PHE617
4.033
ILE620
4.247
PHE623
4.845
LEU626
4.012
LEU630
3.770
PRO650
4.416
ILE653
3.751
LEU654
4.036
PHE657
4.492
GLN676
3.634
VAL679
4.955
SER680
4.024
LYS681
3.967
GLY682
4.883
MET683
3.706
PHE684
3.611
SER685
3.567
SER686
4.049
PHE687
4.146
TYR688
4.101
ILE690
4.359
VAL691
4.390
ALA1161
4.131
LEU1162
4.426
SER1164
4.274
ILE1165
4.074
ALA1166
4.578
ARG1179
4.708
ALA1182
4.556
LEU1183
4.717
LEU1186
3.786
LEU1218
3.738
TRP1219
3.604
LEU1222
4.863
ASN1245
3.290
LYS1248
3.362
SER1249
4.476
VAL1252
3.960
LEU1256
3.917
PRO1258
4.120
LEU1259
4.961
THR1261
4.729
LEU1265
4.422
LYS1267
4.405
PHE1272
4.047
PHE1292
4.381
MET1293
3.681
ILE1295
4.418
PHE1296
3.543
ILE1299
4.054
LEU1303
4.802
ASN1350
4.168
LEU1352
3.549
TRP1353
3.660
LEU1355
4.088
LEU1356
4.033
PHE1359
3.972
MET1390
4.134
GLU1391
3.799
LEU1392
4.053
SER1393
4.678
ILE1394
4.601
PHE1395
4.331
VAL1397
3.882
VAL1398
4.341
VAL1401
4.307
VAL1486
4.226
MET1490
4.365
PHE1492
3.891
PRO1496
4.795
TYR1499
4.436
ILE1562
3.626
SER1565
4.728
PHE1566
3.633
LEU1569
4.094
PRO1600
3.755
TYR1601
3.834
CYS1603
4.568
LEU1604
4.215
ALA1607
4.176
MET1608
4.170
PHE1610
4.722
PHE1611
3.822
ILE1612
4.418
TYR1613
3.710
ILE1616
3.683
VAL1620
4.352
LEU1642
3.348
GLN1643
4.049
LEU1645
3.760
MET1646
3.755
PHE1649
3.643
SER1666
4.047
GLY1680
4.732
SER1681
3.591
ASP1682
3.375
PHE1683
3.505
TYR1685
4.103
PHE1686
3.528
TYR1687
4.953
VAL1689
3.596
SER1690
4.334
PHE1693
4.534
LEU1694
4.374
|
|||||
| PDB ID: 7VFW Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
NVVRKYAKRI
91 TEWPPFEYMI101 LATIIANCIV111 LALEQHLPDG121 DKTPMSERLD131 DTEPYFIGIF 141 CFEAGIKIIA151 LGFVFHKGSY161 LRNGWNVMDF171 VVVLTGILAT181 AGTDFDLRTL 191 RAVRVLRPLK201 LVSGIPSLQV211 VLKSIMKAMV221 PLLQIGLLLF231 FAILMFAIIG 241 LEFYMGKFHK251 ACFPNSTDAE261 PVGDFPCGKE271 APARLCEGDT281 ECREYWPGPN 291 FGITNFDNIL301 FAILTVFQCI311 TMEGWTDILY321 NTNDAAGNTW331 NWLYFIPLII 341 IGSFFMLNLV351 LGVLSGEFAK361 ERERVENRRA371 FLKLRRQQQI381 ERELNGYLEW 391 IFKAEEVMLA401 EEDRNSYFRR466 KEKMFRFFIR476 RMVKAQSFYW486 VVLCVVALNT 496 LCVAMVHYNQ506 PRRLTTTLYF516 AEFVFLGLFL526 TEMSLKMYGL536 GPRSYFRSSF 546 NCFDFGVIVG556 SVFEVVWAAI566 KPGSSFGISV576 LRALRLLRIF586 KVTKYWSSLR 596 NLVVSLLNSM606 KSIISLLFLL616 FLFIVVFALL626 GMQLFGGQFN636 FQDETPTTNF 646 DTFPAAILTV656 FQILTGEDWN666 