Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48069 | Target Info | |||
| Target Name | Insulin-like growth factor I receptor (IGF1R) | ||||
| Synonyms | Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221 | ||||
| Target Type | Successful Target | ||||
| Gene Name | IGF1R | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphonotyrosine | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1 | ||||
| InChIKey | DCWXELXMIBXGTH-QMMMGPOBSA-N | ||||
| PubChem Compound ID | 30819 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2ZM3 Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
SFSAADVYVP
989 DEWEVAREKI999 TMSRELGQGS1009 FGMVYEGVAK1019 GVVKDEPETR1029 VAIKTVNEAA 1039 SMRERIEFLN1049 EASVMKEFNC1059 HHVVRLLGVV1069 SQGQPTLVIM1079 ELMTRGDLKS 1089 YLRSLRPENP1102 VLAPPSLSKM1112 IQMAGEIADG1122 MAYLNANKFV1132 HRDLAARNCM 1142 VAEDFTVKIG1152 DFGMTRDIET1163 DRKGGKGLLP1175 VRWMSPESLK1185 DGVFTTYSDV 1195 WSFGVVLWEI1205 ATLAEQPYQG1215 LSNEQVLRFV1225 MEGGLLDKPD1235 NCPDMLFELM 1245 RMCWQYNPKM1255 RPSFLEIISS1265 IKEEMEPGFR1275 EVSFYYSEEN1285 |
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| PDB ID: 3F5P Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
SFSAADVYVP
989 DEWEVAREKI999 TMSRELGQGS1009 FGMVYEGVAK1019 GVVKDEPETR1029 VAIKTVNEAA 1039 SMRERIEFLN1049 EASVMKEFNC1059 HHVVRLLGVV1069 SQGQPTLVIM1079 ELMTRGDLKS 1089 YLRSLRPEML1104 APPSLSKMIQ1114 MAGEIADGMA1124 YLNANKFVHR1134 DLAARNCMVA 1144 EDFTVKIGDF1154 GMTRDIETDR1167 KGGKGLLPVR1177 WMSPESLKDG1187 VFTTYSDVWS 1197 FGVVLWEIAT1207 LAEQPYQGLS1217 NEQVLRFVME1227 GGLLDKPDNC1237 PDMLFELMRM 1247 CWQYNPKMRP1257 SFLEIISSIK1267 EEMEPGFREV1277 SFYYSEENK
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| PDB ID: 1K3A Structure of the Insulin-like Growth Factor 1 Receptor Kinase | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [3] |
| PDB Sequence |
VPDEWEVARE
967 KITMSRELGQ977 GSFGMVYEGV987 AKGVVKDEPE997 TRVAIKTVNE1007 AASMRERIEF 1017 LNEASVMKEF1027 NCHHVVRLLG1037 VVSQGQPTLV1047 IMELMTRGDL1057 KSYLRSLRPE 1067 MPSLSKMIQM1085 AGEIADGMAY1095 LNANKFVHRD1105 LAARNCMVAE1115 DFTVKIGDFG 1125 MTRDIETDRK1138 GGKGLLPVRW1148 MSPESLKDGV1158 FTTYSDVWSF1168 GVVLWEIATL 1178 AEQPYQGLSN1188 EQVLRFVMEG1198 GLLDKPDNCP1208 DMLLELMRMC1218 WQYNPKMRPS 1228 FLEIISSIKE1238 EMEPGFREVS1248 FYYSEENK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. | ||||
| REF 2 | Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett. 2009 Jan 1;19(1):62-6. | ||||
| REF 3 | Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol. 2001 Dec;8(12):1058-63. | ||||
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