Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48069 | Target Info | |||
| Target Name | Insulin-like growth factor I receptor (IGF1R) | ||||
| Synonyms | Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221 | ||||
| Target Type | Successful Target | ||||
| Gene Name | IGF1R | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | D-malate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)O)C(=O)O | ||||
| InChI | 1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1 | ||||
| InChIKey | BJEPYKJPYRNKOW-UWTATZPHSA-N | ||||
| PubChem Compound ID | 92824 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5U8R Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
EICGPGIDIR
10 NDYQQLKRLE20 NCTVIEGYLH30 ILLISKARSY43 RFPKLTVITE53 YLLLFRVAGL 63 ESLGDLFPNL73 TVIRGWKLFY83 NYALVIFEMT93 NLKDIGLYNL103 RNITRGAIRI 113 EKNADLCYLS123 TVDWSLILDA133 VSNNYIVGNK143 PPKECGDLCP153 GCEKTTINNE 170 YNYRCWTTNR180 CQKMCPSTCG190 KRACTENNEC200 CHPECLGSCS210 APDNDTACVA 220 CRHYYYAGVC230 VPACPPNTYR240 FEGWRCVDRD250 FCANILSAES260 SDSEGFVIHD 270 GECMQECPSG280 FIRNGSQSMY290 CIPCEGPCPK300 VCEEEKKTKT310 IDSVTSAQML 320 QGCTIFKGNL330 LINIRRGNNI340 ASELENFMGL350 IEVVTGYVKI360 RHSHALVSLS 370 FLKNLRLILG380 EEQLEGNYSF390 YVLDNQNLQQ400 LWDWDHRNLT410 IKAGKMYFAF 420 NPKLCVSEIY430 RMEEVTGTKG440 RQSKGDINTR450 NNGERASCES460 DVLHFTSTTT 470 SKNRIIITWH480 RYRPPDYRDL490 ISFTVYYKEA500 PFKNVTEYNS518 WNMVDVDLPP 528 NKDVEPGILL538 HGLKPWTQYA548 VYVKAVTLTM558 VENDHIRGAK568 SEILYIRTNA 578 SVPSIPLDVL588 SASNSSSQLI598 VKWNPPSLPN608 GNLSYYIVRW618 QRQPQDGYLY 628 RHNYCSKDKI638 PIRKEKEEAE687 YRKVFENFLH697 NSIFVPREYP746 FFESRVDNKE 756 RTVISNLRPF766 TLYRIDIHSC776 NHEAEKLGCS786 ASNFVFARTM796 PAEGADDIPG 806 PVTWEPRPEN816 SIFLKWPEPE826 NPNGLILMYE836 IKYGSQVEDQ846 RECVSRQEYR 856 KYGGAKLNRL866 NPGNYTARIQ876 ATSLSGNGSW886 TDPVFFYVQA896 K |
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| PDB ID: 5U8Q Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I | ||||||
| Method | X-ray diffraction | Resolution | 3.27 Å | Mutation | No | [1] |
| PDB Sequence |
EICGPGIDIR
10 NDYQQLKRLE20 NCTVIEGYLH30 ILLISRSYRF45 PKLTVITEYL55 LLFRVAGLES 65 LGDLFPNLTV75 IRGWKLFYNY85 ALVIFEMTNL95 KDIGLYNLRN105 ITRGAIRIEK 115 NADLCYLSTV125 DWSLILDAVS135 NNYIVGNKPP145 KECGDLCPCE163 KTTINNEYNY 173 RCWTTNRCQK183 MCPSTCACTE196 NNECCHPECL206 GSCSAPDNDT216 ACVACRHYYY 226 AGVCVPACPP236 NTYRFEGWRC246 VDRDFCANIL256 SAESSDSEGF266 VIHDGECMQE 276 CPSGFIRNGS286 QSMYCIPCEG296 PCPKVCEEEK306 KTKTIDSVTS316 AQMLQGCTIF 326 KGNLLINIRR336 GNNIASELEN346 FMGLIEVVTG356 YVKIRHSHAL366 VSLSFLKNLR 376 LILGEEQLEG386 NYSFYVLDNQ396 NLQQLWDWDH406 RNLTIKAGKM416 YFAFNPKLCV 426 SEIYRMEEVT436 GTKGRQSKGD446 INTRNNGERA456 SCESDVLHFT466 STTTSKNRII 476 ITWHRYRPPD486 YRDLISFTVY496 YKEAPFKNVT506 EYDGQDACGS516 NSWNMVDVDL 526 PPNKDVEPGI536 LLHGLKPWTQ546 YAVYVKAVTL556 TMVENDHIRG566 AKSEILYIRT 576 NASVPSIPLD586 VLSASNSSSQ596 LIVKWNPPSL606 PNGNLSYYIV616 RWQRQPQDGY 626 LYRHNYCSKD636 KIPIRKYARK690 VFENFLHNSI700 FVPRPYPFFE749 SRVDNKERTV 759 ISNLRPFTLY769 RIDIHSCNHE779 AEKLGCSASN789 FVFARTMPAE799 GADDIPGPVT 809 WEPRPENSIF819 LKWPEPENPN829 GLILMYEIKY839 GSQVEDQREC849 VSRQEYRKYG 859 GAKLNRLNPG869 NYTARIQATS879 LSGNGSWTDP889 VFFYVQAKTG899 Y |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | How ligand binds to the type 1 insulin-like growth factor receptor. Nat Commun. 2018 Feb 26;9(1):821. | ||||
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