AVMYHGIESQ676 GGVSKGMFSS686 FYFIVLTLFG 696 NYTLLNVFLA706 IAVDNLANAQ716 ELTKDEEEME726 EAANQKLALQ736 KAKEVAARSV 767 WEQRASQLRL777 QNLRASRRFC1143 HYIVTMRYFE1153 VVILVVIALS1163 SIALAAEDPV 1173 RTDSPRNNAL1183 KYLDYIFTGV1193 FTFEMVIKMI1203 DLGLLLHPGA1213 YFRDLWNILD 1223 FIVVSGALVA1233 FAFSGSKGKD1243 INTIKSLRVL1253 RVLRPLKTIK1263 RLPKLKAVFD 1273 CVVNSLKNVL1283 NILIVYMLFM1293 FIFAVIAVQL1303 FKGKFFYCTD1313 ESKELERDCR 1323 GQYLDYEKEE1333 VEAQPRQWKK1343 YDFHYDNVLW1353 ALLTLFTVST1363 GEGWPMVLKH 1373 SVDATYEEQG1383 PSPGYRMELS1393 IFYVVYFVVF1403 PFFFVNIFVA1413 LIIITFQEQK 1434 NERACIDFAI1444 SAPQNRQSFQ1461 YKTWTFVVSP1471 PFEYFIMAMI1481 ALNTVVLMMK 1491 FYDAPYEYEL1501 MLKCLNIVFT1511 SMFSMECVLK1521 IIAFGVLNYF1531 RDAWNVFDFV 1541 TVLGSITDIL1551 VTEIAETNNF1561 INLSFLRLFR1571 AARLIKLLRQ1581 GYTIRILLWT 1591 FVQSFKALPY1601 VCLLIAMLFF1611 IYAIIGMQVF1621 GNIALDDDTS1631 INRHNNFRTF 1641 LQALMLLFRS1651 ATGEAWHEIM1661 LSCLSNQACD1671 EQANATECGS1681 DFAYFYFVSF 1691 IFLCSFLMLN1701 LFVAVIMDNF1711 EYLTRDSSIL1721 GPHHLDEFIR1731 VWANDMFEML 1753 KHMSVHFTST1794 LMALIRTALE1804 ITKQHQCDAE1820 LRKEISVVWA1830 NLPQKTLDLL 1840 VPPHKP
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R16 or .R162 or .R163 or :3R16;style chemicals stick;color identity;select .A:165 or .A:166 or .A:169 or .A:197 or .A:200 or .A:237 or .A:240 or .A:244 or .A:245 or .A:299 or .A:301 or .A:302 or .A:304 or .A:305 or .A:329 or .A:330 or .A:331 or .A:332 or .A:333 or .A:334 or .A:335 or .A:337 or .A:338 or .A:342 or .A:572 or .A:577 or .A:580 or .A:613 or .A:616 or .A:617 or .A:620 or .A:623 or .A:626 or .A:630 or .A:650 or .A:653 or .A:654 or .A:657 or .A:676 or .A:679 or .A:680 or .A:681 or .A:682 or .A:683 or .A:684 or .A:685 or .A:686 or .A:687 or .A:688 or .A:690 or .A:691 or .A:1161 or .A:1162 or .A:1164 or .A:1165 or .A:1166 or .A:1179 or .A:1182 or .A:1183 or .A:1186 or .A:1218 or .A:1219 or .A:1245 or .A:1248 or .A:1252 or .A:1256 or .A:1258 or .A:1261 or .A:1265 or .A:1267 or .A:1272 or .A:1292 or .A:1293 or .A:1295 or .A:1296 or .A:1299 or .A:1303 or .A:1350 or .A:1352 or .A:1353 or .A:1355 or .A:1356 or .A:1359 or .A:1390 or .A:1391 or .A:1392 or .A:1393 or .A:1394 or .A:1395 or .A:1397 or .A:1398 or .A:1401 or .A:1486 or .A:1490 or .A:1492 or .A:1496 or .A:1499 or .A:1562 or .A:1565 or .A:1566 or .A:1569 or .A:1600 or .A:1601 or .A:1603 or .A:1604 or .A:1607 or .A:1608 or .A:1610 or .A:1611 or .A:1612 or .A:1613 or .A:1616 or .A:1620 or .A:1642 or .A:1643 or .A:1645 or .A:1646 or .A:1649 or .A:1666 or .A:1680 or .A:1681 or .A:1682 or .A:1683 or .A:1685 or .A:1686 or .A:1689 or .A:1693 or .A:1694; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY165
3.779
TRP166
3.761
MET169
4.368
LEU197
4.373
LEU200
4.354
PHE237
3.954
ILE240
4.278
PHE244
3.736
TYR245
3.251
ASN299
4.408
LEU301
3.601
PHE302
3.477
ILE304
3.817
LEU305
4.438
ASN329
3.664
THR330
4.040
TRP331
3.576
ASN332
3.956
TRP333
3.735
LEU334
3.647
TYR335
4.048
ILE337
3.585
PRO338
3.927
ILE342
4.529
PHE572
4.153
LEU577
3.672
LEU580
4.850
LEU613
4.013
LEU616
4.049
PHE617
4.033
ILE620
4.247
PHE623
4.845
LEU626
4.012
LEU630
3.770
PRO650
4.416
ILE653
3.751
LEU654
4.036
PHE657
4.492
GLN676
3.634
VAL679
4.955
SER680
4.024
LYS681
3.967
GLY682
4.883
MET683
3.706
PHE684
3.611
SER685
3.567
SER686
4.049
PHE687
4.146
TYR688
4.101
ILE690
4.359
VAL691
4.390
ALA1161
4.131
LEU1162
4.426
SER1164
4.274
ILE1165
4.074
ALA1166
4.578
ARG1179
4.708
ALA1182
4.556
LEU1183
4.717
LEU1186
3.786
LEU1218
3.966
TRP1219
4.122
ASN1245
3.486
LYS1248
3.741
VAL1252
3.909
LEU1256
4.398
PRO1258
4.120
THR1261
4.729
LEU1265
4.422
LYS1267
4.405
PHE1272
3.880
PHE1292
4.381
MET1293
4.077
ILE1295
4.418
PHE1296
3.543
ILE1299
4.054
LEU1303
4.802
ASN1350
4.262
LEU1352
3.581
TRP1353
3.733
LEU1355
3.842
LEU1356
4.067
PHE1359
3.696
MET1390
4.134
GLU1391
3.799
LEU1392
4.053
SER1393
4.678
ILE1394
4.601
PHE1395
4.331
VAL1397
3.882
VAL1398
4.341
VAL1401
4.307
VAL1486
4.226
MET1490
4.365
PHE1492
3.891
PRO1496
4.795
TYR1499
4.436
ILE1562
3.626
SER1565
4.728
PHE1566
3.633
LEU1569
4.094
PRO1600
3.755
TYR1601
3.834
CYS1603
4.568
LEU1604
4.215
ALA1607
4.176
MET1608
4.170
PHE1610
4.722
PHE1611
3.822
ILE1612
4.591
TYR1613
3.665
ILE1616
3.868
VAL1620
4.309
LEU1642
3.348
GLN1643
4.049
LEU1645
3.760
MET1646
3.755
PHE1649
3.643
SER1666
4.047
GLY1680
4.732
SER1681
3.591
ASP1682
3.947
PHE1683
3.851
TYR1685
3.743
PHE1686
3.580
VAL1689
4.247
PHE1693
3.793
LEU1694
4.180
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca(V)2.2. Cell Rep. 2021 Nov 2;37(5):109931. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.